HES and HERP families: Multiple effectors of the notch signaling pathway

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

1996 • 1,951 citations

Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms

2000 • 1,761 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

Notch signalling controls pancreatic cell differentiation

1999 • 1,147 citations

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

1997 • 1,121 citations

Notch signaling is essential for vascular morphogenesis in mice

2000 • 1,042 citations

Notch Signaling: From the Outside In

2000 • 958 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Avian hairy Gene Expression Identifies a Molecular Clock Linked to Vertebrate Segmentation and Somitogenesis

1997 • 954 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

Notch signaling is required for arterial-venous differentiation during embryonic vascular development

2001 • 899 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

1999 • 817 citations

Embryonic Lethality and Vascular Defects in Mice Lacking the Notch Ligand Jagged1

1999 • 756 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

1997 • 721 citations

Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain

2000 • 716 citations

Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells

2000 • 715 citations

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

1995 • 702 citations

Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.

1992 • 667 citations

A natural classification of the basic helix–loop–helix class of transcription factors

1997 • 631 citations

Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3

2000 • 625 citations

Maintenance of somite borders in mice requires the Delta homologue Dll1

1997 • 623 citations

Jagged: A mammalian ligand that activates notch1

1995 • 617 citations

Conservation of the Notch signalling pathway in mammalian neurogenesis

1997 • 617 citations

The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3

2001 • 593 citations

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

1998 • 587 citations

Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex

1997 • 565 citations

Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins

1994 • 560 citations

The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

2000 • 556 citations

Gridlock signalling pathway fashions the first embryonic artery

2001 • 552 citations

LIN-12/Notch signaling: lessons from worms and flies

1998 • 545 citations

Dll4, a novel Notch ligand expressed in arterial endothelium

2000 • 522 citations

rax, Hes1, and notch1 Promote the Formation of Müller Glia by Postnatal Retinal Progenitor Cells

2000 • 519 citations

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

1996 • 497 citations

Structure and function of helix-loop-helix proteins

1994 • 496 citations

The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD

1994 • 483 citations

A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness

2000 • 482 citations

Disruption of the mouse RBP-Jк gene results in early embryonic death

1995 • 478 citations

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)

1995 • 476 citations

Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects

1999 • 462 citations

Inhibition of PPARγ2 Gene Expression by the HIF-1-Regulated Gene DEC1/Stra13

2002 • 454 citations

A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development

1999 • 441 citations

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels

2001 • 433 citations

gridlock , an HLH Gene Required for Assembly of the Aorta in Zebrafish

2000 • 427 citations

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

1993 • 421 citations

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

1998 • 409 citations

Defects in somite formation in lunatic fringe-deficient mice

1998 • 405 citations

Induction of Cyclin D1 Transcription and CDK2 Activity by Notch^ic: Implication for Cell Cycle Disruption in Transformation by Notch^ic

2001 • 403 citations

lunatic fringe is an essential mediator of somite segmentation and patterning

1998 • 395 citations

Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning

2001 • 373 citations

Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway

1996 • 372 citations

The histone deacetylase-3 complex contains nuclear receptor corepressors

2000 • 367 citations

Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system

1997 • 364 citations

Expression Patterns ofJagged, Delta1, Notch1, Notch2,andNotch3Genes Identify Ligand–Receptor Pairs That May Function in Neural Development

1996 • 360 citations

Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation

2001 • 356 citations

Alterations in Notch signaling in neoplastic lesions of the human cervix.

1995 • 355 citations

Dynamic expression and essential functions of Hes7 in somite segmentation

2001 • 353 citations

The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain

1996 • 344 citations

Notch signalling is required for cyclic expression of the hairy-like geneHES1in the presomitic mesoderm

2000 • 336 citations

Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation

1998 • 328 citations

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1

2000 • 323 citations

Systemic vascular smooth muscle cell impairment in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

1995 • 313 citations

Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts

1999 • 304 citations

Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system.

1992 • 301 citations

Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements.

