Functional Interference between the Ubiquitous and Constitutive Octamer Transcription Factor 1 (OTF-1) and the Glucocorticoid Receptor by Direct Protein-Protein Interaction Involving the Homeo Subdomain of OTF-1

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Expression of a large family of POU-domain regulatory genes in mammalian brain development

1989 • 828 citations

Reduced levels of hsp90 compromise steroid receptor action in vivo

1990 • 794 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

1988 • 670 citations

Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain

1990 • 609 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

Retinoic acid is a negative regulator of AP-1-responsive genes.

1991 • 542 citations

The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

1988 • 522 citations

Many Transcription Factors Interact Synergistically with Steroid Receptors

1988 • 517 citations

Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene

1987 • 516 citations

A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells

1988 • 494 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.

1988 • 429 citations

Functional antagonism between c-Jun and MyoD proteins: A direct physical association

1992 • 424 citations

A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein

1988 • 399 citations

Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitro

1987 • 386 citations

A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins.

1988 • 381 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

Octamania: The POU factors in murine development

1991 • 373 citations

Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB.

1990 • 290 citations

OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts

1987 • 255 citations

Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.

1992 • 250 citations

The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein.

1989 • 245 citations

A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain

1988 • 234 citations

Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element.

1988 • 234 citations

Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator protein.

1990 • 227 citations

Ubiquitous transcription factor OTF-1 mediates induction of the MMTV promoter through synergistic interaction with hormone receptors

1991 • 224 citations

A common octamer motif binding protein is involved in the transcription of U6 snRNA by RNA polymerase III and U2 snRNA by RNA polymerase II

1987 • 224 citations

Down-regulation and Phosphorylation of Glucocorticoid Receptors in Cultured Cells

1989 • 223 citations

I-POU: a POU-domain protein that inhibits neuron-specific gene activation

1991 • 217 citations

Transcriptional repression in eukaryotes

1990 • 210 citations

The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

1990 • 204 citations

Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.

1991 • 195 citations

Transcription Factor OTF-1 Is Functionally Identical to the DNA Replication Factor NF-III

1988 • 194 citations

Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase.

1979 • 191 citations

Monoclonal antibodies against the rat liver glucocorticoid receptor.

1984 • 188 citations

Characterization of the purified activated glucocorticoid receptor from rat liver cytosol.

1984 • 186 citations

Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state

1988 • 186 citations

Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper

1991 • 177 citations

Purification and analysis of RNA polymerase II transcription factors by using wheat germ agglutinin affinity chromatography.

1989 • 175 citations

The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: a potential mechanism for negative regulation.

1991 • 163 citations

Direct combinatorial interaction between a herpes simplex virus regulatory protein and a cellular octamer-binding factor mediates specific induction of virus immediate-early gene expression.

1988 • 157 citations

Novel Pathway for Thyroid Hormone Receptor Action through Interaction with jun and fos Oncogene Activities

1991 • 154 citations

A novel mechanism of action for v-ErbA: Abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors

1991 • 154 citations

Differential Phosphorylation of the Transcription Factor Oct1 During the Cell Cycle

1991 • 145 citations

Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP ⁴⁰

1991 • 144 citations

Unregulated expression of c-Jun or c-Fos proteins but not Jun D inhibits oestrogen receptor activity in human breast cancer derived cells.

1991 • 134 citations

The Oct-2 protein binds cooperatively to adjacent octamer sites.

1989 • 132 citations

The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain.

1991 • 128 citations

Functional cooperativity between protein molecules bound at two distinct sequence elements of the immunoglobulin heavy-chain promoter

1989 • 128 citations

Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters.

1990 • 117 citations

A Family of POU-Domain and Pit-1 Tissue-Specific Transcription Factors in Pituitary and Neuroendocrine Development

1990 • 115 citations

Purified octamer binding transcription factors stimulate RNA polymerase III-mediated transcription of the 7SK RNA gene

1989 • 108 citations

Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper

1991 • 106 citations

High level expression of functional full length and truncated glucocorticoid receptor in Chinese hamster ovary cells. Demonstration of ligand-induced down-regulation of expressed receptor mRNA and protein

1991 • 99 citations

Segments of the POU domain influence one another's DNA-binding specificity.

1992 • 99 citations

Octamer Transcription Factors 1 and 2 Each Bind to Two Different Functional Elements in the Immunoglobulin Heavy-Chain Promoter

1989 • 90 citations

Histone H1 subtype-specific consensus elements mediate cell cycle-regulated transcription in vitro.

1989 • 88 citations

The Oct-1 POU domain mediates interactions between Oct-1 and other POU proteins.

1992 • 84 citations

Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration

1991 • 81 citations

Interference and synergism of glucocorticoid receptor and octamer factors.

1991 • 77 citations

High Level Expression in Escherichia coli of the DNA-binding Domain of the Glucocorticoid Receptor in a Functional Form Utilizing Domainspecific Cleavage of a Fusion Protein

1989 • 67 citations

Highly inducible expression from vectors containing multiple GRE's in CHO cells overexpressing the glucocorticoid receptor

1989 • 66 citations

Retinoic acid-induced down-regulation of the interleukin-2 promoter via cis-regulatory sequences containing an octamer motif.

1991 • 63 citations

Role of the ligand in intracellular receptor function: receptor affinity determines activation in vitro of the latent dioxin receptor to a DNA-binding form.

1991 • 51 citations