Locus control regions: overcoming heterochromatin-induced gene inactivation in mammals

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

1990 • 554 citations

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

1990 • 508 citations

Transcription complex stability and chromatin dynamics in vivo

1995 • 488 citations

The Phenomenon of Position Effect

1950 • 436 citations

THE EFFECTS OF UNEQUAL CROSSING OVER AT THE BAR LOCUS IN DROSOPHILA

1925 • 432 citations

A developmentally stable chromatin structure in the human beta-globin gene cluster.

1986 • 391 citations

Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1989 • 385 citations

Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation

1996 • 373 citations

Position effect variegation at fission yeast centromeres

1994 • 332 citations

Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription

1996 • 328 citations

Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect.

1988 • 320 citations

Detailed analysis of the site 3 region of the human beta-globin dominant control region.

1990 • 320 citations

The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

1992 • 318 citations

The beta-globin dominant control region: hypersensitive site 2.

1990 • 295 citations

Enhancers increase the probability but not the level of gene expression.

1995 • 293 citations

Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice.

1990 • 289 citations

The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects.

1993 • 280 citations

A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice

1993 • 275 citations

A sequence motif found in aDrosophilaheterochromatin protein is conserved in animals and plants

1991 • 273 citations

Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.

1994 • 267 citations

β-Globin gene inactivation by DNA translocation in γβ-thalassaemi

1983 • 266 citations

Position-effect variegation and the new biology of heterochromatin

1994 • 244 citations

Extension of chromatin accessibility by nuclear matrix attachment regions

1997 • 237 citations

The 5′HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites.

1991 • 231 citations

A dominant chromatin-opening activity in 5′ hypersensitive site 3 of the human beta-globin locus control region.

1996 • 220 citations

Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice.

1993 • 214 citations

Transcriptional regulation of multigene loci: multilevel control

1993 • 187 citations

γ-β-Thalassaemia studies showing that deletion of the γ- and δ-genes influences β-globin gene expression in man

1980 • 184 citations

Position-dependent variegation of globin transgene expression in mice.

1995 • 159 citations

Tissue-specific factors additively increase the probability of the all-or-none formation of a hypersensitive site.

1996 • 156 citations

Variegated transgene expression in mouse mammary gland is determined by the transgene integration locus.

1996 • 153 citations

Hypersensitive site 4 of the human β globin locus control region

1991 • 141 citations

Germ Line Transmission of a Yeast Artificial Chromosome Spanning the Murine α ₁ (I) Collagen Locus

1993 • 118 citations

A locus control region in the T cell receptor α/δ locus

1994 • 109 citations

Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator

1994 • 108 citations

Dosage‐dependent modification of position‐effect variegation in Drosophla

1996 • 107 citations

Site-independent expression of the chicken βA-globin gene in transgenic mice

1990 • 106 citations

Molecular mechanisms of cellular determination: their relation to chromatin structure and parental imprinting

1994 • 80 citations

High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region.

1992 • 78 citations

A 3′ transcriptional enhancer regulates tissue-specific expression of the human CD2 gene.

1990 • 72 citations

Chromatin domains as potential units of eukaryotic gene function

1994 • 72 citations

The beta-globin locus control region enhances transcription of but does not confer position-independent expression onto the lacZ gene in transgenic mice.

1996 • 69 citations

Dissecting a Locus Control Region: Facilitation of Enhancer Function by Extended Enhancer-Flanking Sequences

1995 • 68 citations

Far upstream regions of class II MHC Ea are necessary for position-independent, copy-dependent expression of Ea transgene

1993 • 56 citations

The 5′ flanking region of the rat LAP (C/EBPβ) gene can direct high-level, position-independent, copy number dependent expression in multiple tissues in transgenic mice

1994 • 56 citations

POSITION EFFECTS ON GENES

1936 • 55 citations

Random activation of a transgene under the control of a hybrid hCD2 locus control region/Ig enhancer regulatory element.

1995 • 52 citations

Mosaic expression of an Hprt transgene integrated in a region of Y heterochromatin

1994 • 25 citations

Modelling the Activity of theUltrabithoraxParasegment-specific Regulatory Domains Around Their Anterior Boundaries

1997 • 4 citations