Invariant chain prevents the HLA-DR-restricted presentation of a cytosolic peptide.

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

1985 • 1,303 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae.

1982 • 617 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Antibodies to the Golgi complex and the rough endoplasmic reticulum.

1982 • 418 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens

1982 • 308 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

HLA class II-restricted presentation of cytoplasmic measles virus antigens to cytotoxic T cells

1989 • 201 citations

Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes.

1992 • 189 citations

Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens.

1990 • 149 citations

HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells.

1992 • 148 citations

Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers.

1993 • 145 citations

Two forms of the la antigen-associated invariant chain result from alternative initiations at two in-phase AUGs

1986 • 124 citations

Efficient cDNA expression vectors for stable and transient expression of HLA-DR in transfected fibroblast and lymphoid cells

1991 • 124 citations

A human Ia cytoplasmic determinant located on multiple forms of invariant chain (gamma, gamma 2, gamma 3).

1984 • 119 citations

Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.

1994 • 104 citations

CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon gene.

1988 • 94 citations

Mutations in the alpha 2 helix of HLA-A2 affect presentation but do not inhibit binding of influenza virus matrix peptide.

1988 • 83 citations

Antigen presentation of hen egg‐white lysozyme but not of ribonuclease A is augmented by the major histocompatibility complex class II‐associated invariant chain

1991 • 74 citations

Early events in the assembly of major histocompatibility complex class II heterotrimers from their free subunits

1994 • 28 citations

Major histocompatibility complex class II‐restricted presentation of secreted and endoplasmic reticulum resident antigens requires the invariant chains and is sensitive to lysosomotropic agents

1993 • 24 citations