Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer.

1996 • 1,393 citations

Fc Receptors

1991 • 1,220 citations

Augmented humoral and anaphylactic responses in FcγRII-deficient mice

1996 • 828 citations

Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma

1994 • 747 citations

Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma

1994 • 647 citations

Defective Reticuloendothelial System Fc-Receptor Function in Systemic Lupus Erythematosus

1979 • 535 citations

Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

1996 • 476 citations

Cytoplasmic Domain Heterogeneity and Functions of IgG Fc Receptors in B Lymphocytes

1992 • 462 citations

Impaired IgG-Dependent Anaphylaxis and Arthus Reaction in FcγRIII (CD16) Deficient Mice

1996 • 452 citations

Treatment of Refractory Immune Thrombocytopenic Purpura with an Anti-Fcγ-Receptor Antibody

1986 • 363 citations

Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype

1989 • 356 citations

On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2.

1992 • 347 citations

Fc Receptors Initiate the Arthus Reaction: Redefining the Inflammatory Cascade

1994 • 329 citations

Infusion of Fcγ fragments for treatment of children with acute immune thrombocytopenic purpura

1993 • 326 citations

Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma RIIa.

1994 • 293 citations

Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function.

1992 • 288 citations

Cytotoxic antibodies trigger inflammation through Fc receptors

1995 • 263 citations

Skewed distribution of IGG FC receptor iia (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients

1995 • 213 citations

Neutrophils express the high affinity receptor for IgG (Fc gamma RI, CD64) after in vivo application of recombinant human granulocyte colony- stimulating factor

1991 • 212 citations

Intravenous anti-D treatment of immune thrombocytopenic purpura: analysis of efficacy, toxicity, and mechanism of effect [see comments]

1991 • 209 citations

Human immunoglobulin G (IgG) Fc receptor IIA (CD32) polymorphism and IgG2-mediated bacterial phagocytosis by neutrophils

1995 • 198 citations

Antigen targeting to myeloid-specific human Fc gamma RI/CD64 triggers enhanced antibody responses in transgenic mice.

1996 • 191 citations

Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils.

1989 • 185 citations

Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that overexpresses the proto-oncogene HER-2/neu.

1995 • 184 citations

A phase 1B trial of humanized monoclonal antibody M195 (anti-CD33) in myeloid leukemia: specific targeting without immunogenicity

1994 • 181 citations

Blockade of clearance of immune complexes by an anti-F(cγ) receptor monoclonal antibody

1986 • 164 citations

Phase I trial of 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and Fc gamma RIII.

1995 • 138 citations

Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner.

1995 • 127 citations

The blockade of Fc receptor-mediated clearance of immune complexes in vivo by a monoclonal antibody (2.4G2) directed against Fc receptors on murine leukocytes.

1984 • 117 citations

Influence of antibody isotype on passive serotherapy of lymphoma.

1985 • 112 citations

A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa.

1996 • 108 citations

Defective mononuclear phagocyte function in systemic lupus erythematosus: dissociation of Fc receptor-ligand binding and internalization.

1984 • 99 citations

HLA class II as potential target antigen on malignant B cells for therapy with bispecific antibodies in combination with granulocyte colony-stimulating factor

1996 • 94 citations

Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction.

1993 • 93 citations

Antibody-dependent enhancement of dengue virus infection mediated by bispecific antibodies against cell surface molecules other than Fc gamma receptors.

1991 • 93 citations

Human IgG Fc Receptors

1997 • 89 citations

A CD16/CD30 bispecific monoclonal antibody induces lysis of hodgkin's cells by unstimulated natural killer cells In AND In vivo

1993 • 87 citations

GP120 specific cellular cytotoxicity in HIV-1 seropositive individuals. Evidence for circulating CD16+ effector cells armed in vivo with cytophilic antibody.

1989 • 85 citations

Association of all three types of Fc gamma R (CD64, CD32, and CD16) with a gamma-chain homodimer in cultured human monocytes.

1993 • 74 citations

Functional differences between two Fc receptor ITAM signaling motifs

1995 • 71 citations

Construction and characterization of a humanized anti-gamma-Ig receptor type I (Fc gamma RI) monoclonal antibody.

1995 • 70 citations

F(c)gammaRI-targeted fusion proteins result in efficient presentation by human monocytes of antigenic and antagonist T cell epitopes.

1996 • 69 citations

A human tumor xenograft model of therapy with a bispecific monoclonal antibody targeting c-erbB-2 and CD16.

1993 • 68 citations

Monoclonal antibody 197 (anti‐FcγRI) infusion in a patient with immune thrombocytopenia purpura (ITP) results in down‐modulation of FcγRI on circulating monocytes

1996 • 55 citations

Autoantibodies directed against different classes of Fc gamma R are found in sera of autoimmune patients.

1993 • 53 citations

IgM anti-Fc gamma R autoantibodies trigger neutrophil degranulation.

1991 • 45 citations

G-CSF-Stimulated PMN in Immunotherapy of Breast Cancer with a Bispecific Antibody to FcγRI and to HER-2/neu (MDX-210)

1995 • 37 citations

Functions of the various IgG Fc receptors in mediating killing of Toxoplasma gondii.

1991 • 32 citations

Initial Trial of Bispecific Antibody-Mediated Immunotherapy of CD15-Bearing Tumors: Cytotoxicity of Human Tumor Cells Using a Bispecific Antibody Comprised of Anti-CD15 (MoAb PM81) and Anti-CD64/FcγRI (MoAb 32)

1992 • 30 citations

Inhibition of hepatic metastases of human colon cancer in nude mice by a chimeric SF-25 monoclonal antibody

1995 • 16 citations

Factors influencing antibody-mediated cytotoxicity during the immunotherapy of Rauscher-virus-induced myeloid leukemic cells

1989 • 4 citations

Bispecific Antibodies

2019 • 1 citations

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