Mosaic expression of an Hprt transgene integrated in a region of Y heterochromatin

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

1961 • 3,881 citations

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

1990 • 1,630 citations

Genetic transformation of mouse embryos by microinjection of purified DNA.

1980 • 1,428 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules

1991 • 848 citations

The sex-determining region of the human Y chromosome encodes a finger protein

1987 • 847 citations

The Evolution of Sex Chromosomes

1991 • 789 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules

1991 • 673 citations

MAMMALIAN X-CHROMOSOME INACTIVATION

1983 • 635 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

1990 • 554 citations

Sensitive, high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated copies of EBV in a lymphoma line

1988 • 550 citations

Heterologous introns can enhance expression of transgenes in mice.

1991 • 489 citations

Types of visible variations induced by X-rays inDrosophila

1930 • 462 citations

Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.

1984 • 435 citations

Isolation of male embryonal carcinoma cells and their chromosome replication patterns

1982 • 422 citations

The Human Y Chromosome: Overlapping DNA Clones Spanning the Euchromatic Region

1992 • 394 citations

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1987 • 363 citations

Chromosomal position and activation of retroviral genomes inserted into the germ line of mice

1981 • 344 citations

A view of Interphase Chromosomes

1990 • 341 citations

Position effect variegation and chromatin proteins

1992 • 311 citations

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.

1983 • 299 citations

Position-effect variegation after 60 years

1990 • 286 citations

A sequence motif found in aDrosophilaheterochromatin protein is conserved in animals and plants

1991 • 273 citations

GENETIC CONTROL OF PRIMARY SEX DETERMINATION IN MICE

1986 • 253 citations

Transgenes as probes for active chromosomal domains in mouse development

1988 • 251 citations

Chromosomal position or virus mutation permits retrovirus expression in embryonal carcinoma cells

1986 • 236 citations

X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryo

1993 • 235 citations

HPRT: GENE STRUCTURE, EXPRESSION, AND MUTATION

1985 • 227 citations

MECHANISMS OF X-CHROMOSOME REGULATION

1988 • 222 citations

Isolation and Characterization of a Full-Length Expressible cDNA for Human Hypoxanthine Phosphoribosyltransferase

1983 • 222 citations

Age related reactivation of an X-linked gene

1987 • 220 citations

Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development

1989 • 211 citations

Non-random X-chromosome inactivation in mouse X-autosome translocation embryos—location of the inactivation centre

1983 • 208 citations

Position effect variegation in the mouse

1974 • 184 citations

Conversion of Normal Behavior to Shiverer by Myelin Basic Protein Antisense cDNA in Transgenic Mice

1988 • 182 citations

Heterochromatin: Molecular and Structural Aspects

1989 • 181 citations

Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal

1981 • 179 citations

The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: Evidence for an inversion of the Y chromosome during primate evolution

1988 • 177 citations

Transgenic mice containing intestinal fatty acid-binding protein-human growth hormone fusion genes exhibit correct regional and cell-specific expression of the reporter gene in their small intestine.

1988 • 174 citations

Fertility in mice requires X-Y pairing and a Y-chromosomal “Spermiogenesis” gene mapping to the long arm

1992 • 173 citations

Expression of the mouse HPRT gene: Deletional analysis of the promoter region of an X-Chromosome linked housekeeping gene

1986 • 160 citations

A structural basis for variegating position effects

1984 • 160 citations

Expression of a foreign gene in a line of transgenic mice is modulated by a chromosomal position effect.

1990 • 160 citations

Position effect variegation in Drosophila: Towards a genetics of chromatin assembly

1989 • 134 citations

A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1

1991 • 127 citations

The organization of the human HPRT gene

1986 • 124 citations

Molecular cloning and sequence analysis of a mouse Y chromosome RNA transcript expressed in the test is

1987 • 115 citations

Methylation of the mouse hprt gene differs on the active and inactive X chromosomes.

1986 • 105 citations

Duplication, Deletion, and Polymorphism in the Sex-Determining Region of the Mouse Y Chromosome

1989 • 103 citations

Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells.

