Notch1 functions as a tumor suppressor in mouse skin

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Wnt signaling and cancer

2000 • 3,215 citations

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

Calcium regulation of growth and differentiation of mouse epidermal cells in culture

1980 • 1,810 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

2001 • 849 citations

Embryonic Lethality and Vascular Defects in Mice Lacking the Notch Ligand Jagged1

1999 • 756 citations

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ERT and Cre-ERT2 recombinases

1999 • 733 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Maintenance of somite borders in mice requires the Delta homologue Dll1

1997 • 623 citations

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

1996 • 497 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

2001 • 477 citations

Wnt Signaling Controls the Phosphorylation Status of β-Catenin

2002 • 464 citations

β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

2001 • 457 citations

Stimulation of human epidermal differentiation by Delta–Notch signalling at the boundaries of stem-cell clusters

2000 • 440 citations

Basal cell carcinomas in mice overexpressing Gli2 in skin

2000 • 396 citations

Alterations in Notch signaling in neoplastic lesions of the human cervix.

1995 • 355 citations

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands.

1992 • 354 citations

The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

1996 • 323 citations

Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality

1999 • 277 citations

Notch as a Mediator of Cell Fate Determination in Hematopoiesis: Evidence and Speculation

1999 • 265 citations

Neoplastic Transformation by Truncated Alleles of Human NOTCH1/TAN1 and NOTCH2

1997 • 234 citations

p21 ^WAF1/Cip1 functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential

1999 • 201 citations

Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis

1999 • 99 citations

Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling

2001 • 84 citations

Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis.

1999 • 66 citations