Anergy of antigen-specific T lymphocytes is a potent mechanism of intravenously induced tolerance.

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

1993 • 821 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Use of cationized ferritin as a label of negative charges on cell surfaces

1972 • 622 citations

Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice.

1991 • 499 citations

Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy.

1991 • 450 citations

Biological properties of interleukin 10

1992 • 359 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes.

1989 • 284 citations

Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin

1993 • 233 citations

CD4+ suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta.

1991 • 175 citations

Characterization of suppressor cells in anterior chamber-associated immune deviation (ACAID) induced by soluble antigen. Evidence of two functionally and phenotypically distinct T-suppressor cell populations.

1990 • 172 citations

The autocrine production of transforming growth factor-beta 1 during lymphocyte activation. A study with a monoclonal antibody-based ELISA.

1990 • 169 citations

Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-gamma-producing (Th1) cells.

1992 • 163 citations

IL-4 is required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride.

1991 • 156 citations

In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen.

1993 • 140 citations

Chemically modified antigen preferentially elicits induction of Th1-like cytokine synthesis patterns in vivo.

1993 • 98 citations

Identification of an immunosuppressive epitope of type II collagen that confers protection against collagen-induced arthritis.

1989 • 94 citations

The generation of a ‘tolerogen’ after the ingestion of ovalbumin is time-dependent and unrelated to serum levels of immunoreactive antigen

1990 • 94 citations

Antigen-induced and zymosan-induced arthritis in mice: studies on in vivo cartilage proteoglycan synthesis and chondrocyte death.

1981 • 92 citations

The induction of arthritis in mice by the cartilage proteoglycan aggrecan: Roles of CD4+ and CD8+ T cells

1992 • 91 citations

Interleukin (IL) 4 differentially regulates monocyte IL-1 family gene expression and synthesis in vitro and in vivo.

1993 • 91 citations

Anti-interferon gamma treatment blocks the ability of glutaraldehyde-polymerized allergens to inhibit specific IgE responses.

1991 • 89 citations

Anti-IL-4 diminishes in vivo priming for antigen-specific IL-4 production by T cells.

1993 • 64 citations

Collagen-induced arthritis in mice. Relationship of collagen-specific and total IgE synthesis to disease.

1991 • 59 citations

Detection and quantification of experimental joint inflammation in mice by measurement of99mTc-pertechnetate uptake

1981 • 56 citations

Antigen-specific inhibition of ongoing murine IgE responses. II. Inhibition of IgE responses induced by treatment with glutaraldehyde-modified allergens is paralleled by reciprocal increases in IgG2a synthesis.

1991 • 30 citations

Suppression of collagen-induced arthritis with pergastrically or intravenously administered type II collagen

1986 • 23 citations

Inhibition of a novel model of murine experimental autoimmune orchitis by intravenous administration with a soluble testicular antigen: Participation of CD8+ regulatory T cells

1992 • 22 citations

Suppression of hen egg lysozyme-induced arthritis by intravenous antigen administration: no role in this for antigen-driven bystander suppression

1994 • 4 citations