1990 • 103 citations

Chromosome Structure: Euchromatin and Heterochromatin

1987 • 101 citations

Mammalian sex chromosomes: Evolution of organization and function

1991 • 99 citations

Position effect and related phenomena

1992 • 91 citations

Human hypoxanthine-guanine phosphoribosyltransferase. Evidence for tetrameric structure.

1978 • 88 citations

Cellular mosaicism in the methylation and expression of hemizygous loci in the mouse.

1989 • 84 citations

An increased level of sperm abnormalities in mice with a partial deletion of the Y chromosome

1991 • 83 citations

Asynchronous replication of homologous loci on human active and inactive X chromosomes.

1990 • 75 citations

Human and Mouse Hypoxanthine-Guanine Phosphoribosyltransferase: Dimers and Tetramers

1979 • 69 citations

Influence of partial deletion of the Y chromosome on mouse sperm phenotype

1991 • 65 citations

A repeated segment on the mouse Y chromosome is composed of retroviral-related, Y-enriched and Y-specific sequences.

1989 • 64 citations

Differential expression of α-fetoprotein genes on the inactive X chromosome in extraembryonic and somatic tissues of a transgenic mouse line

1986 • 63 citations

Sixty years of mystery.

1990 • 63 citations

A cytogenetic investigation of inherited true hermaphroditism in BALB/cWt mice

1980 • 61 citations

Primary and secondary nonrandom X chromosome inactivation in early female mouse embryos carrying Searle's translocation T(X; 16)16H

1980 • 61 citations

ISOLATION AND CHARACTERIZATION OF A MOUSE Y CHROMOSOMAL REPETITIVE SEQUENCE

1986 • 60 citations

Expression of human HPRT in the central nervous system of transgenic mice

1985 • 56 citations

Integration-specific retrovirus expression in embryonal carcinoma cells.

1984 • 53 citations

The peculiar genetic organization of Drosophila heterochromatin

1986 • 48 citations

A Chicken Transferrin Gene in Transgenic Mice Escapes X-Chromosome Inactivation

1987 • 46 citations

Clonal coat color variation due to a transforming gene expressed in melanocytes of transgenic mice.

1991 • 42 citations

Timing of Sex Chromosome Replication in Somatic and Germ-Line Cells of the Mouse and the Rat

1967 • 40 citations

Evolution of human Y-chromosome DNA

1982 • 38 citations

ELECTROPHORETIC VARIATION FOR X CHROMOSOME-LINKED HYPOXANTHINE PHOSPHORIBOSYL TRANSFERASE (HPRT) IN WILD-DERIVED MICE

1983 • 37 citations

Molecular characterization of a mouse Y chromosomal repetitive sequence that detects transcripts in the testis

1992 • 35 citations

Mammalian sex chromosomes: design or accident?

1992 • 34 citations

A cellular enhancer of retrovirus gene expression in embryonal carcinoma cells.

1987 • 29 citations

Timing of paternal Pgk-1 expression in embryos of transgenic mice

1991 • 27 citations

Mouse Y chromosome

1997 • 21 citations

The Y chromosome of the mouse is decondensed in Sertoli cells

1989 • 20 citations

An X-linked human collagen transgene escapes X inactivation in a subset of cells

1992 • 18 citations

X-inactivation of theStslocus in the mouse: an anomaly of the dosage compensation mechanism

1989 • 18 citations

Elevated levels of erythrocyte hypoxanthine phosphoribosyltransferase associated with allelic variation of murine Hprt

1985 • 15 citations

High resolution replication patterns of the human Y chromosome

1982 • 14 citations

Mouse Y Chromosome

1992 • 13 citations

Y chromosome replication and chromosome arrangement in germ line cells and sperm of the rat

1969 • 12 citations

Classification of Y chromosome polymorphisms by DNA content and C-banding

1989 • 10 citations

X chromosome-induced reversion of chromosome segregation in mouse/Chinese hamster somatic cell hybrids

1983 • 9 citations

Mouse Y chromosome

1993 • 4 citations

Variable evolutionary stability ofYchromosomal repeated sequences in the genusMus

1989 • 3 citations

Transgenic Mouse Carrying a Foreign Gene on Its Y-Chromosome

1988 • 3 citations