Integration of TGF-β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

2000 • 3,504 citations

How cells read TGF-β signals

2000 • 1,843 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

The snail superfamily of zinc-finger transcription factors

2002 • 1,665 citations

An Overview of Epithelio-Mesenchymal Transformation

1995 • 1,505 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion

2001 • 1,351 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Transforming Growth Factor-β1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism

2001 • 993 citations

Notch Signaling: From the Outside In

2000 • 958 citations

Notch1 functions as a tumor suppressor in mouse skin

2003 • 957 citations

Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration

2000 • 956 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

The Transforming Growth Factor-βs

1991 • 882 citations

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

2002 • 703 citations

Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis

2002 • 693 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

Transforming Growth Factor β-1 Induces Snail Transcription Factor in Epithelial Cell Lines

2003 • 617 citations

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

2002 • 551 citations

Genetic programs of epithelial cell plasticity directed by transforming growth factor-β

2001 • 520 citations

Multiple sclerosis: Re-expression of a developmental pathway that restricts oligodendrocyte maturation

2002 • 471 citations

p38 mitogen-activated protein kinase is required for TGFβ-mediated fibroblastic transdifferentiation and cell migration

2002 • 431 citations

TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells

1999 • 419 citations

Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning

2001 • 373 citations

Temporal and Distinct TGFβ Ligand Requirements during Mouse and Avian Endocardial Cushion Morphogenesis

2002 • 273 citations

Comparative Analysis of the Human and Mouse Hey1 Promoter: Hey Genes Are New Notch Target Genes

2000 • 233 citations

Members of the HRT family of basic helix–loop–helix proteins act as transcriptional repressors downstream of Notch signaling

2000 • 231 citations

Hierarchical model of gene regulation by transforming growth factor β

2003 • 209 citations

Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses

2003 • 209 citations

Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway

1999 • 207 citations

Tetralogy of Fallot and Other Congenital Heart Defects in Hey2 Mutant Mice

2002 • 185 citations

Slug is an Essential Target of TGFβ2 Signaling in the Developing Chicken Heart

2000 • 180 citations

Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2

2002 • 173 citations

Smad3 and Smad4 Mediate Transcriptional Activation of the Human Smad7 Promoter by Transforming Growth Factor β

2000 • 167 citations

Transforming Growth Factor-β Induces Renal Epithelial Jagged-1 Expression in Fibrotic Disease

2002 • 144 citations

The Basic Helix-Loop-Helix Transcription Factor HESR1 Regulates Endothelial Cell Tube Formation

2001 • 142 citations

TGFβ3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro

1998 • 132 citations

Transforming growth factors β

1989 • 86 citations

Mechanism and Function of Signaling by the TGFβ Superfamily

1998 • 78 citations

Patterning of Drosophila leg sensory organs through combinatorial signaling by Hedgehog, Decapentaplegic and Wingless

1999 • 17 citations