1994 • 301 citations

An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells

1994 • 298 citations

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium

2001 • 290 citations

Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives

1997 • 289 citations

The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis

1997 • 287 citations

The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries

1998 • 280 citations

Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality

1999 • 277 citations

HRT1, HRT2, and HRT3: A New Subclass of bHLH Transcription Factors Marking Specific Cardiac, Somitic, and Pharyngeal Arch Segments

1999 • 276 citations

NF-κB2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jκ

1998 • 272 citations

Glial cell fate specification modulated by the bHLH gene Hes5in mouse retina

2000 • 269 citations

Conservation of the Drosophila lateral inhibition pathway in human lung cancer: A hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression

1997 • 269 citations

Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis

1999 • 268 citations

Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway

1998 • 261 citations

The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation

2000 • 259 citations

Arbiter of differentiation and death: Notch signaling meets apoptosis

1999 • 255 citations

The lunatic Fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos

1998 • 254 citations

Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation.

1994 • 252 citations

Hey genes: a novel subfamily of hairy - and Enhancer of split related genes specifically expressed during mouse embryogenesis

1999 • 249 citations

The function of the neurogenic genes during epithelial development in the Drosophila embryo

1992 • 248 citations

Waves of mouse Lunatic fringe expression, in four-hour cycles at two-hour intervals, precede somite boundary formation

1998 • 244 citations

Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix–loop–helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells

1997 • 236 citations

Neoplastic Transformation by Truncated Alleles of Human NOTCH1/TAN1 and NOTCH2

1997 • 234 citations

Comparative Analysis of the Human and Mouse Hey1 Promoter: Hey Genes Are New Notch Target Genes

2000 • 233 citations

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete.

1994 • 233 citations

Members of the HRT family of basic helix–loop–helix proteins act as transcriptional repressors downstream of Notch signaling

2000 • 231 citations

Specificity for the Hairy/Enhancer of split Basic Helix-Loop-Helix (bHLH) Proteins Maps outside the bHLH Domain and Suggests Two Separable Modes of Transcriptional Repression

1995 • 223 citations

Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy geneDll3are associated with disruption of the segmentation clock within the presomitic mesoderm

2002 • 219 citations

The function of hairy-related bHLH repressor proteins in cell fate decisions

1998 • 218 citations

HERP, a Novel Heterodimer Partner of HES/E(spl) in Notch Signaling

2001 • 211 citations

Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites

2000 • 208 citations

Dynamics of notch expression during murine prostate development and tumorigenesis.

2001 • 202 citations

Dynamic Expression oflunatic fringeSuggests a Link betweennotchSignaling and an Autonomous Cellular Oscillator Driving Somite Segmentation

1999 • 196 citations

Isolation and Functional Analysis of a cDNA for Human Jagged2, a Gene Encoding a Ligand for the Notch1 Receptor

1997 • 192 citations

HERP, a New Primary Target of Notch Regulated by Ligand Binding

2001 • 191 citations

her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling

1999 • 188 citations

Members of the Jagged/Notch Gene Families Are Expressed in Injured Arteries and Regulate Cell Phenotype via Alterations in Cell Matrix and Cell-Cell Interaction

2001 • 186 citations

Rel/NF-κB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

1999 • 185 citations

Hes7: a bHLH‐type repressor gene regulated by Notch and expressed in the presomitic mesoderm

2001 • 185 citations

Human Ligands of the Notch Receptor

1999 • 182 citations

Nrarp is a novel intracellular component of the Notch signaling pathway

2001 • 180 citations

Defective T cell activation and autoimmune disorder in Stra13-deficient mice

2001 • 167 citations

Oscillating Expression of c-Hey2 in the Presomitic Mesoderm Suggests That the Segmentation Clock May Use Combinatorial Signaling through Multiple Interacting bHLH Factors

2000 • 162 citations

Cardiovascular Basic Helix Loop Helix Factor 1, a Novel Transcriptional Repressor Expressed Preferentially in the Developing and Adult Cardiovascular System

