Induction of tolerance to autoimmune diabetes with islet antigens.

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

1967 • 2,783 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product

1987 • 408 citations

Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance

1990 • 380 citations

Induction of Donor-Specific Unresponsiveness by Intrathymic Islet Transplantation

1990 • 377 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Self-Nonself Discrimination by T Cells

1990 • 331 citations

Studies of streptozotocin-induced insulitis and diabetes.

1977 • 262 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

A Method for Isolation of Islets of Langerhans from the Human Pancreas

1984 • 204 citations

Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells.

1989 • 198 citations

Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment

1988 • 197 citations

Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses.

1988 • 172 citations

Prevention of Autoimmune Diabetes in the BB Rat by Intrathymic Islet Transplantation at Birth

1992 • 141 citations

Prevention of Autoimmune Diabetes With Nonactivating Anti-CD3 Monoclonal Antibody

1992 • 132 citations

Treatment With Anti-T-Lymphocyte Antibodies Prevents Induction of Insulitis in Mice Given Multiple Doses of Streptozocin

1987 • 62 citations

Prevention of diabetes in BB/Wor rats by intrathymic islet injection.

1992 • 61 citations

Tissue-specific expression of allogeneic class II MHC molecules induces neither tissue rejection nor clonal inactivation of alloreactive T cells.

1990 • 56 citations

Immunologic Studies on the Induction of Diabetes in Experimental Animals: Cellular Basis for the Induction of Diabetes by Streptozotocin

1984 • 48 citations

Low-Dose Streptozocin-Induced Autoimmune Diabetes in Islet Transplantation Model

1991 • 46 citations

Ablation of ‘tolerance’ and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 34 citations