An integrated epigenetic and genetic approach to common human disease

Translating the Histone Code

2001 • 9,488 citations

Gene Silencing in Cancer in Association with Promoter Hypermethylation

2003 • 3,332 citations

Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

2002 • 3,174 citations

The history of cancer epigenetics

2004 • 2,270 citations

Hsp90 as a capacitor for morphological evolution

1998 • 2,261 citations

Homocysteine and Risk of Ischemic Heart Disease and Stroke

2002 • 2,000 citations

Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation

2003 • 1,970 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

Genetics of gene expression surveyed in maize, mouse and man

2003 • 1,518 citations

Genetic Dissection of Transcriptional Regulation in Budding Yeast

2002 • 1,389 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

1999 • 1,168 citations

Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period

2002 • 862 citations

Maternal Methyl Supplements in Mice Affect Epigenetic Variation and DNA Methylation of Offspring

2002 • 782 citations

Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk

2003 • 740 citations

Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors

2003 • 639 citations

Heritability of Type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance - a population-based twin study

1999 • 611 citations

Origin of a substantial fraction of human regulatory sequences from transposable elements

2003 • 575 citations

A Danish Twin Study of Manic-Depressive Disorders

1977 • 501 citations

Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age

1996 • 452 citations

Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia

2003 • 428 citations

Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution

2002 • 398 citations

Human disease genes

2001 • 383 citations

Retrotransposons as epigenetic mediators of phenotypic variation in mammals

2001 • 339 citations

The epigenetics of cancer etiology

2004 • 332 citations

Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome

2002 • 328 citations

Mouse models for neural tube closure defects

2000 • 285 citations

Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study

2003 • 269 citations

Epigenetics and the Environment

2003 • 260 citations

Human morbid genetics revisited: relevance of epigenetics

2001 • 254 citations

Age related reactivation of an X-linked gene

1987 • 220 citations

G<scp>ENETIC</scp>E<scp>FFECTS OF</scp>M<scp>ETHYLATION</scp>D<scp>IETS</scp>

2002 • 212 citations

Age-Associated Activation of Epigenetically Repressed Genes in the Mouse

2003 • 196 citations

Elevated Plasma Homocysteine Was Associated With Hemorrhagic and Ischemic Stroke, but Methylenetetrahydrofolate Reductase Gene C677T Polymorphism Was a Risk Factor for Thrombotic Stroke

2003 • 190 citations

Inheritance of allelic blueprints for methylation patterns

1988 • 172 citations

Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms Tumor

2001 • 171 citations

The history of cancer.

1926 • 169 citations

An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype

2003 • 158 citations

Epigenomics: Genome-Wide Study of Methylation Phenomena

2002 • 149 citations

Aberrant histone acetylation, altered transcription, and retinal degeneration in aDrosophilamodel of polyglutamine disease are rescued by CREB-binding protein

2003 • 138 citations

Epigenetic Variation and Human Disease

2002 • 126 citations

Transgenerational epigenetic inheritance

2003 • 119 citations

Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction

2002 • 110 citations

The prospective role of abnormal methyl metabolism in cadmium toxicity.

2002 • 101 citations

Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence and aging.

1993 • 100 citations

Familial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions

2003 • 99 citations

Genetic basis of neural tube defects. II. Genes correlated with folate and methionine metabolism.

2002 • 53 citations

Prevention of neural tube defects: vitamins, enzymes and genes

1998 • 42 citations

Epigenetics and human disease

1996 • 38 citations

X chromosome inactivation: theme and variations

2002 • 34 citations

Age-Related Changes in DNA Methylation: Do They Represent Continued Developmental Changes?

1989 • 33 citations

Age-related reactivation of an X-linked gene close to the inactivation centre in the mouse

1988 • 32 citations

An N-Ethyl-N-Nitrosourea Mutagenesis Screen for Epigenetic Mutations in the Mouse

2003 • 25 citations

Genetics, Individuality, and Medicine in the 21st Century**Previously presented at the annual meeting of The American Society of Human Genetics, in Los Angeles, on November 5, 2003.

2004 • 20 citations

Changes in frequency and localization of human X- and Y-chromatin bodies at interphase during in vitro cellular aging

1990 • 7 citations