Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal Acidification

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

The Crisis in Antibiotic Resistance

1992 • 2,815 citations

Intracellular pH.

1981 • 2,440 citations

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

Inactivation of Antibiotics and the Dissemination of Resistance Genes

1994 • 1,766 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

ENDOCYTOSIS AND MOLECULAR SORTING

1996 • 1,537 citations

Lack of Acidification inMycobacteriumPhagosomes Produced by Exclusion of the Vesicular Proton-ATPase

1994 • 1,289 citations

Endocytosis

1997 • 1,263 citations

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

1997 • 1,178 citations

pH and the recycling of transferrin during receptor-mediated endocytosis.

1983 • 1,165 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited.

1995 • 680 citations

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus

1994 • 676 citations

The respiratory burst oxidase.

1994 • 608 citations

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

1995 • 603 citations

Structure and function of vacuolar class of ATP-driven proton pumps

1989 • 600 citations

Segregation of transferrin to a mildly acidic (pH 6.5) para-golgi compartment in the recycling pathway

1984 • 586 citations

Arrest of Mycobacterial Phagosome Maturation Is Caused by a Block in Vesicle Fusion between Stages Controlled by rab5 and rab7

1997 • 556 citations

Identification of two lysosomal membrane glycoproteins.

1985 • 475 citations

Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome

1997 • 438 citations

The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH

1981 • 429 citations

Membrane fusion machinery: Insights from synaptic proteins

1993 • 380 citations

Friends and family: The role of the rab GTPases in vesicular traffic

1993 • 364 citations

Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis.

1996 • 357 citations

Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice.

1981 • 343 citations

A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.

1996 • 330 citations

The Mycobacterium tuberculosis phagosome interacts with early endosomes and is accessible to exogenously administered transferrin.

1996 • 307 citations

Identification and characterization of a second mouse Nramp gene

1995 • 289 citations

Susceptibility to Leprosy Is Linked to the HumanNRAMP1Gene

1998 • 266 citations

Haplotype Mapping and Sequence Analysis of the Mouse Nramp Gene Predict Susceptibility to Infection with Intracellular Parasites

1994 • 261 citations

Lysosomal Targeting of Palmitoyl-protein Thioesterase

1996 • 250 citations

Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.

1996 • 235 citations

A possible role for Na+,K+-ATPase in regulating ATP-dependent endosome acidification.

1989 • 229 citations

Regulation of endocytic pH by the Na+,K+-ATPase in living cells.

1989 • 228 citations

Tetanus toxin-mediated cleavage of cellubrevin impairs exocytosis of transferrin receptor-containing vesicles in CHO cells.

1994 • 227 citations

Phagosomal acidification is mediated by a vacuolar-type H(+)-ATPase in murine macrophages.

1990 • 217 citations

Managed care for viruses

1997 • 203 citations

Infectious Disease Surveillance: a Crumbling Foundation

1994 • 180 citations

Mycobacterium avium- and Mycobacterium tuberculosis-containing vacuoles are dynamic, fusion-competent vesicles that are accessible to glycosphingolipids from the host cell plasmalemma.

1996 • 178 citations

Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages

1997 • 170 citations

The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele

1996 • 163 citations

Regulation of Phagosomal Acidification

1997 • 156 citations

Infection Genomics:Nramp1as a Major Determinant of Natural Resistance to Intracellular Infections

1998 • 144 citations

Genetics and Resistance to Tuberculosis

1992 • 139 citations

Redistribution of intracellular Ca2+ stores during phagocytosis in human neutrophils

1994 • 136 citations

Genetic control of host resistance to infection

1994 • 133 citations

Phenotypic expression of genetically-controlled natural resistance to Mycobacterium bovis (BCG).

1984 • 128 citations

Intracellular fate of Mycobacterium avium: use of dual-label spectrofluorometry to investigate the influence of bacterial viability and opsonization on phagosomal pH and phagosome-lysosome interaction

1996 • 121 citations

Functional Complementation of the Yeast Divalent Cation Transporter Family SMF by NRAMP2, a Member of the Mammalian Natural Resistance-associated Macrophage Protein Family

1997 • 116 citations

Phagosome-lysosome fusion is a calcium-independent event in macrophages.

1996 • 115 citations

Differences in Response Among Inbred Mouse Strains to Infection with Small Doses of Mycobacterium bovis BCG

1981 • 114 citations

Implication of phagosome-lysosome fusion in restriction of Mycobacterium avium growth in bone marrow macrophages from genetically resistant mice

1993 • 112 citations

THE CHANGING FACE OF TUBERCULOSIS

1995 • 101 citations

Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils.

1991 • 92 citations

PROSPECTS FOR NEW INTERVENTIONS IN THE TREATMENT AND PREVENTION OF MYCOBACTERIAL DISEASE

1995 • 91 citations

Characterization of the amiloride-sensitive Na+-H+ antiport of human neutrophils

1986 • 89 citations

Synthesis of Some Cyclic Iodonium Salts

1956 • 89 citations

Characterization and subcellular localization of target membrane soluble NSF attachment protein receptors (t-SNAREs) in macrophages. Syntaxins 2, 3, and 4 are present on phagosomal membranes.

1996 • 84 citations

Immunogenetics in the analysis of resistance to intracellular pathogens

1995 • 75 citations

Regulation of host resistance toMycobacterium intracellulare in vivo and in vitro by theBcg gene

1989 • 69 citations

Reconstitution of Phagosome-Lysosome Fusion in StreptolysinO-permeabilized Cells

1997 • 69 citations

The role of macrophage activation and of Bcg-encoded macrophage function(s) in the control of Mycobacterium avium infection in mice

1990 • 64 citations

Killing of Mycobacterium smegmatis by Macrophages From Genetically Susceptible and Resistant Mice

1990 • 49 citations

Tuberculosis Control: the Relevance of Classic Principles in an Era of Acquired lmmunodeficiency Syndrome and Multidrug Resistance

1996 • 47 citations

Folimycin (Concanamycin A), an Inhibitor of V-Type H+-ATPase, Blocks Cell-Surface Expression of Virus-Envelope Glycoproteins

1993 • 41 citations

Zn2+ depletion blocks endosome fusion

1995 • 36 citations

Genetics of Leprosy

1991 • 29 citations

The vacuolar H(+)-ATPases: versatile proton pumps participating in constitutive and specialized functions of eukaryotic cells.

1993 • 24 citations

Frequencies of IFNγ- and IL-4-producing cells during Mycobacterium bovis BCG infection in two genetically susceptible mouse strains: role of αβ T cells and NK1.1 cells

1995 • 20 citations

A conserved glutamic acid bridge in serine carboxypeptidases, belonging to the α/β hydrolase fold, acts as a pH‐dependent protein‐stabilizing element

1994 • 9 citations