Oxidative stress and cancer: have we moved forward?

Free radicals in biology and medicine

1991 • 17,840 citations

Free radicals, metals and antioxidants in oxidative stress-induced cancer

2006 • 6,281 citations

Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity

2004 • 3,483 citations

Nuclear factor-κB in cancer development and progression

2006 • 3,334 citations

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

2005 • 2,499 citations

Production of large amounts of hydrogen peroxide by human tumor cells.

1991 • 2,465 citations

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

1996 • 2,327 citations

Measuring reactive species and oxidative damagein vivoand in cell culture: how should you do it and what do the results mean?

2004 • 2,159 citations

ROS stress in cancer cells and therapeutic implications

2004 • 1,839 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

p53 Regulates Mitochondrial Respiration

2006 • 1,600 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

The Role of Oxidative Stress in Carcinogenesis

2004 • 1,516 citations

Free Radicals in Biology and Medicine

1986 • 1,339 citations

Triggering and modulation of apoptosis by oxidative stress

2000 • 1,315 citations

Oxidative DNA damage and disease: induction, repair and significance

2004 • 1,304 citations

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

2006 • 1,278 citations

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

2005 • 1,225 citations

Persistent oxidative stress in cancer

1995 • 1,218 citations

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

2005 • 1,102 citations

Oxidative Decay of DNA

1997 • 938 citations

Reactive oxygen species in tumor progression

2005 • 911 citations

Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.

2001 • 860 citations

Superoxide dismutase as a target for the selective killing of cancer cells

2000 • 824 citations

mtDNA mutations increase tumorigenicity in prostate cancer

2005 • 821 citations

Free-Radical-Induced DNA Damage and Its Repair

2006 • 761 citations

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

2003 • 756 citations

Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)

2004 • 724 citations

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

2003 • 719 citations

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

2004 • 644 citations

Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis

2004 • 607 citations

Dietary polyphenols: Good, bad, or indifferent for your health?

2006 • 533 citations

Oxidative stress in cell culture: an under‐appreciated problem?

2003 • 519 citations

What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?

1997 • 480 citations

Mechanisms of Formation, Genotoxicity, and Mutation of Guanine Oxidation Products

2006 • 479 citations

Reactive oxygen generated by Nox1 triggers the angiogenic switch

2002 • 473 citations

Redox signaling in angiogenesis: Role of NADPH oxidase

2006 • 470 citations

Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils

1985 • 443 citations

Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis

2006 • 442 citations

The Nox Family of NAD(P)H Oxidases: Host Defense and Beyond

2004 • 437 citations

Those confounded vitamins: what can we learn from the differences between observational versus randomised trial evidence?

2004 • 429 citations

Artifacts in Cell Culture: Rapid Generation of Hydrogen Peroxide on Addition of (−)-Epigallocatechin, (−)-Epigallocatechin Gallate, (+)-Catechin, and Quercetin to Commonly Used Cell Culture Media

2000 • 394 citations

Evidence that reactive oxygen species do not mediate NF- B activation

2003 • 385 citations

Superoxide dismutases in malignant cells and human tumors

2004 • 372 citations

Reactive Oxygen Species Produced by NAD(P)H Oxidase Inhibit Apoptosis in Pancreatic Cancer Cells

2004 • 355 citations

Historical claims and current interpretations of replicative aging

2002 • 354 citations

When cells get stressed: an integrative view of cellular senescence

2004 • 347 citations

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

2002 • 346 citations

Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective

2005 • 336 citations

When cells get stressed: an integrative view of cellular senescence

2004 • 335 citations

Mechanisms of cellular senescence in human and mouse cells

2004 • 329 citations

Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents

2003 • 322 citations

Increased Nox1 and hydrogen peroxide in prostate cancer

2004 • 317 citations

2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications

2005 • 308 citations

Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma.

1994 • 307 citations

Spontaneous cancer and its possible relationship to oxygen metabolism.

1980 • 298 citations

BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance

2006 • 296 citations

Bacteria-Induced Intestinal Cancer in Mice with DisruptedGpx1andGpx2Genes

2004 • 295 citations

Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel‐induced cancer cell death both in vitro and in vivo

2006 • 295 citations

Akt Signaling and Cancer: Surviving but not Moving On

2006 • 292 citations

Establishing the Significance and Optimal Intake of Dietary Antioxidants: The Biomarker Concept

2009 • 286 citations

Oxidative stress in malignant melanoma and non-melanoma skin cancer

2003 • 285 citations

Lifespan Extension and Rescue of Spongiform Encephalopathy in Superoxide Dismutase 2 Nullizygous Mice Treated with Superoxide Dismutase–Catalase Mimetics

