Chromatin remodeling and human disease

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

2002 • 1,497 citations

MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin

1997 • 1,258 citations

Controlling the double helix

2003 • 1,102 citations

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

1999 • 1,068 citations

Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis

2000 • 994 citations

Three proteins define a class of human histone deacetylases related to yeast Hda1p

1999 • 744 citations

Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

1997 • 739 citations

Exit from G1 and S Phase of the Cell Cycle Is Regulated by Repressor Complexes Containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

2000 • 650 citations

Mutations truncating the EP300 acetylase in human cancers

2000 • 590 citations

Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

1998 • 568 citations

BRCA1 Is Associated with a Human SWI/SNF-Related Complex

2000 • 548 citations

Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure

2002 • 494 citations

Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation

2000 • 494 citations

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP

2000 • 424 citations

The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription

2002 • 405 citations

Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes

2002 • 331 citations

Histone acetylation and disease

2001 • 331 citations

Histone Acetyltransferase HBO1 Interacts with the ORC1 Subunit of the Human Initiator Protein

1999 • 315 citations

Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia

2002 • 309 citations

Requirement of RSF and FACT for Transcription of Chromatin Templates in Vitro

1998 • 298 citations

p300 gene alterations in colorectal and gastric carcinomas.

1996 • 293 citations

Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells

1993 • 292 citations

ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation

2000 • 271 citations

The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes

2000 • 262 citations

The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription

2002 • 228 citations

HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins

2000 • 217 citations

Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1arrest associated with induction of p16ink4a and activation of RB

2002 • 203 citations

Breastfeeding Effects on Intelligence Quotient in 4- and 11-Year-Old Children

1999 • 185 citations

SWI/SNF chromatin remodeling and cancer

2002 • 166 citations

Mammalian GCN5 and P/CAF Acetyltransferases Have Homologous Amino-Terminal Domains Important for Recognition of Nucleosomal Substrates

1998 • 162 citations

Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome

2001 • 162 citations

Amplification and over-expression of theAIB1 nuclear receptor co-activator gene in primary gastric cancers

2000 • 160 citations

Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association

2000 • 154 citations

Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression

2002 • 152 citations

Identification of a polymorphic, neuron-specific chromatin remodeling complex

2002 • 151 citations

Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development

2000 • 151 citations

A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage

2002 • 135 citations

The complexity of chromatin remodeling and its links to cancer

2002 • 124 citations

The TFIIIC90 Subunit of TFIIIC Interacts with Multiple Components of the RNA Polymerase III Machinery and Contains a Histone-Specific Acetyltransferase Activity

1999 • 113 citations

Compensation of BRG-1 Function by Brm

2002 • 108 citations

ATP-dependent chromatin remodeling activities

2001 • 100 citations

MECP2 truncating mutations cause histone H4 hyperacetylation in Rett syndrome

2001 • 77 citations

Requirement for TAF_II250 Acetyltransferase Activity in Cell Cycle Progression

2000 • 64 citations

Mechanisms of chromatin assembly and transcription

2002 • 60 citations

Capturing novel mouse genes encoding chromosomal and other nuclear proteins

1998 • 57 citations

Mammalian histone acetyltransferases and their complexes

2001 • 53 citations

MLL‐CBP fusion transcript in a therapy‐related acute myeloid leukemia with the t(11;16)(q23;p13) which developed in an acute lymphoblastic leukemia patient with Fanconi anemia

2000 • 27 citations

MLL-CBP fusion transcript in a therapy-related acute myeloid leukemia with the t(11;16)(q23;p13) which developed in an acute lymphoblastic leukemia patient with Fanconi anemia

2000 • 24 citations