Far upstream regions of class II MHC Ea are necessary for position-independent, copy-dependent expression of Ea transgene

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

NUCLEASE HYPERSENSITIVE SITES IN CHROMATIN

1988 • 1,233 citations

The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I

1980 • 1,114 citations

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

1985 • 1,052 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

Comparison of three actin-coding sequences in the mouse; Evolutionary relationships between the actin genes of warm-blooded vertebrates

1986 • 678 citations

The class II molecules of the human and murine major histocompatibility complex

1984 • 664 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

Active chromatin

1982 • 549 citations

Sequences and Factors: A Guide to MHC Class-II Transcription

1992 • 540 citations

Autoradiography using storage phosphor technology

1990 • 531 citations

A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

1990 • 477 citations

Regulation of Major Histocompatibility Complex Class-II Genes: X, Y and Other Letters of the Alphabet

1990 • 470 citations

DNAase I-hypersensitive sites of chromatin

1981 • 410 citations

Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens.

1992 • 407 citations

The formation and function of DNase I hypersensitive sites in the process of gene activation.

1988 • 394 citations

A developmentally stable chromatin structure in the human beta-globin gene cluster.

1986 • 391 citations

Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1989 • 385 citations

Position Effects on Eukaryotic Gene Expression

1990 • 377 citations

DNA CONFORMATION AND PROTEIN BINDING

1989 • 343 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.

1991 • 335 citations

Gene organization and recombinational hotspots in the murine major histocompatibility complex

1986 • 312 citations

Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice.

1990 • 289 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins.

1992 • 259 citations

Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.

1983 • 245 citations

Effects of different DNA polymerases in ligation-mediated PCR: enhanced genomic sequencing and in vivo footprinting.

1992 • 232 citations

Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins.

1987 • 212 citations

Compartmentalization of MHC class II gene expression in transgenic mice

1988 • 201 citations

The murine Eα immune response gene

1983 • 180 citations

Correcting an immune-response deficiency by creating Eα gene transgenic mice

1985 • 171 citations

Variable synthesis and expression of E β and A e (E β ) Ia polypeptide chains in mice of differentH-2 haplotypes

1981 • 165 citations

Cell type-specific enhancer element associated with a mouse MHC gene, Eβ

1984 • 162 citations

Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: An in vivo approach to investigate la gene function

1987 • 134 citations

Functional expression of a microinjected Edα gene in C57BL/6 transgenic mice

1985 • 126 citations

Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region.

1992 • 117 citations

HMGs everywhere

1992 • 99 citations

Isolation and characterization of a cDNA clone for the murine I-E beta polypeptide chain.

1983 • 81 citations

In Vitro Analysis of Murine B-Cell Development

1985 • 80 citations

Tissue-specific, inducible and functional expression of the E alpha d MHC class II gene in transgenic mice.

1985 • 70 citations

Identification of cis Sequences Controlling Efficient PositionIndependent Tissue-Specific Expression of Human Major Histocompatibility Complex Class I Genes in Transgenic Mice

1991 • 53 citations

Tissue-specific and cell surface expression of human major histocompatibility complex class I heavy (HLA-B7) and light (beta 2-microglobulin) chain genes in transgenic mice.

1988 • 51 citations

Eo: a history of a mutation.

1984 • 45 citations

A linkage map of the mouse immunoglobulin lambda light chain locus

1989 • 44 citations

Silencing: the establishment and inheritance of stable, repressed transcription states

1992 • 43 citations

Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene.

1989 • 41 citations

Fetal Liver Pro-B and Pre-B Lymphocyte Clones: Expression of Lymphoid-Specific Genes, Surface Markers, Growth Requirements, Colonization of the Bone Marrow, and Generation of B Lymphocytes In Vivo and In Vitro

1992 • 39 citations

Immune deficiency due to high copy numbers of an Ak beta transgene.

1990 • 38 citations

Restricted assembly of MHC class II molecules in transgenic mice.

1989 • 30 citations

Selective expression of class II E alpha d gene in transgenic mice.

1989 • 24 citations

Molecular organization of the class II genes of the human and mouse major histocompatibility complexes.

1986 • 18 citations

In vivo expression and function of hybrid Ia dimers (E alpha A beta) in recombinant and transgenic mice.

1989 • 17 citations

Fine-tuning of MHC class II gene expression in defined microenvironments

1989 • 16 citations

Inherited Immunodeficiency with a Defect in a Major Histocompatibility Complex Class II Promoter-Binding Protein Differs in the Chromatin Structure of the HLA-DRA Gene

1989 • 13 citations

Upstream elements of the MHC class II E beta gene active in B cells.

1991 • 12 citations

Regulated progression of B lymphocyte differentiation from cultured fetal liver.

1987 • 11 citations

The effect of excess beta-chain synthesis on cell-surface expression of allele-mismatched class II heterodimers in vivo.

1990 • 11 citations

Functional consequences of overexpressed Ia antigens in AK alpha/AK beta transgenic mice.

1990 • 10 citations

Molecular genetics of class I genes in the mammalian major histocompatibility complex.

1986 • 10 citations

DNase I hypersensitive site flank the mouse class II major histocompatibility complex during B cell development

1991 • 8 citations

Evidence for chromatin structure as a regulatory determinant in HLA-DR ?gene expression

1985 • 6 citations

Non-consensus DNA sequences function in a cell-type-specific enhancer of the mouse class II MHC gene Aα

1991 • 5 citations

Existence of mixed isotype A beta E alpha class II molecules in Ed alpha gene-introduced C57BL/6 transgenic mice.

1990 • 5 citations

Quantitative analysis of integrated Ed alpha gene expression in C57BL/6 transgenic mice.

1988 • 4 citations

Control of transcription at the murine Aα locus

1990 • 3 citations