2001 • 285 citations

Lysyl Oxidase Regulates Breast Cancer Cell Migration and Adhesion through a Hydrogen Peroxide–Mediated Mechanism

2005 • 275 citations

Resistance to Paclitaxel Is Proportional to Cellular Total Antioxidant Capacity

2005 • 274 citations

Inflammation-associated cancer: NF-κB is the lynchpin

2005 • 271 citations

Effect of diet on cancer development: is oxidative DNA damage a biomarker?1,2 1This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Miral Dizdaroglu

2002 • 263 citations

Randomized Trial of Antioxidant Vitamins to Prevent Acute Adverse Effects of Radiation Therapy in Head and Neck Cancer Patients

2005 • 255 citations

Antioxidants and Cancer Therapy: A Systematic Review

2004 • 253 citations

Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids

2006 • 252 citations

Oxygen and the control of gene expression

1994 • 245 citations

A threshold concept for cancer therapy

2000 • 245 citations

Free radicals, proteins and DNA: oxidative damage versus redox regulation

1996 • 242 citations

Mechanism of the tumor suppressive effect of MnSOD overexpression

2005 • 229 citations

Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells

2004 • 228 citations

Protein Kinase Cδ Selectively Regulates Protein Kinase D-Dependent Activation of NF-κB in Oxidative Stress Signaling

2004 • 221 citations

TheIn VitroCytotoxicity of Ascorbate Depends on the Culture Medium Used to Perform the Assay and Involves Hydrogen Peroxide

2001 • 218 citations

The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer

2005 • 217 citations

Regulation of reactive oxygen species, DNA damage and c-Myc function by peroxiredoxin 1

2005 • 217 citations

Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.

1984 • 208 citations

Nitrative DNA damage in inflammation and its possible role in carcinogenesis

2005 • 198 citations

Invasive Potential Induced under Long-Term Oxidative Stress in Mammary Epithelial Cells

2004 • 193 citations

No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion in smokers

1997 • 188 citations

Phagocyte-derived reactive species: salvation or suicide?

2006 • 187 citations

Overexpression of manganese or copper–zinc superoxide dismutase inhibits breast cancer growth

2006 • 187 citations

Expression of NOX1, a superoxide‐generating NADPH oxidase, in colon cancer and inflammatory bowel disease

2005 • 187 citations

Oxidative Stress and Tumour Cell Proliferation

1990 • 179 citations

Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications

2003 • 174 citations

Chemistry-based studies on oxidative DNA damage: formation, repair, and mutagenesis

2002 • 172 citations

Inflammation, proteases and cancer

2006 • 168 citations

Elevated Oxidative Stress in Patients with Ataxia Telangiectasia

2002 • 168 citations

Role of oxidative damage in the genotoxicity of arsenic

2004 • 166 citations

Silencing of Peroxiredoxin 2 and Aberrant Methylation of 33 CpG Islands in Putative Promoter Regions in Human Malignant Melanomas

2006 • 166 citations

Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats

1997 • 164 citations

The p53-induced Gene-6 (Proline Oxidase) Mediates Apoptosis through a Calcineurin-dependent Pathway

2005 • 160 citations

Persistent oxidative stress in human colorectal carcinoma, but not in adenoma

1999 • 159 citations

Dietary antioxidants and beneficial effect on oxidatively damaged DNA

2006 • 145 citations

Reactive oxygen signaling and MAPK activation distinguish Epstein–Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma

2004 • 145 citations

Dual Role of Oxidized LDL on the NF-KappaB Signaling Pathway

2004 • 141 citations

Signaling kinases modulated by 4-hydroxynonenal

2004 • 139 citations

Hydrogen Peroxide Stimulates Proliferation and Migration of Human Prostate Cancer Cells through Activation of Activator Protein-1 and Up-regulation of the Heparin Affin Regulatory Peptide Gene

2005 • 135 citations

AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells

2005 • 132 citations

Both oxidative and nitrosative stress are associated with muscle wasting in tumour‐bearing rats

2005 • 125 citations

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor

2005 • 125 citations

Tumor Intracellular Redox Status and Drug Resistance-Serendipity or a Causal Relationship?

