Position-effect variegation and the new biology of heterochromatin

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

1993 • 795 citations

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

1991 • 700 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.

1991 • 566 citations

Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast.

1993 • 506 citations

Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.

1993 • 463 citations

Types of visible variations induced by X-rays inDrosophila

1930 • 462 citations

Repetitive DNA sequences in Drosophila

1971 • 458 citations

Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication

1993 • 435 citations

DNA position-specific repression of transcription by a Drosophila zinc finger protein.

1992 • 418 citations

Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dp1187 by single P element insertional mutagenesis.

1992 • 403 citations

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres

1993 • 392 citations

A group of scs elements function as domain boundaries in an enhancer-blocking assay.

1992 • 383 citations

Position effect variegation at fission yeast centromeres

1994 • 332 citations

Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect.

1988 • 320 citations

The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

1992 • 318 citations

Origin Recognition Complex (ORC) in Transcriptional Silencing and DNA Replication in S. cerevisiae

1993 • 314 citations

Position effect variegation and chromatin proteins

1992 • 311 citations

Silencers, silencing, and heritable transcriptional states

1992 • 296 citations

RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae.

1993 • 283 citations

The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects.

1993 • 280 citations

Saccharomyces telomeres assume a non-nucleosomal chromatin structure.

1992 • 275 citations

Spatial organization of chromosomes in the salivary gland nuclei of Drosophila melanogaster.

1986 • 270 citations

A position effect on the time of replication origin activation in yeast

1992 • 263 citations

Preferential transposition of Drosophila P elements to nearby chromosomal sites.

1993 • 253 citations

A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere.

1992 • 247 citations

C-Terminal Truncation of RAP1 Results in the Deregulation of Telomere Size, Stability, and Function in Saccharomyces cerevisiae

1992 • 233 citations

Association of fragile X syndrome with delayed replication of the FMR1 gene

1993 • 233 citations

Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster.

1992 • 231 citations

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing

1993 • 231 citations

Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein

1990 • 229 citations

Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo.

1992 • 227 citations

The effects of chromosome rearrangements on the expression of heterochromatic genes in chromosome 2L of Drosophila melanogaster.

1990 • 212 citations

Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast

1993 • 207 citations

polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila.

1993 • 200 citations

Distortion of the DNA Double Helix by RAP1 at Silencers and Multiple Telomeric Binding Sites

1993 • 198 citations

The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis.

1993 • 195 citations

Active genes in budding yeast display enhanced in vivo accessibility to foreign DNA methylases: a novel in vivo probe for chromatin structure of yeast.

1992 • 188 citations

Scaffold attachment regions increase reporter gene expression in stably transformed plant cells.

1993 • 175 citations

Drosophila ribosomal RNA genes function as an X-Y pairing site during male meiosis

1990 • 174 citations

A Drosophila rRNA gene located in euchromatin is active in transcription and nucleolus formation.

1988 • 171 citations

Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity

1993 • 162 citations

Cell Cycle-Dependent Distribution of Telomeres, Centromeres, and Chromosome-Specific Subsatellite Domains in the Interphase Nucleus of Mouse Lymphocytes

1993 • 161 citations

Viable deletions of a telomere from a Drosophila chromosome

1989 • 151 citations

An Origin of DNA Replication and a Transcription Silencer Require a Common Element

1992 • 143 citations

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.

1992 • 141 citations

Reduced DNA polytenization of a minichromosome region undergoing position-effect variegation in Drosophila

1990 • 133 citations

Telomeres and the functional architecture of the nucleus

1993 • 132 citations

The role of heterochromatin in the expression of a heterochromatic gene, the rolled locus of Drosophila melanogaster.

1993 • 127 citations

Efficient and dispersed local P element transposition from Drosophila females.

1993 • 124 citations

Boundary functions in the control of gene expression

1991 • 118 citations

Mechanisms of heritable gene repression during development of Drosophila

1993 • 113 citations

DNA OF DROSOPHILA CHROMOSOMES

1973 • 109 citations

Unusual kinetochores and chromatin diminution in Parascaris

1989 • 105 citations

Chapter 22 Position-Effect Variegation—An Assay for Nonhistone Chromosomal Proteins and Chromatin Assembly and Modifying Factors

1991 • 104 citations

Overlapping domains of the heterochromatin-associated protein HP1 mediate nuclear localization and heterochromatin binding.

1993 • 95 citations

Chromosome structure at interfaces between major chromatin types: Alpha‐ and Beta‐heterochromatin

1990 • 94 citations

The effect of modifiers of position-effect variegation on the variegation of heterochromatic genes of Drosophila melanogaster.

1991 • 93 citations

Position effect and related phenomena

1992 • 91 citations

Silencers, silencing, and heritable transcriptional states.

1992 • 78 citations

Elimination of Tec elements involves a novel excision process.

1993 • 67 citations

Cell lineage-specific expression of modulo, a dose-dependent modifier of variegation in Drosophila.

1992 • 65 citations

Chromosomal structure is altered by mutations that suppress or enhance position effect variegation

1990 • 63 citations

Modification of the Drosophila heterochromatic mutation brownDominant by linkage alterations.

1994 • 63 citations

Sixty years of mystery.

1990 • 63 citations

Cloning and expression of Drosophila HP1 homologs from a mealybug, Pianococcus citri

1992 • 62 citations

Telomeric position effect in yeast

1992 • 54 citations

Cytogenetic and molecular aspects of position effect variegation in Drosophila melanogaster

1991 • 54 citations

Cytogenetic and molecular aspects of position-effect variegation in Drosophila melanogaster

1993 • 54 citations

P transposon-induced dominant enhancer mutations of position-effect variegation in Drosophila melanogaster.

1993 • 52 citations

Evolutionary conservation of developmental mechanisms

1993 • 48 citations

Molecular and cytogenetic analysis of the heterochromatin-euchromatin junction region of the Drosophila melanogaster X chromosome using cloned DNA sequences.

1990 • 46 citations

A heat shock-activated cDNA rescues the recessive lethality of mutations in the heterochromatin-associated protein HP1 of Drosophila melanogaster

1993 • 44 citations

Silencing: the establishment and inheritance of stable, repressed transcription states

1992 • 43 citations

Cytogenetic and molecular aspects of position effect variegation in Drosophila

1991 • 43 citations

A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogaster.

1992 • 42 citations

Somatic instability of a Drosophila chromosome.

1992 • 37 citations

Replication forks are not found in a Drosophila minichromosome demonstrating a gradient of polytenization

1992 • 37 citations

Heterochromatin protein 1, a known suppressor of position-effect variegation, is highly conserved inDrosophila

1992 • 36 citations

Protein phosphorylation is involved in the regulation of chromatin condensation during interphase

1992 • 27 citations

Mapping of a mouse homolog of a Heterochromatin protein gene to the X Chromosome

1991 • 21 citations

A cytogenetic analysis of chromosomal region 31 of Drosophila melanogaster.

1993 • 20 citations

Position Effect Variegation and Genomic Instability

1993 • 20 citations

Evidence for intrinsic differences in the formation of chromatin domains in Drosophila melanogaster.

1992 • 18 citations

Restructing of DNA sequences in the germline genome of Oxytricha

1993 • 5 citations