Coupling of Peripheral Tolerance to Endogenous Interleukin 10 Promotes Effective Modulation of Myelin-Activated T Cells and Ameliorates Experimental Allergic Encephalomyelitis

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Towards a network theory of the immune system.

1974 • 3,379 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Induction of tolerance by IL-10-treated dendritic cells.

1997 • 1,263 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

Methods in Immunology and Immunochemistry

1967 • 1,145 citations

Rheumatoid Arthritis

1996 • 960 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

1996 • 349 citations

Reversal of Proinflammatory Responses by Ligating the Macrophage Fcγ Receptor Type I

1998 • 330 citations

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity

1999 • 284 citations

High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice

2000 • 275 citations

Isolation of myelin basic protein-reactive T-cell lines from normal human blood

1983 • 270 citations

Regulatory T cells and inflammatory bowel disease

1999 • 270 citations

Local Delivery of Interleukin 4 by Retrovirus-Transduced T Lymphocytes Ameliorates Experimental Autoimmune Encephalomyelitis

1997 • 264 citations

Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

1993 • 260 citations

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

Amelioration of Autoimmune Encephalomyelitis by Myelin Basic Protein Synthetic Peptide-Induced Anergy

1992 • 251 citations

Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen.

1993 • 241 citations

Molecules involved in T-cell costimulation

1993 • 237 citations

Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies

1997 • 221 citations

Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants.

1992 • 219 citations

Multiple levels of peripheral tolerance

1993 • 216 citations

The third function of the thymus

2000 • 213 citations

Transgenic Interleukin 10 Prevents Induction of Experimental Autoimmune Encephalomyelitis

1999 • 203 citations

Treatment of Experimental Autoimmune Encephalomyelitis with Genetically Modified Memory T Cells

1997 • 180 citations

The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis

1998 • 171 citations

IL-10 fails to abrogate experimental autoimmune encephalomyelitis

1996 • 169 citations

Autoimmune Pathogenesis of Multiple Sclerosis: Role of Autoreactive T Lymphocytes and New Immunotherapeutic Strategies

1997 • 159 citations

Inhibition of Collagen-Induced Arthritis in Mice by Viral IL-10 Gene Transfer

1998 • 144 citations

A T Helper Cell 2 (Th2) Immune Response against Non-self Antigens Modifies the Cytokine Profile of Autoimmune T Cells and Protects against Experimental Allergic Encephalomyelitis

1997 • 136 citations

Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice.

1992 • 134 citations

The inability to process a self-peptide allows autoreactive T cells to escape tolerance.

1993 • 127 citations

Presentation of a Viral T Cell Epitope Expressed in the CDR3 Region of a Self Immunoglobulin Molecule

1993 • 123 citations

Studies of aggregated gamma-globulin. I. Sedimentation, electrophoretic and anticomplementary properties.

1960 • 119 citations

Molecular mechanisms underlying functional T-cell unresponsiveness

1995 • 115 citations

Regulation of Interleukin (IL)-12 Receptor β2 Subunit Expression by Endogenous IL-12: A Critical Step in the Differentiation of Pathogenic Autoreactive T Cells

1999 • 103 citations

Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein.

1996 • 87 citations

Systemic antigen in the treatment of T-cell-mediated autoimmune diseases

1997 • 85 citations

Activation of Regulatory Cells Suppresses Experimental Allergic Encephalomyelitis Via Secretion of IL-10

1999 • 73 citations

Immune complex‐induced interleukin‐6, interleukin‐10 and prostaglandin secretion by human monocytes: a network of pro‐ and anti‐inflammatory cytokines dependent on the antigen: antibody ratio

1996 • 68 citations

Immune complexes are potent inhibitors of interleukin‐12 secretion by human monocytes

1997 • 65 citations

Cross-linking of monocyte plasma membrane Fc alpha, Fc gamma or mannose receptors induces TNF production.

1993 • 62 citations

Induction of EAE in mice with recombinant human MOG, and treatment of EAE with a MOG peptide

1997 • 62 citations

T-cell tolerance

1993 • 55 citations

Studies of Aggregated γ-Globulin

1960 • 50 citations

Induction of tolerance to autoimmune diabetes with islet antigens.

1992 • 48 citations

Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus.

1993 • 44 citations

Neonatal Exposure to a Self-Peptide–Immunoglobulin Chimera Circumvents the Use of Adjuvant and Confers Resistance to Autoimmune Disease by a Novel Mechanism Involving Interleukin 4 Lymph Node Deviation and Interferon γ–mediated Splenic Anergy

1998 • 43 citations

Presentation of a T Cell Receptor Antagonist Peptide by Immunoglobulins Ablates Activation of T Cells by a Synthetic Peptide or Proteins Requiring Endocytic Processing

1997 • 42 citations

Experimental Autoimmune Encephalomyelitis Induced with a Combination of Myelin Basic Protein and Myelin Oligodendrocyte Glycoprotein Is Ameliorated by Administration of a Single Myelin Basic Protein Peptide

1998 • 39 citations

Thermal properties of human IgG

1987 • 39 citations

Specificity and T cell receptor β chain usage of a human collagen type II‐reactive T cell clone derived from a healthy individual

1992 • 37 citations

Tolerance of CD8+ T cells developing in parent-->F1 chimeras prepared with supralethal irradiation: step-wise induction of tolerance in the intrathymic and extrathymic environments.

1993 • 32 citations

Anergy of antigen-specific T lymphocytes is a potent mechanism of intravenously induced tolerance.

1994 • 29 citations

Infusion of soluble myelin basic protein protects long term against induction of experimental autoimmune encephalomyelitis

1997 • 11 citations

TCR Agonist and Antagonist Exert In Vivo Cross-Regulation When Presented on Igs

1998 • 9 citations

Differential Presentation of an Altered Peptide Within Fetal Central and Peripheral Organs Supports an Avidity Model for Thymic T Cell Development and Implies a Peripheral Readjustment for Activation

1999 • 7 citations