Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2.

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

1999 • 5,748 citations

de la Chapelle, A.

1997 • 3,184 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

2000 • 1,706 citations

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

2000 • 1,493 citations

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

2002 • 1,231 citations

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.

1987 • 1,087 citations

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

2002 • 987 citations

Relaxation of imprinted genes in human cancer

1993 • 792 citations

Disruption of imprinting caused by deletion of the H19 gene region in mice

1995 • 765 citations

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour

1993 • 710 citations

CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease

2001 • 588 citations

Reduced genomic 5-methylcytosine content in human colonic neoplasia.

1988 • 491 citations

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

1994 • 466 citations

Loss of imprinting of a paternally expressed transcript, with antisense orientation to K _V LQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

1999 • 360 citations

Epigenetic lesions at the H19 locus in Wilms' tumour patients

1994 • 318 citations

Dependence of transcriptional repression on CpG methylation density.

1994 • 294 citations

Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability

1998 • 290 citations

Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19 -associated CTCF-binding sites in colorectal cancer

2000 • 228 citations

Activation of an imprinted allele of the insulin-like growth factor II gene implicated in rhabdomyosarcoma.

1994 • 218 citations

DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas.

1986 • 215 citations

Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers.

1995 • 208 citations

Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19

2000 • 203 citations

Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer

2001 • 196 citations

A Genome-Wide Screen for Normally Methylated Human CpG Islands That Can Identify Novel Imprinted Genes

2002 • 182 citations

Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms Tumor

2001 • 171 citations

Loss of imprinting in hepatoblastoma.

1995 • 146 citations

Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site.

2001 • 138 citations

Hot-stop PCR: a simple and general assay for linear quantitation of allele ratios

2000 • 106 citations

Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma

2001 • 98 citations

Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53

2000 • 97 citations

Frequent loss of imprinting of PEG1/MEST in invasive breast cancer.

1999 • 93 citations

Relaxation of IGF2 imprinting in Wilms tumours associated with specific changes in IGF2 methylation

1999 • 86 citations

The expression of the imprinted H19 and IGF‐2 genes in human bladder carcinoma

1995 • 86 citations

Frequent loss of imprinting of the H19 and IGF-II genes in ovarian tumors

1998 • 84 citations

Loss of Imprinting in Disease Progression in Chronic Myelogenous Leukemia

1998 • 82 citations

Genomic Deletion of an Imprint Maintenance Element Abolishes Imprinting of Both Insulin-like Growth Factor II andH19

1997 • 44 citations

Loss of Imprinting of Long QT Intronic Transcript 1 in Colorectal Cancer

2001 • 39 citations