2004 • 124 citations

Enhanced bleomycin-induced pulmonary damage in mice lacking extracellular superoxide dismutase

2003 • 121 citations

Expression and Activity of NOX5 in the Circulating Malignant B Cells of Hairy Cell Leukemia

2005 • 114 citations

Hypermethylation, Loss of Expression of Glutathione Peroxidase-3 in Barrett's Tumorigenesis

2005 • 111 citations

Oxidative stress mediates neuronal DNA damage and apoptosis in response to cytosine arabinoside

2001 • 108 citations

Mega-Dose Vitamins and Minerals in the Treatment of Non-Metastatic Breast Cancer: An Historical Cohort Study

2002 • 106 citations

Meta‐analysis: antioxidant supplements for primary and secondary prevention of colorectal adenoma

2006 • 105 citations

ReviewThe Defense Mechanisms in Mammalian Cells against Oxidative Damage in Nucleic Acids and their Involvement in the Suppression of Mutagenesis and Cell Death

2004 • 101 citations

A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis

2005 • 99 citations

Can Apple Antioxidants Inhibit Tumor Cell Proliferation? Generation of H₂O₂during Interaction of Phenolic Compounds with Cell Culture Media

2002 • 97 citations

Different DNA repair strategies to combat the threat from 8-oxoguanine

2006 • 93 citations

Hydrogen Peroxide and the Proliferation of Bhk-21 Cells

1995 • 92 citations

Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia–telangiectasia mice

2004 • 91 citations

Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon

2004 • 89 citations

Chemotherapy Alonevs.Chemotherapy Plus High Dose Multiple Antioxidants in Patients with Advanced Non Small Cell Lung Cancer

2005 • 87 citations

Hydrogen Peroxide Produced by Angiopoietin-1 Mediates Angiogenesis

2006 • 87 citations

Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy

2005 • 86 citations

Molecular biology of prostate-cancer pathogenesis

2006 • 84 citations

Reactive oxygen species-mediated regulation of the Na+–H+ exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers

2005 • 83 citations

A Putative Role for Psoriasin in Breast Tumor Progression

2005 • 83 citations

Cigarette Smoke and Oxidative Stress

2006 • 80 citations

Evidence for Peroxynitrite-Mediated Modifications to p53 in Human Gliomas: Possible Functional Consequences

2001 • 77 citations

NO News is not Necessarily Good News in Cancer

2005 • 75 citations

Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-κB activation and oxidative stress

2006 • 71 citations

2-Methoxyestradiol Does Not Inhibit Superoxide Dismutase

2001 • 70 citations

The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA

2006 • 68 citations

Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes

2005 • 66 citations

Recent Advances in Understanding the Antineoplastic Mechanisms of Farnesyltransferase Inhibitors

2005 • 63 citations

The effect of experimental conditions on the levels of oxidatively modified bases in DNA as measured by gas chromatography-mass spectrometry:

1999 • 62 citations

Prevention of Mammary Tumorigenesis in Acatalasemic Mice by Vitamin E Supplementation

1996 • 61 citations

Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells

2005 • 53 citations

The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Derived Reactive Oxygen Species in the Acquisition of Metastatic Ability of Tumor Cells

2006 • 50 citations

Impairment of antioxidant enzymes, lipid peroxidation and 8-oxo-2′-deoxyguanosine in advanced epithelial ovarian carcinoma of a Spanish community

2005 • 46 citations

Helicobacter pylori infection is associated with oxidatively damaged DNA in human leukocytes and decreased level of urinary 8-oxo-7,8-dihydroguanine

2005 • 46 citations

Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancer

2003 • 42 citations

Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma

2006 • 42 citations

Proteasomal Dysfunction: A Common Feature of Neurodegenerative Diseases? Implications for the Environmental Origins of Neurodegeneration

2006 • 40 citations

Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase

2006 • 37 citations

Biphasic regulation of angiogenesis by reactive oxygen species.

2006 • 37 citations

Redox regulation of matrix metalloproteinase gene family in small cell lung cancer cells

2005 • 29 citations

Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma

2005 • 28 citations

Effect of the reduction of superoxide dismutase 1 and 2 or treatment with α-tocopherol on tumorigenesis in Atm-deficient mice

2006 • 26 citations

Expression of the inducible isoform of nitric oxide synthase in pigment cell lesions of the skin

2000 • 26 citations

Gefitinib (?Iressa?, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells

2004 • 23 citations

Combined loss of expression of O⁶‐methylguanine‐DNA methyltransferase and hMLH1 accelerates progression of hepatocellular carcinoma

2003 • 22 citations

Gene‐specific oxidative DNA damage in Helicobacter pylori–infected human gastric mucosa

2002 • 22 citations

Mechanism of cell death induced by an antioxidant extract of Cratoxylum cochinchinense (YCT) in Jurkat T cells: the role of reactive oxygen species and calcium

2004 • 21 citations

Evidence for attenuated cellular 8-oxo-7,8-dihydro-2′-deoxyguanosine removal in cancer patients

2006 • 19 citations

Pretreatment growth environments alter the sensitivity of tumor cells to cytotoxic agents

2003 • 5 citations

ROS: double-edged sword for leukemic cells

2006 • 5 citations

Oxidative Stress and Cancer Cachexia

2006 • 2 citations