A family of proteins that inhibit signalling through tyrosine kinase receptors

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1994 • 455 citations

A Novel Membrane Glycoprotein, SHPS-1, That Binds the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-2 in Response to Mitogens and Cell Adhesion

1996 • 443 citations

Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.

1990 • 401 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development

1995 • 330 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1995 • 263 citations

Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression

1996 • 247 citations

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.

1994 • 240 citations

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

1994 • 214 citations

Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling

1996 • 210 citations

Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

1986 • 203 citations

Protein tyrosine phosphatases take off

1995 • 174 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

1994 • 172 citations

Protein tyrosine phosphatases in signaling

1996 • 170 citations

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.

1992 • 129 citations

Altered Expression of Protein-tyrosine Phosphatase 2C in 293 Cells Affects Protein Tyrosine Phosphorylation and Mitogen-activated Protein Kinase Activation

1995 • 83 citations

Positive Effect of Overexpressed Protein-tyrosine Phosphatase PTP1C on Mitogen-activated Signaling in 293 Cells

1996 • 69 citations

The paradoxical regulation of protein phosphorylation in insulin action

1994 • 55 citations

Identification of the Major SHPTP2-binding Protein That Is Tyrosine-phosphorylated in Response to Insulin

1995 • 48 citations

Roles of protein-tyrosine phosphatases in growth factor signalling

1996 • 47 citations

Protein-tyrosine Phosphatase 1D Modulates Its Own State of Tyrosine Phosphorylation

1995 • 47 citations

Transforming potentials of epidermal growth factor and nerve growth factor receptors inversely correlate with their phospholipase C gamma affinity and signal activation.

1996 • 43 citations

Epidermal Growth Factor-induced Association of the SHPTP2 Protein Tyrosine Phosphatase with a 115-kDa Phosphotyrosine Protein

1995 • 32 citations

Expression of a Catalytically Inert SYP Blocks Activation of Map Kinase Pathway Downstream of P21ras

1995 • 23 citations