Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor–induced proliferation but not differentiation of immature thymocytes

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Negative Regulation of Cytokine Signaling Pathways

2000 • 607 citations

A monoclonal antibody discriminating between subsets of T and B cells.

1981 • 565 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

Expression and function of the interleukin 7 receptor in murine lymphocytes.

1993 • 496 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1

1998 • 433 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

1997 • 338 citations

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1998 • 290 citations

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1996 • 280 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

Socs1 binds to multiple signalling proteins and suppresses Steel factor-dependent proliferation

1999 • 205 citations

Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo

1995 • 201 citations

Pleiotropic changes controlled by the pre-T-cell receptor

1999 • 199 citations

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

1997 • 195 citations

Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor α-induced cell death in fibroblasts

2000 • 186 citations

The Trophic Action of IL-7 on Pro-T Cells: Inhibition of Apoptosis of Pro-T1, -T2, and -T3 Cells Correlates with Bcl-2 and Bax Levels and Is Independent of Fas and p53 Pathways

1998 • 186 citations

In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development

1998 • 128 citations

Negative regulation of cytokine signaling: STAT-induced STAT inhibitor

1999 • 128 citations

Pre-TCR Signaling and Inactivation of p53 Induces Crucial Cell Survival Pathways in Pre-T Cells

1999 • 122 citations

A GFP reporter system to assess gene transfer and expression in human hematopoietic progenitor cells

1997 • 119 citations

The role of cytokine receptor signaling in lymphocyte development

1999 • 118 citations

Cytokine-Induced Src Homology 2 Protein (Cis) Promotes T Cell Receptor–Mediated Proliferation and Prolongs Survival of Activated T Cells

2000 • 112 citations

Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR

1999 • 110 citations

Role of Different T Cell Receptors in the Development of Pre–T Cells

1997 • 108 citations

The Common Cytokine Receptor γ Chain and the Pre-T Cell Receptor Provide Independent but Critically Overlapping Signals in Early α/β T Cell Development

1999 • 88 citations

Defective Thymocyte Development and Perturbed Homeostasis of T cells in STAT-Induced STAT Inhibitor-1/Suppressors of Cytokine Signaling-1 Transgenic Mice

2000 • 84 citations

Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1

1999 • 74 citations

Regulation of T cell receptor (TCR)‐β locus allelic exclusion and initiation of TCR‐α locus rearrangement in immature thymocytes by signaling through the CD3 complex

1995 • 73 citations

Lineage commitment and differentiation of T and natural killer lymphocytes in the fetal mouse

1998 • 54 citations

Expression of the mouse interleukin‐2 receptor γ chain in various cell populations of the thymus and spleen

1994 • 54 citations

Development of T cell receptor αβ‐bearing T cells in the submersion organ culture of murine fetal thymus at high oxygen concentration

1993 • 52 citations

Extracellular Signal–Regulated Kinase (Erk) Activation by the Pre-T Cell Receptor in Developing Thymocytes in Vivo

1999 • 46 citations

Retroviral Vectors for Production of Interleukin‐12 in the Bone Marrow to Induce a Graft‐Versus‐Leukemia Effecta

1996 • 43 citations

Safe and efficient ecotropic and amphotropic packaging lines for use in gene transfer experiments.

1988 • 30 citations

Early Intrathymic Precursor Cells Acquire a CD4low Phenotype

1998 • 28 citations

Do T cells care about the mitogen‐activated protein kinase signalling pathways?

2000 • 28 citations

An Improved Retroviral Gene Transfer Technique Demonstrates Inhibition of CD4−CD8− Thymocyte Development by Kinase-Inactive ZAP-70

1998 • 25 citations

The connecting peptide domain of pTα dictates weak association of the pre-T cell receptor with the TCR ζ subunit

1999 • 22 citations

Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development.

1999 • 22 citations

Disruption of Cytokine Signaling in Lymphoid Development: Unique Contributions of the Common Cytokine Gamma Chain and the Jak3 Kinase

1996 • 14 citations