Hydrogen Peroxide Produced by Angiopoietin-1 Mediates Angiogenesis

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

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2002 • 2,258 citations

Reactive Oxygen Species in the Vasculature

2003 • 1,052 citations

Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family

2001 • 662 citations

Angiopoietin-1 Regulates Endothelial Cell Survival Through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

2000 • 623 citations

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2002 • 464 citations

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2000 • 413 citations

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2004 • 400 citations

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2000 • 387 citations

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2003 • 311 citations

Regulation of Endothelial Cell Survival and Apoptosis During Angiogenesis

2002 • 274 citations

Redox signaling in vascular angiogenesis1,2 1Guest Editor: Toshikazu Yoshikawa 2This article is part of a series of reviews on “Vascular Dysfunction and Free Radicals.” The full list of papers may be found on the homepage of the journal.

2002 • 262 citations

Direct Cell Adhesion to the Angiopoietins Mediated by Integrins

2001 • 262 citations

COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity

2004 • 251 citations

Angiopoietin-1 Induces Endothelial Cell Sprouting Through the Activation of Focal Adhesion Kinase and Plasmin Secretion

2000 • 249 citations

Rac1 inhibits TNF‐α‐induced endothelial cell apoptosis: dual regulation by reactive oxygen species

2000 • 230 citations

Sequential Activation of Phosphatidylinositol 3-Kinase, βPix, Rac1, and Nox1 in Growth Factor-Induced Production of H₂O₂

2004 • 223 citations

A Role for Reactive Oxygen Species in Endothelial Cell Anoikis

1999 • 195 citations

Angiopoietin-1 and Its Receptor Tie-2 Participate in the Regulation of Capillary-like Tubule Formation and Survival of Endothelial Cells

1999 • 191 citations

Angiopoietin-1 Promotes Cardiac and Skeletal Myocyte Survival Through Integrins

2005 • 190 citations

Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors.

2003 • 187 citations

Angiopoietin-1 and Angiopoietin-2 Share the Same Binding Domains in the Tie-2 Receptor Involving the First Ig-like Loop and the Epidermal Growth Factor-like Repeats

2003 • 180 citations

Angiogenic Actions of Angiopoietin-1 Require Endothelium-Derived Nitric Oxide

2003 • 179 citations

Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1

2005 • 170 citations

A novel angiogenic factor derived from Aloe vera gel: beta-sitosterol, a plant sterol.

1999 • 154 citations

Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis

2004 • 142 citations

Long-Term and Sustained COMP-Ang1 Induces Long-Lasting Vascular Enlargement and Enhanced Blood Flow

2005 • 128 citations

Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells

2004 • 127 citations

Reactive oxygen species stimulated human hepatoma cell proliferation via cross-talk between PI3-K/PKB and JNK signaling pathways

2002 • 120 citations

Roles of reactive oxygen species in angiopoietin‐1/tie‐2 receptor signaling

2005 • 119 citations

Protein Kinase B Activation by Reactive Oxygen Species Is Independent of Tyrosine Kinase Receptor Phosphorylation and Requires Src Activity

2003 • 118 citations

Angiopoietin-1, Unlike Angiopoietin-2, Is Incorporated into the Extracellular Matrix via Its Linker Peptide Region

2001 • 112 citations

Angiopoietin‐1 activates both anti‐ and proapoptotic mitogen‐activated protein kinases

2003 • 110 citations

Regulation of Angiogenesis by Vascular Endothelial Growth Factor and Angiopoietin-1 in the Rat Aorta Model

2002 • 93 citations

A Unique Autophosphorylation Site on Tie2/Tek Mediates Dok-R Phosphotyrosine Binding Domain Binding and Function

2003 • 85 citations

Tie-2–dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1

2003 • 69 citations

Differential regulation of VEGF, HIF1α and angiopoietin‐1, ‐2 and ‐4 by hypoxia and ionizing radiation in human glioblastoma

2004 • 66 citations

Interleukin-1β Regulates Angiopoietin-1 Expression in Human Endothelial Cells

2004 • 62 citations

Biomedical significance of endothelial cell specific growth factor, angiopoietin

2002 • 61 citations

The angiopoietin–tie2 system in coronary artery endothelium prevents oxidized low-density lipoprotein-induced apoptosis

2001 • 35 citations

Matrix metalloproteinase-2 and -9 expression increases inMycoplasma-infected airways but is not required for microvascular remodeling

2004 • 35 citations