Hypersensitive site 4 of the human β globin locus control region

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.

1990 • 629 citations

An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.

1988 • 518 citations

Megakaryocytic and erythrocytic lineages share specific transcription factors

1990 • 446 citations

Erythroid-specific expression of human beta-globin genes in transgenic mice.

1985 • 436 citations

Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.

1990 • 422 citations

The Molecular Genetics of Human Hemoglobin

1984 • 420 citations

Bidirectional SV40 Transcription Mediated by Tandem Sp1 Binding Interactions

1985 • 413 citations

The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein.

1988 • 362 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene

1989 • 326 citations

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.

1990 • 322 citations

Detailed analysis of the site 3 region of the human beta-globin dominant control region.

1990 • 320 citations

The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

1989 • 302 citations

The beta-globin dominant control region: hypersensitive site 2.

1990 • 295 citations

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.

1989 • 280 citations

Regulated expression of human Aγ-, β-, and hybrid γβ-globin genes in transgenic mice: Manipulation of the developmental expression patterns

1986 • 275 citations

Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene.

1989 • 272 citations

β-Globin gene inactivation by DNA translocation in γβ-thalassaemi

1983 • 266 citations

Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites.

1989 • 240 citations

Molecular analysis of the human beta-globin locus activation region.

1989 • 218 citations

The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription.

1988 • 211 citations

DNasel hypersensitive sites 1, 2 and 3 of the human β-globin dominant control region direct position-independent expression

1990 • 186 citations

γ-β-Thalassaemia studies showing that deletion of the γ- and δ-genes influences β-globin gene expression in man

1980 • 184 citations

Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein

1990 • 140 citations

In vitro binding of several cell-specific and ubiquitous nuclear proteins to the GT-I motif of the SV40 enhancer.

1987 • 127 citations

Site-independent expression of the chicken βA-globin gene in transgenic mice

1990 • 106 citations

Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene.

1987 • 104 citations

γδβ-Thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human β-globin cluster

1986 • 95 citations

High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.

1989 • 83 citations