A threshold concept for cancer therapy

Free radicals in biology and medicine

1991 • 17,840 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase

1974 • 1,109 citations

Doxorubicin cardiotoxicity: analysis of prevailing hypotheses

1990 • 688 citations

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

1980 • 628 citations

Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity

1990 • 512 citations

Reactive oxygen species in tumorigenesis.

1994 • 479 citations

Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.

1993 • 479 citations

Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity.

1997 • 451 citations

Free Radicals in Cutaneous Biology

1994 • 396 citations

Oxygen-derived radicals: a link between reperfusion injury and inflammation.

1987 • 389 citations

Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage

1990 • 364 citations

Antioxidant Defense Mechanisms in Murine Epidermis and Dermis and Their Responses to Ultraviolet Light

1993 • 360 citations

Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation

1993 • 351 citations

Free radicals and antioxidants in chemotherapyinduced toxicity

1997 • 331 citations

Oxidative stress to DNA, protein, and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo(a)pyrene

1997 • 187 citations

Skin Inflammation: Reactive Oxygen Species and the Role of Iron

1992 • 185 citations

Protective roles of cytokines against radiation: Induction of mitochondrial MnSOD

1995 • 172 citations

Successful treatment of radiation-induced fibrosis using and Mn-SOD: An experimental study

1996 • 157 citations

The toxicity of high-dose superoxide dismutase suggests that superoxide can both initiate and terminate lipid peroxidation in the reperfused heart☆

1994 • 148 citations

Manganese superoxide dismutase is induced by IFN-gamma in multiple cell types. Synergistic induction by IFN-gamma and tumor necrosis factor or IL-1.

1991 • 140 citations

Dexrazoxane in the Prevention of Doxorubicin-Induced Cardiotoxicity

1994 • 135 citations

The cardioprotective effect of Mn-superoxide dismutase is lost at high doses in the postischemic isolated rabbit heart

1990 • 132 citations

Sensitization of human renal cell carcinoma cells to cis-diamminedichloroplatinum(II) by anti-interleukin 6 monoclonal antibody or anti-interleukin 6 receptor monoclonal antibody.

1995 • 127 citations

Antioxidant inhibitors for cancer therapy

1998 • 125 citations

Local application of γ-linolenic acid in the treatment of human gliomas

1995 • 111 citations

Enhanced skin carcinogenesis in transgenic mice with high expression of glutathione peroxidase or both glutathione peroxidase and superoxide dismutase.

1997 • 108 citations

Lipid Peroxides in the Polychemotherapy of Cancer Patients

1994 • 96 citations

Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity

1994 • 95 citations

Manganese superoxide dismutase expression in human central nervous system tumors.

1996 • 91 citations

Inhibition of the Induction of Cancer by Antioxidants

1995 • 91 citations

A novel cancer therapy based on oxygen radicals.

1995 • 89 citations

Hydrogen Peroxide in Relation to Proliferation and Apoptosis in BHK-21 Hamster Fibroblasts

1996 • 87 citations

Bleomycin pulmonary toxicity: current status and future directions.

1992 • 78 citations

Reactivity of a monoclonal antibody to manganese superoxide dismutase with human ovarian carcinoma.

1990 • 71 citations

Induction of Cytotoxic Oxidative Stress by<scp>d</scp>-Alanine in Brain Tumor Cells ExpressingRhodotorula gracilis<scp>d</scp>-Amino Acid Oxidase: A Cancer Gene Therapy Strategy

1998 • 71 citations

Expression of manganese superoxide dismutase reduces tumor control radiation dose: gene-radiotherapy.

1995 • 70 citations

Manganese superoxide dismutase expression correlates with p53 status and local recurrence of cervical carcinoma treated with radiation therapy.

1996 • 68 citations

Radiation-induced clastogenic factors: Anticlastogenic effect of ginkgo biloba extract

1995 • 67 citations

Role of intracellular SOD in protecting human leukemic and cancer cells against superoxide and radiation

1994 • 60 citations

Differential Regulation of Manganese Superoxide Dismutase Activity by Alcohol and TNF in Human Hepatoma Cells

1995 • 59 citations

The role of active oxygen species and lipid peroxidation in the antitumor effect of hyperthermia.

1993 • 58 citations

Free radical-dependent suppression of growth of mouse myeloma cells by α-linolenic and eicosapentaenoic acids in vitro

1995 • 50 citations

Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells

1997 • 47 citations

Tumor resistance to oxidative stress: Association with ras oncogene expression and reversal by lovastatin, an inhibitor of p21ras isoprenylation

1995 • 44 citations

Elevated serum manganese superoxide dismutase in acute leukemias

1992 • 41 citations

Oxygen free radicals stimulate fibroblast proliferation

1989 • 40 citations

Prevention of radioinduced cystitis by orgotein: a randomized study.

1996 • 39 citations

Protective role of manganese superoxide dismutase against cigarette smoke‐induced cytotoxicity

1994 • 37 citations

Differential proliferative responses of Syrian hamster embryo fibroblasts to paraquat-generated superoxide radicals depending on tumor suppressor gene function.

1994 • 37 citations

Efficacy of Intralesionaliy Administered Cisplatin-impregnated Biodegradable Polymer for the Treatment of 9L Gliosarcoma in the Rat

1996 • 32 citations

Antitumor effect of ischemia-reperfusion injury induced by transient embolization.

1994 • 31 citations

Endogenous tumor necrosis factor functions as a resistant factor against adriamycin

1994 • 28 citations

Tumor necrosis factor and lymphotoxin: Protection against oxidative stress through induction of MnSOD

1996 • 28 citations

Cytotoxicity and manganese superoxide dismutase induction by tumor necrosis factor-alpha and ionizing radiation in MCF-7 human breast carcinoma cells.

1993 • 27 citations

Stimulated human leukocytes cause activating mutations in the K-ras proto-oncogene

1997 • 22 citations

158Prevention of radioinduced cystitis by orgotein. A randomized study

1996 • 19 citations

Intralesionally implanted cisplatin cures primary brain tumor in rats

1997 • 18 citations

Evaluation of piroxantrone in women with metastatic breast cancer and failure on nonanthracycline chemotherapy

1994 • 17 citations

Reactivity of a monoclonal antibody to manganese superoxide dismutase with human ovarian carcinoma

1990 • 15 citations

Effect of treatment with LHRH analogs containing cytotoxic radicals on the binding characteristics of receptors for luteinizing-hormone-releasing hormone in MXT mouse mammary carcinoma

1993 • 9 citations

Synergic Lung Changes in Rats Receiving Combined Exposure to Paraquat and Ionizing Radiation

1993 • 6 citations

Detection of an Increase in Ascorbate Radical in an Irradiated Experimental Tumour System Using ESR

1995 • 6 citations

Intralesionally implanted cisplatin plus systemic carmustine for the treatment of brain tumor in rats

1998 • 3 citations