Different DNA repair strategies to combat the threat from 8-oxoguanine

DNA Repair and Mutagenesis

2006 • 4,725 citations

Oxidative DNA damage: mechanisms, mutation, and disease

2003 • 3,028 citations

Gene regulation and DNA damage in the ageing human brain

2004 • 1,826 citations

Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors

2002 • 1,346 citations

DNA MISMATCH REPAIR

2005 • 1,296 citations

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

1999 • 792 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells

2004 • 722 citations

Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.

1992 • 590 citations

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

2002 • 485 citations

Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

1996 • 386 citations

Role of the Angiotensin Type 2 Receptor Gene in Congenital Anomalies of the Kidney and Urinary Tract, CAKUT, of Mice and Men

1999 • 360 citations

The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions.

1988 • 343 citations

Mmh / Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice

2000 • 342 citations

Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.

2001 • 319 citations

Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool.

1992 • 310 citations

Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

2000 • 306 citations

Deficiencies in Mouse Myh and Ogg1 Result in Tumor Predisposition and G to T Mutations in Codon 12 of the K-Ras Oncogene in Lung Tumors

2004 • 292 citations

Base Excision Repair of Oxidative DNA Damage Activated by XPG Protein

1999 • 283 citations

The Mammalian Mismatch Repair Pathway Removes DNA 8-oxodGMP Incorporated from the Oxidized dNTP Pool

2002 • 228 citations

Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption.

2003 • 227 citations

Human Homolog of the MutY Repair Protein (hMYH) Physically Interacts with Proteins Involved in Long Patch DNA Base Excision Repair

2001 • 216 citations

Characterization of a Mammalian Homolog of the Escherichia coli MutY Mismatch Repair Protein

1995 • 194 citations

Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation

1998 • 189 citations

Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner

2005 • 188 citations

Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice

2001 • 186 citations

Functional Expression of hMYH, a Human Homolog of the Escherichia coli MutY Protein

1999 • 171 citations

Accumulation of the Oxidative Base Lesion 8-Hydroxyguanine in DNA of Tumor-Prone Mice Defective in Both the Myh and Ogg1 DNA Glycosylases

2004 • 156 citations

Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase

1999 • 156 citations

hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs

2001 • 141 citations

The Oxidized Deoxynucleoside Triphosphate Pool Is a Significant Contributor to Genetic Instability in Mismatch Repair-Deficient Cells

2003 • 141 citations

Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8‐hydroxyguanine and 8‐hydroxyadenine resulting from oxidative stress

2003 • 137 citations

A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage

2002 • 135 citations

Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells

1999 • 129 citations

Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch

2001 • 129 citations

MutYH (MYH) and colorectal cancer

2005 • 115 citations

High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress

2002 • 115 citations

Induction of Chromosomal Gene Mutations in Escherichia coli by Direct Incorporation of Oxidatively Damaged Nucleotides

1998 • 110 citations

8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis

2006 • 103 citations

Different Effects ofCSAandCSBDeficiency on Sensitivity to Oxidative DNA Damage

2004 • 96 citations

Replication-Associated Repair of Adenine:8-Oxoguanine Mispairs by MYH

2002 • 94 citations

Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA.

2003 • 69 citations

Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis

2005 • 63 citations

Insight into the functional consequences of hMYH variants associated with colorectal cancer: distinct differences in the adenine glycosylase activity and the response to AP endonucleases of Y150C and G365D murine MYH

2004 • 56 citations

Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product

2002 • 52 citations

Myh Deficiency Enhances Intestinal Tumorigenesis in Multiple Intestinal Neoplasia ( Apc Min /+) Mice

2004 • 51 citations

Futile short-patch DNA base excision repair of adenine:8-oxoguanine mispair

2004 • 51 citations

A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA

2005 • 39 citations

MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain

2004 • 35 citations

Mutagenic effects of 2-hydroxy-dATP on replication in a HeLa extract: induction of substitution and deletion mutations

2003 • 30 citations

Base excision repair of adenine/8-oxoguanine mispairs by an aphidicolin-sensitive DNA polymerase in human cell extracts

2002 • 25 citations

Characterization of 2-hydroxyadenine DNA glycosylase activity of Escherichia coli MutY protein

2002 • 19 citations

Mutagenesis Induced by Oxidized DNA Precursors: Roles of Y Family DNA Polymerases in Escherichia coli

2005 • 15 citations