2000 • 155 citations

Molecular Interaction between TLE1 and the Carboxyl-Terminal Domain of HES-1 Containing the WRPW Motif

1996 • 154 citations

Molecular Characterization of the Novel Basic Helix–Loop–Helix Protein DEC1 Expressed in Differentiated Human Embryo Chondrocytes

1997 • 153 citations

An Antisense Oligonucleotide to the Notch Ligand Jagged Enhances Fibroblast Growth Factor-induced Angiogenesis in Vitro

1996 • 147 citations

Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation

2000 • 146 citations

The link between integration and expression of human papillomavirus type 16 genomes and cellular changes in the evolution of cervical intraepithelial neoplastic lesions.

1997 • 145 citations

Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notch^ic-Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line

2002 • 142 citations

The Basic Helix-Loop-Helix Transcription Factor HESR1 Regulates Endothelial Cell Tube Formation

2001 • 142 citations

The bHLH Gene Hes1 Regulates Differentiation of Multiple Cell Types

2000 • 142 citations

Identification and Expression of a Novel Family of bHLH cDNAs Related to Drosophila Hairy and Enhancer of Split

1999 • 141 citations

Recombination Signal Sequence Binding Protein Jκ Is Constitutively Bound to the NF-κB Site of the Interleukin-6 Promoter and Acts as a Negative Regulatory Factor

1997 • 140 citations

T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells.

1996 • 136 citations

Reciprocal Regulatory Interactions between the Notch and Ras Signaling Pathways in the Drosophila Embryonic Mesoderm

2002 • 136 citations

The Nrarp Gene Encodes an Ankyrin-Repeat Protein That Is Transcriptionally Regulated by the Notch Signaling Pathway

2001 • 134 citations

EBNA-2 upregulation of Epstein-Barr virus latency promoters and the cellular CD23 promoter utilizes a common targeting intermediate, CBF1

1994 • 132 citations

Structure, Chromosomal Locus, and Promoter of MouseHes2Gene, a Homologue ofDrosophila hairyandEnhancer of split

1998 • 127 citations

Notch Receptors, Partners and Regulators: From Conserved Domains to Powerful Functions

1998 • 125 citations

SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation.

1997 • 120 citations

Enhancer of splitD, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein.

1992 • 117 citations

SHARPs: MammalianEnhancer-of-Split- andHairy-Related Proteins Coupled to Neuronal Stimulation

1997 • 115 citations

Up a Notch

2000 • 114 citations

bHLH proteins encoded by theEnhancer of split complex ofDrosophila negatively interfere with transcriptional activation mediated by proneural genes

1994 • 113 citations

Regulation of STRA13 by the von Hippel-Lindau Tumor Suppressor Protein, Hypoxia, and the UBC9/Ubiquitin Proteasome Degradation Pathway

2001 • 110 citations

Serrate2 is disrupted in the mouse limb-development mutant syndactylism

1997 • 109 citations

HES-1 Repression of Differentiation and Proliferation in PC12 Cells: Role for the Helix 3-Helix 4 Domain in Transcription Repression

2000 • 109 citations

Regulation of the ERBB-2 Promoter by RBPJκ and NOTCH

1997 • 107 citations

Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos

2000 • 107 citations

HERP1 Is a Cell Type-specific Primary Target of Notch

2002 • 105 citations

Notch signaling: direct or what?

