Localisation of Nramp1 in macrophages: Modulation with activation and infection

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

ENDOCYTOSIS AND MOLECULAR SORTING

1996 • 1,537 citations

A new method of preparing gold probes for multiple-labeling cytochemistry.

1985 • 1,417 citations

Lack of Acidification inMycobacteriumPhagosomes Produced by Exclusion of the Vesicular Proton-ATPase

1994 • 1,289 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

1995 • 955 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

Functional macrophage cell lines transformed by abelson leukemia virus

1978 • 895 citations

Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.

1991 • 874 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

Fine Structure Immunocytochemistry

1993 • 707 citations

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus

1994 • 676 citations

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

1995 • 603 citations

Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome

1997 • 438 citations

Cytokine Activation Leads to Acidification and Increases Maturation of Mycobacterium avium-Containing Phagosomes in Murine Macrophages

1998 • 393 citations

Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis.

1996 • 357 citations

Nramp defines a family of membrane proteins.

1995 • 355 citations

A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.

1996 • 330 citations

Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores

1997 • 329 citations

A study of positive staining of ultrathin frozen sections

1978 • 329 citations

Acidification of phagosomes containing Salmonella typhimurium in murine macrophages

1996 • 312 citations

Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages.

1992 • 277 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane.

1996 • 258 citations

Possible pathways for lysosomal enzyme delivery.

1985 • 253 citations

Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicles.

1988 • 241 citations

Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.

1996 • 235 citations

Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles

1997 • 234 citations

Molecular Requirements for Bi-directional Movement of Phagosomes Along Microtubules

1997 • 232 citations

Macrophage activation: lipoarabinomannan from avirulent and virulent strains of Mycobacterium tuberculosis differentially induces the early genes c-fos, KC, JE, and tumor necrosis factor-alpha.

1993 • 216 citations

The unique trafficking pattern of Salmonella typhimurium-containing phagosomes in murine macrophages is independent of the mechanism of bacterial entry

1997 • 164 citations

Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells.

1991 • 164 citations

Phagocytosed Live Listeria monocytogenes Influences Rab5-regulated in Vitro Phagosome-Endosome Fusion

1996 • 149 citations

Nramp Transfection Transfers Ity/Lsh/Bcg-Related Pleiotropic Effects on Macrophage Activation: Influence on Oxidative Burst and Nitric Oxide Pathways

1995 • 133 citations

Membrane trafficking along the phagocytic pathway

1995 • 130 citations

Resistance to intracellular infections: comparative genomic analysis of Nramp

1996 • 128 citations

Implication of phagosome-lysosome fusion in restriction of Mycobacterium avium growth in bone marrow macrophages from genetically resistant mice

1993 • 112 citations

Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg)

1999 • 107 citations

Genomic Structure, Promoter Sequence, and Induction of Expression of the Mouse Nramp1 Gene in Macrophages

1995 • 107 citations

Differential expression of murine macrophage surface glycoprotein antigens in intracellular membranes

1987 • 98 citations

Gamma‐interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages

1995 • 93 citations

NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain.

1994 • 93 citations

Leishmania donovani-infected macrophages: characterization of the parasitophorous vacuole and potential role of this organelle in antigen presentation

1994 • 86 citations

Microtubule-associated Protein-dependent Binding of Phagosomes to Microtubules

1996 • 84 citations

Endosomal proteolysis of internalized proteins

1996 • 83 citations

The macrophage resistance gene Lsh/Ity/Bcg

1989 • 82 citations

Nramp1 locus encodes a 65 kDa interferon-γ-inducible protein in murine macrophages

1997 • 81 citations

Structural aspects of antibody-antigen interaction revealed through small random peptide libraries

1996 • 76 citations

Ectopic expression of Nramp1 in COS‐1 cells modulates iron accumulation

1998 • 69 citations

Genetic control of innate resistance to mycobacterial infections

1991 • 63 citations

Monoclonal antibodies that recognize distinct epitopes of the macrophage type three complement receptor differ in their ability to inhibit binding of Leishmania promastigotes harvested at different phases of their growth cycle.

1988 • 48 citations

Stabilized expression of mRNA is associated with mycobacterial resistance controlled by Nramp1

1997 • 42 citations

Membrane protein biosynthesis — all sewn up?

1997 • 35 citations

Analysis of Lsh Gene Expression in Congenic B10.L-Lsh’ Mice

1988 • 31 citations

Antibodies to rat liver cathepsins: characterization and use for the identification of enzyme precursors.

1986 • 19 citations

The discovery of the immunological function of the thymus

1991 • 16 citations

Location of NRAMP1 molecule on the plasma membrane and its association with microtubules

1996 • 16 citations