Interactions between Idd5.1/Ctla4 and Other Type 1 Diabetes Genes

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

2004 • 1,392 citations

Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes

2005 • 597 citations

Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus

2004 • 496 citations

Study on the prediction of visible absorption maxima of azobenzene compounds

2005 • 325 citations

PTPN22 Genetic Variation: Evidence for Multiple Variants Associated with Rheumatoid Arthritis

2005 • 230 citations

An Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells

2004 • 212 citations

Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes

2004 • 209 citations

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

2000 • 157 citations

Congenic Mapping of the Type 1 Diabetes Locus,Idd3, to a 780-kb Region of Mouse Chromosome 3: Identification of a Candidate Segment of Ancestral DNA by Haplotype Mapping

2000 • 140 citations

Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.

1997 • 129 citations

A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo

2005 • 127 citations

Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation.

1998 • 127 citations

In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes

2006 • 125 citations

A CD45 Polymorphism Associated with Multiple Sclerosis Disrupts an Exonic Splicing Silencer

2001 • 117 citations

Fine Mapping, Gene Content, Comparative Sequencing, and Expression Analyses Support Ctla4 and Nramp1 as Candidates for Idd5.1 and Idd5.2 in the Nonobese Diabetic Mouse

2004 • 111 citations

Linkage on Chromosome 3 of Autoimmune Diabetes and Defective Fc Receptor for IgG in NOD mice

1993 • 103 citations

The Association ofCTLA4Polymorphism with Type 1 Diabetes Is Concentrated in Patients Complicated with Autoimmune Thyroid Disease: A Multicenter Collaborative Study in Japan

2006 • 92 citations

Genetic Control of Autoimmunity: Protection from Diabetes, but Spontaneous Autoimmune Biliary Disease in a Nonobese Diabetic Congenic Strain

2004 • 89 citations

Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: Increased t allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease

2005 • 88 citations

Statistical Modeling of Interlocus Interactions in a Complex Disease: Rejection of the Multiplicative Model of Epistasis in Type 1 Diabetes

2001 • 81 citations

A Conserved Signal-Responsive Sequence Mediates Activation-Induced Alternative Splicing of CD45

2003 • 79 citations

B cell–deficient NOD.H-2h4 mice have CD4+CD25+ T regulatory cells that inhibit the development of spontaneous autoimmune thyroiditis

2006 • 74 citations

Single gene effects in mouse models of host: pathogen interactions

2005 • 73 citations

A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene

2007 • 71 citations

The Diabetes Susceptibility Locus Idd5.1 on Mouse Chromosome 1 Regulates ICOS Expression and Modulates Murine Experimental Autoimmune Encephalomyelitis

2004 • 62 citations

Differential Expression of CD45 Isoforms Is Controlled by the Combined Activity of Basal and Inducible Splicing-regulatory Elements in Each of the Variable Exons

2005 • 62 citations

Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes

2005 • 57 citations

Insulin Autoantibodies Are Associated With Islet Inflammation But Not Always Related to Diabetes Progression in NOD Congenic Mice

2003 • 52 citations

Further Mapping of the Idd5.1 Locus for Autoimmune Diabetes in NOD Mice

2001 • 43 citations

Localising Quantitative Trait Loci in the NOD Mouse Model of Type 1 Diabetes

1999 • 34 citations

Transgenic Expression of Helios in B Lineage Cells Alters B Cell Properties and Promotes Lymphomagenesis

2005 • 33 citations

Genome-Wide Microarray Expression Analysis of CD4+ T Cells from Nonobese Diabetic Congenic Mice Identifies Cd55 (Daf1) and Acadl as Candidate Genes for Type 1 Diabetes

2008 • 24 citations

Defective Induction of CTLA-4 in the NOD Mouse Is Controlled by the NOD Allele ofIdd3/IL-2and a Novel Locus (Ctex) Telomeric on Chromosome 1

2006 • 23 citations

Evidence for a Type 1 diabetes‐specific mechanism for the insulin gene‐associated IDDM2 locus rather than a general influence on autoimmunity

2004 • 21 citations

Genes and Genetics of Autoimmunity

1999 • 12 citations