1998 • 101 citations

Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix–loop–helix repressor of neuronal differentiation

1997 • 101 citations

The Basic Helix-Loop-Helix Genehesr2Promotes Gliogenesis in Mouse Retina

2001 • 101 citations

Molecular Cloning and Characterization of DEC2, a New Member of Basic Helix-Loop-Helix Proteins

2001 • 97 citations

Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells

1995 • 96 citations

Activated Notch1 Modulates Gene Expression in B Cells Similarly to Epstein-Barr Viral Nuclear Antigen 2

2000 • 93 citations

Characterization of the Human and Mouse HEY1, HEY2, and HEYL Genes: Cloning, Mapping, and Mutation Screening of a New bHLH Gene Family

2000 • 87 citations

DEC1 is a downstream target of TGF-β with sequence-specific transcriptional repressor activities

2002 • 86 citations

The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression

1998 • 83 citations

Identification of Genes Differentially Induced by Hypoxia in Pancreatic Cancer Cells

2001 • 81 citations

Molecular characterization of HES‐2, a mammalian helix‐loop‐helix factor structurally related to Drosophila hairy and Enhancer of split

1993 • 81 citations

The Mammalian Transcriptional Repressor RBP (CBF1) Regulates Interleukin-6 Gene Expression

1997 • 80 citations

Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains.

1992 • 76 citations

A molecular clock involved in Somite segmentation

2001 • 75 citations

Target Specificities of Drosophila Enhancer of split Basic Helix-Loop-Helix Proteins

1999 • 74 citations

Proto‐oncogene of int‐3, a mouse Notch homologue, is expressed in endothelial cells during early embryogenesis

1997 • 70 citations

The role of presenilin 1 during somite segmentation

2001 • 69 citations

Hes6 regulates myogenic differentiation

2002 • 68 citations

Functional dissection of the Drosophila Enhancer of split protein, a suppressor of neurogenesis

1997 • 68 citations

Regulation of Myogenic Terminal Differentiation by the Hairy-related Transcription Factor CHF2

2001 • 67 citations

Two purified factors bind to the same sequence in the enhancer of mouse MHC class I genes: one of them is a positive regulator induced upon differentiation of teratocarcinoma cells

1989 • 65 citations

Generation of Structurally and Functionally Distinct Factors from the Basic Helix-Loop-Helix Gene Hes3 by Alternative First Exons

2000 • 65 citations

Notch4 and Jagged-1 Induce Microvessel Differentiation of Rat Brain Endothelial Cells

2000 • 65 citations

HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program

2001 • 63 citations

Dominant Enhancers of Egfr in Drosophila melanogaster: Genetic Links Between the Notch and Egfr Signaling Pathways

1997 • 61 citations

Well of darkness

1998 • 52 citations

Repression of Activator Protein-1-mediated Transcriptional Activation by the Notch-1 Intracellular Domain

2002 • 47 citations

Notch signaling as a target in multimodality cancer therapy.

2000 • 45 citations

Oh no, Notch again!

2000 • 45 citations

Induction of basic helix-loop-helix protein DEC1 (BHLHB2)/Stra13/Sharp2 in response to the cyclic adenosine monophosphate pathway

2001 • 42 citations

Expression of the helix-loop-helix factor, Hes3, during embryo development suggests a role in early midbrain-hindbrain patterning

1997 • 42 citations

Expression of hes6 , a new member of the Hairy/Enhancer-of-split family, in mouse development

2000 • 39 citations

Clast5/Stra13 Is a Negative Regulator of B Lymphocyte Activation

2002 • 34 citations

Identity of the β-Globin Locus Control Region Binding Protein HS2NF5 as the Mammalian Homolog of the Notch-regulated Transcription Factor Suppressor of Hairless

1998 • 32 citations

Gene Structure and Chromosomal Location of a Human bHLH Transcriptional Factor DEC1-Stra13-SHARP-2/BHLHB2

2001 • 29 citations

Significance of proneural basic helix-loop-helix transcription factors in neuroendocrine differentiation of fetal lung epithelial cells and lung carcinoma cells.

2001 • 29 citations

Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors

2000 • 28 citations

Purification of a novel MHC class I element binding activity from thymus nuclear extracts reveals that thymic RBP-Jkappa/CBF1 binds to NF-kappaB-like elements.

1996 • 22 citations

Transcriptional Regulation of the Human Acid α-Glucosidase Gene

2001 • 17 citations