Molecules involved in T-cell costimulation

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Role of the CD28 receptor in T-cell activation

1990 • 684 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.

1992 • 375 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes.

1992 • 342 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells.

1991 • 335 citations

Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway

1991 • 325 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

Identification and distribution of the costimulatory receptor CD28 in the mouse.

1992 • 316 citations

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

1992 • 306 citations

B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas.

1982 • 297 citations

Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression

1992 • 285 citations

The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.

1992 • 273 citations

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.

1991 • 255 citations

Heat-stable antigen is a costimulatory molecule for CD4 T cell growth.

1992 • 254 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

Costimulation of T-cell growth

1992 • 225 citations

Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.

1992 • 220 citations

Multiple levels of peripheral tolerance

1993 • 216 citations

Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element

1991 • 194 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.

1992 • 153 citations

Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

1988 • 146 citations

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

1992 • 138 citations

Co‐stimulation of murine CD4 T cell growth: cooperation between B7 and heat‐stable antigen

1992 • 135 citations

The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells.

1992 • 125 citations

Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.

1992 • 118 citations

Costimulation of T cell receptor/CD3-mediated activation of resting human CD4+ T cells by leukocyte function-associated antigen-1 ligand intercellular cell adhesion molecule-1 involves prolonged inositol phospholipid hydrolysis and sustained increase of intracellular Ca2+ levels.

1992 • 106 citations

CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation.

1992 • 103 citations

Targeting autoantigen to B cells prevents the induction of a cell-mediated autoimmune disease in rats.

1992 • 94 citations

CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway.

1992 • 92 citations

Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn.

1992 • 89 citations

Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation.

1992 • 83 citations

Th1 cell anergy and blockade in G1a phase of the cell cycle.

1993 • 72 citations

Antigen presentation by resting B cells. Effectiveness at inducing T cell proliferation is determined by costimulatory signals, not T cell receptor occupancy.

1990 • 66 citations

Clonal anergy blocks the response to IL-4, as well as the production of IL-2, in dual-producing T helper cell clones.

1991 • 64 citations

Differential induction of transcription factors that regulate the interleukin 2 gene during anergy induction and restimulation.

1992 • 64 citations

Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones. Correlation with lymphokine secretion patterns.

1992 • 62 citations

Proliferation of human T lymphocytes induced with superantigens is not dependent on costimulation by the CD28 counter-receptor B7.

1993 • 58 citations

Costimulatory requirements of murine Th1 clones. The role of accessory cell-derived signals in responses to anti-CD3 antibody.

1990 • 56 citations

In vivo administration of interleukin‐2 turns on anergic self‐reactive T cells and leads to autoimmune disease

1992 • 44 citations

The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21

1992 • 34 citations

B cell presentation of a tolerogenic signal to Th clones

1992 • 25 citations

Probing martian space . . .

1989 • 4 citations