Gefitinib (?Iressa?, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 • 1,484 citations

The EGF receptor family as targets for cancer therapy

2000 • 1,339 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

Activation of protein kinase C by tyrosine phosphorylation in response to H ₂ O ₂

1997 • 610 citations

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1998 • 537 citations

Fully Humanized Neutralizing Antibodies to Interleukin-8 (ABX-IL8) Inhibit Angiogenesis, Tumor Growth, and Metastasis of Human Melanoma

2002 • 350 citations

Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment.

2003 • 333 citations

Requirement of Caspase-3(-like) Protease-mediated Hydrogen Peroxide Production for Apoptosis Induced by Various Anticancer Drugs

1998 • 271 citations

TACE is required for the activation of the EGFR by TGF-α in tumors

2003 • 270 citations

Interaction between Protein Kinase C δ and the c-Abl Tyrosine Kinase in the Cellular Response to Oxidative Stress

2000 • 199 citations

Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family.

1994 • 191 citations

Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor α-converting Enzyme and Amphiregulin

2003 • 172 citations

CPT‐11 plus cisplatin in patients with advanced, untreated gastric or gastroesophageal junction carcinoma

2002 • 166 citations

ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non–small cell lung cancer

2002 • 138 citations

Epidermal Growth Factor Receptor Activation under Oxidative Stress Fails to Promote c-Cbl Mediated Down-regulation

2002 • 106 citations

Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells.

1998 • 106 citations

CPT-11 in gastrointestinal cancer

1999 • 97 citations

Co-expression of heparin-binding EGF-like growth factor and related peptides in human gastric carcinoma

1996 • 76 citations

Hydrogen peroxide promotes transformation of rat liver non‐neoplastic epithelial cells through activation of epidermal growth factor receptor

2001 • 75 citations

The Stress- and Inflammatory Cytokine-induced Ectodomain Shedding of Heparin-binding Epidermal Growth Factor-like Growth Factor Is Mediated by p38 MAPK, Distinct from the 12-O-Tetradecanoylphorbol-13-acetate- and Lysophosphatidic Acid-induced Signaling Cascades

2003 • 71 citations

Epidermal growth factor receptor mediates stress-induced expression of its ligands in rat gastric epithelial cells

2001 • 47 citations

Expression of heregulin α, erbB2, and erbB3 and their influences on proliferation of gastric epithelial cells

1999 • 44 citations

Gastrin induces CXC chemokine expression in gastric epithelial cells through activation of NF-κB

2001 • 33 citations

Expression of protein kinase C ?1 confers resistance to TNF?- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells

2001 • 27 citations

Development of ZD1839 in colorectal cancer

2003 • 25 citations

Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drug-resistant sublines

2002 • 23 citations