The Molecular Context of a Determinant Influences Its Dominant Expression in a T Cell Response Hierarchy Through “Fine Processing”

Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas.

1984 • 272 citations

Fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme in a genetically nonresponder mouse strain.

1979 • 192 citations

Constraints in T‐B cooperation related to epitope topology on E. coli β‐galactosidase. I. The fine specificity of T cells dictates the fine specificity of antibodies directed to conformation‐ dependent determinants

1985 • 97 citations

The Complexity of Structures Involved in T-Cell Activation

1983 • 83 citations

Distinct recognition phenotypes exist for T cell clones specific for small peptide regions of proteins. Implications for the mechanisms underlying major histocompatibility complex-restricted antigen recognition and clonal deletion models of immune response gene defects.

1985 • 74 citations

A limited region within hen egg-white lysozyme serves as the focus for a diversity of T cell clones.

1984 • 56 citations

Immunodominant protein epitopes I. Induction of suppression to hen egg white lysozyme is obliterated by removal of the first three N‐terminal amino acids

1984 • 55 citations

Ir gene defects may reflect a regulatory imbalance. I. Helper T cell activity revealed in a strain whose lack of response is controlled by suppression.

1979 • 54 citations

Ir Gene Defects May Reflect a Regulatory Imbalance

1979 • 37 citations

Selective reversal of H‐2‐linked genetic unresponsiveness to lysozymes: II. Alteration in the T helper/T suppressor balance, owing to gene(s) linked to Ir‐2, leads to responsiveness in BALB.B

1986 • 20 citations

Selective reversal of H-2 linked genetic unresponsiveness to lysozymes

1984 • 17 citations

The Design of Regulatory Circuitry: Predominant Idiotypy and the Idea of Regulatory Parsimony^a

1983 • 8 citations