Mechanism of the tumor suppressive effect of MnSOD overexpression

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation

1998 • 1,162 citations

Role of superoxide dismutase in cancer: a review.

1979 • 976 citations

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

2003 • 719 citations

Redox regulation of transcriptional activators

1996 • 690 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1

1998 • 580 citations

Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases

1996 • 491 citations

Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.

1993 • 479 citations

Big Mitogen-activated Protein Kinase 1 (BMK1) Is a Redox-sensitive Kinase

1996 • 445 citations

Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer.

1999 • 407 citations

Free radicals, aging, and degenerative diseases

1987 • 375 citations

The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase.

2000 • 324 citations

Free radicals in aging

1988 • 314 citations

Free radicals, aging, and degenerative diseases

1986 • 311 citations

Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase.

1995 • 244 citations

Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase

1997 • 238 citations

Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma.

1991 • 233 citations

Role of antioxidant enzymes in cell immortalization and transformation

1988 • 190 citations

Human Mitochondrial Manganese Superoxide Dismutase Polymorphic Variant Ile58Thr Reduces Activity by Destabilizing the Tetrameric Interface^,

1996 • 182 citations

Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts.

1996 • 158 citations

Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype

1998 • 150 citations

Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway.

1996 • 148 citations

Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells.

1996 • 146 citations

Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase

1992 • 145 citations

Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase.

2003 • 140 citations

Transfection and Expression of MnSOD cDNA Decreases Tumor Malignancy of Human Oral Squamous Carcinoma SCC-25 Cells

1997 • 140 citations

Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase.

1994 • 139 citations

Mitochondrial or cytosolic catalase reverses the MnSOD-dependent inhibition of proliferation by enhancing respiratory chain activity, net ATP production, and decreasing the steady state levels of H2O2

2000 • 135 citations

SOD2: A new type of tumor‐suppressor gene?

1992 • 132 citations

Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells

1999 • 129 citations

Inhibition of AP‐1 and NF‐κB by manganese‐containing superoxide dismutase in human breast cancer cells

1998 • 110 citations

Redox Regulation of Pancreatic Cancer Cell Growth: Role of Glutathione Peroxidase in the Suppression of the Malignant Phenotype

2004 • 109 citations

Free radicals cancer and aging

1986 • 105 citations

Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype.

1999 • 104 citations

Inhibition of cell growth in NIH/3T3 fibroblasts by overexpression of manganese superoxide dismutase: Mechanistic studies

1998 • 72 citations

Decreased Expression of Manganese Superoxide Dismutase in Transformed Cells Is Associated with Increased Cytosine Methylation of the SOD2 Gene

1999 • 70 citations

Superoxide dismutase activity in WI-38 cell cultures: effects of age, trypsinization and SV-40 transformation.

1974 • 67 citations

Superoxide dismutase induces differentiation of friend erythroleukemia cells

1989 • 67 citations

Correlation between the loss of the transformed phenotype and an increase in superoxide dismutase activity in a revertant subclone of sarcoma virus-infected mammalian cells.

1982 • 65 citations

Inhibition of oral cancer cell growth by adenovirusMnSOD plus BCNU treatment

2003 • 55 citations

Evidence of allelic imbalance of chromosome 6 in human astrocytomas

1994 • 43 citations

Paradoxical effects of thiol reagents on Jurkat cells and a new thiol-sensitive mutant form of human mitochondrial superoxide dismutase.

2003 • 42 citations

Potent Anti-tumor Effects of an Active Site Mutant of Human Manganese-Superoxide Dismutase

2004 • 41 citations

Suppression of tumor metastasis by manganese superoxide dismutase is associated with reduced tumorigenicity and elevated fibronectin

1997 • 29 citations

Nitric oxide enhances the manganese superoxide dismutase-dependent suppression of proliferation in HT-1080 fibrosarcoma cells.

1999 • 20 citations

Effects of endothelial nitric oxide synthase gene expression on the tumor biology of human oral carcinoma SCC-25 cells.

1998 • 18 citations