Modulating the immune response with dendritic cells and their growth factors

Dendritic cells and the control of immunity

1998 • 14,345 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

Immunobiology of Dendritic Cells

2000 • 6,653 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1973 • 2,286 citations

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

1999 • 2,255 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1999 • 1,754 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Induction of tolerance by IL-10-treated dendritic cells.

1997 • 1,263 citations

The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand

1997 • 1,224 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1974 • 1,041 citations

Distinct dendritic cell subsets differentially regulate the class of immune responseinvivo

1999 • 1,013 citations

CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo

1999 • 998 citations

CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.

1996 • 962 citations

T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal

1999 • 957 citations

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

1997 • 937 citations

Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity

2000 • 867 citations

Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking

1998 • 832 citations

CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen

2000 • 812 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities

1998 • 722 citations

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

1995 • 687 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells

1999 • 656 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells

2000 • 560 citations

Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes.

1997 • 524 citations

Dendritic Cells Discriminate between Yeasts and Hyphae of the Fungus Candida albicans

2000 • 498 citations

Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

1998 • 480 citations

Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice.

1997 • 455 citations

The Cytokine Profile Expressed by Human Dendritic Cells Is Dependent on Cell Subtype and Mode of Activation

1998 • 436 citations

Flt3-Ligand and Granulocyte Colony-Stimulating Factor Mobilize Distinct Human Dendritic Cell Subsets In Vivo

2000 • 419 citations

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

1996 • 405 citations

Dendritic Cells as the Terminal Stage of Monocyte Differentiation

1998 • 405 citations

In vivo generation of human dendritic cell subsets by Flt3 ligand

2000 • 397 citations

Prostaglandin E2 Induces the Final Maturation of IL-12-Deficient CD1a+CD83+ Dendritic Cells: The Levels of IL-12 Are Determined During the Final Dendritic Cell Maturation and Are Resistant to Further Modulation

1998 • 379 citations

Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch.

1996 • 360 citations

Interleukin 12–dependent Interferon γ Production by CD8α+Lymphoid Dendritic Cells

1999 • 340 citations

A CD1a+/CD11c+ Subset of Human Blood Dendritic Cells Is a Direct Precursor of Langerhans Cells

1999 • 334 citations

Expanding Dendritic Cells In Vivo Enhances the Induction of Oral Tolerance

1998 • 327 citations

Dendritic cells capable of stimulating T cells in germinal centres

1996 • 309 citations

Dendritic Cells Enhance Growth and Differentiation of CD40-activated B Lymphocytes

1997 • 301 citations

Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.

1997 • 263 citations

Heterogeneity of Mouse Spleen Dendritic Cells: In Vivo Phagocytic Activity, Expression of Macrophage Markers, and Subpopulation Turnover

1998 • 261 citations

Definition of Dendritic Cell Subpopulations Present in the Spleen, Peyer’s Patches, Lymph Nodes, and Skin of the Mouse

1999 • 244 citations

Survival, Maturation, and Function of CD11c− and CD11c+ Peripheral Blood Dendritic Cells Are Differentially Regulated by Cytokines

1999 • 242 citations

A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.

1996 • 238 citations

Human Monocyte–Derived Dendritic Cells Induce Naive T Cell Differentiation into T Helper Cell Type 2 (Th2) or Th1/Th2 Effectors

2000 • 222 citations

Polyethylene Glycol-Modified GM-CSF Expands CD11bhighCD11chigh But Not CD11blowCD11chigh Murine Dendritic Cells In Vivo: A Comparative Analysis with Flt3 Ligand

2000 • 209 citations

FLT3 Ligand Induces the Generation of Functionally Active Dendritic Cells in Mice

1997 • 193 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein

1990 • 164 citations

Anti-inflammatory effects of granulocyte colony-stimulating factor

1998 • 164 citations

Antigen-pulsed CD8α+ Dendritic Cells Generate an Immune Response after Subcutaneous Injection without Homing to the Draining Lymph Node

1999 • 161 citations

Expression of pT mRNA in a Committed Dendritic Cell Precursor in the Human Thymus

1999 • 153 citations

Identification of CD68+lin− Peripheral Blood Cells with Dendritic Precursor Characteristics

1998 • 141 citations

Three populations of mouse lymph node dendritic cells with different origins and dynamics

1997 • 133 citations

On the mechanisms by which transforming growth factor‐β2 alters antigen‐presenting abilities of macrophages on T cell activation

1997 • 121 citations

The linkage between T‐cell and dendritic cell development in the mouse thymus

1998 • 118 citations

Prevention of Peripheral Tolerance by a Dendritic Cell Growth Factor: Flt3 Ligand as an Adjuvant

1998 • 110 citations

Three Populations of Mouse Lymph Node Dendritic Cells with Different Origins and Dynamics

1998 • 99 citations

CTL priming by CD8+ and CD8– dendritic cellsin vivo

1999 • 76 citations

Identification of a Committed T Cell Precursor Population in Adult Human Peripheral Blood

1997 • 72 citations

The lipid A moiety of Porphyromonas gingivalis lipopolysaccharide specifically mediates the activation of C3H/HeJ mice.

1997 • 60 citations

The Activated Type 1–Polarized Cd8+ T Cell Population Isolated from an Effector Site Contains Cells with Flexible Cytokine Profiles

1999 • 33 citations