Caspases involved in ER stress-mediated cell death

Caspases: Enemies Within

1998 • 6,923 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Organelle-specific initiation of cell death pathways

2001 • 1,454 citations

Proteases to die for

1998 • 1,241 citations

Cross-Talk between Two Cysteine Protease Families

2000 • 1,158 citations

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

2003 • 1,045 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis

2002 • 875 citations

Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress

2001 • 832 citations

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death

2004 • 813 citations

Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors

2003 • 682 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

2002 • 560 citations

JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis

2003 • 512 citations

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

2003 • 509 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2002 • 480 citations

Alice in caspase land. A phylogenetic analysis of caspases from worm to man

2002 • 376 citations

Human caspase 12 has acquired deleterious mutations

2002 • 348 citations

Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes

2002 • 342 citations

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

1995 • 313 citations

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

2000 • 304 citations

Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases

1995 • 281 citations

Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases

1995 • 262 citations

Characterization of seven murine caspase family members

1997 • 207 citations

ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation

2003 • 190 citations

A novel protein, RTN-xS, interacts with both Bcl-xL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity

2000 • 168 citations

Export of Cellubrevin from the Endoplasmic Reticulum Is Controlled by BAP31

1997 • 153 citations

Regulation of the expression and processing of caspase-12

2003 • 132 citations

The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum

2002 • 123 citations

Caspase-Resistant BAP31 Inhibits Fas-Mediated Apoptotic Membrane Fragmentation and Release of Cytochrome cfrom Mitochondria

2000 • 117 citations

Caspase-12 processing and fragment translocation into nuclei of tunicamycin-treated cells

2002 • 71 citations