A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries.

1996 • 3,063 citations

Matlnd and Matlnspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

1995 • 2,642 citations

Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver

2001 • 2,140 citations

Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen

1980 • 2,034 citations

A knowledge base for predicting protein localization sites in eukaryotic cells

1992 • 1,518 citations

A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

2000 • 1,413 citations

LEAP‐1, a novel highly disulfide‐bonded human peptide, exhibits antimicrobial activity

2000 • 1,313 citations

Survival and Causes of Death in Cirrhotic and in Noncirrhotic Patients with Primary Hemochromatosis

1985 • 1,069 citations

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

1999 • 1,068 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of Frataxin

1997 • 914 citations

Long-term survival in patients with hereditary hemochromatosis

1996 • 895 citations

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

1998 • 852 citations

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

1997 • 782 citations

The β-Thalassemias

1999 • 720 citations

Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis

1986 • 670 citations

Molecular Cloning of Transferrin Receptor 2

1999 • 638 citations

Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

1989 • 545 citations

Cellular and Subcellular Localization of the Nramp2 Iron Transporter in the Intestinal Brush Border and Regulation by Dietary Iron

1999 • 445 citations

Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis

1989 • 401 citations

PR39, a peptide regulator of angiogenesis

2000 • 383 citations

Liver cell models in in vitro toxicology.

1998 • 360 citations

Two established in vitro cell lines from human mesenchymal tumours

1967 • 331 citations

Liver pathology in genetic hemochromatosis: A review of 135 homozygous cases and their bioclinical correlations

1992 • 306 citations

MEASUREMENT OF LIVER-IRON CONCENTRATION IN NEEDLE-BIOPSY SPECIMENS

1971 • 295 citations

Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells.

1996 • 277 citations

Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C

1995 • 264 citations

A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes.

1988 • 239 citations

Transcriptional Regulation of β-Defensin Gene Expression in Tracheal Epithelial Cells

2000 • 205 citations

Primary liver cancer in genetic hemochromatosis: A clinical, pathological, and pathogenetic study of 54 cases

1993 • 191 citations

Mouse β-Defensin 3 Is an Inducible Antimicrobial Peptide Expressed in the Epithelia of Multiple Organs

1999 • 183 citations

Antimicrobial peptide defense in Drosophila

1997 • 180 citations

Direct evidence of the generation in human stomach of an antimicrobial peptide domain (lactoferricin) from ingested lactoferrin

1998 • 167 citations

Loops and Bulge/Loops in Iron-responsive Element Isoforms Influence Iron Regulatory Protein Binding

1998 • 144 citations

Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents.

1995 • 138 citations

Relationship between in vitro growth promotion and biophysical and biochemical properties of the serum supplement

1982 • 136 citations

Hepatic iron overload in patients with chronic viral hepatitis: Role of HFE gene mutations

1998 • 127 citations

Role of the Pre-S2 Domain of the Large Envelope Protein in Hepatitis B Virus Assembly and Infectivity

1998 • 127 citations

Liver fibrosis in genetic hemochromatosis

1992 • 125 citations

Transfusional iron overload: The relationship between tissue iron concentration and hepatic fibrosis in thalassaemia

1975 • 123 citations

Regulation of iron metabolism in HepG2 cells: A possible role for cytokines in the hepatic deposition of iron

1993 • 123 citations

Excess iron induces hepatic oxidative stress and transforming growth factor ?1 in genetic hemochromatosis

1997 • 120 citations

Long-term ursodeoxycholic acid therapy is associated with reduced risk of biliary pain and acute cholecystitis in patients with gallbladder stones: A cohort analysis

1999 • 113 citations

Interleukin-6 enhances hepatic transferrin uptake and ferritin expression in rats

1994 • 97 citations

Evidence of genetic transmission in African iron overload.

1998 • 90 citations

Interrelationships of alcohol and iron in liver disease with particular reference to the iron‐binding proteins, ferritin and transferrin

1999 • 87 citations

A simple and rapid procedure for preparation of large quantities of pure ovotransferrin

1967 • 72 citations

Liver gene expression during chronic dietary iron overload in rats

1990 • 71 citations

Expression of cytochromes P-450 in rat hepatoma cells. Analysis by monoclonal antibodies specific for cytochromes P-450 from rat liver induced by 3-methylcholanthrene or phenobarbital

1984 • 69 citations

Enhanced γ-Glutamyl Transpeptidase Expression and Selective Loss of CuZn Superoxide Dismutase in Hepatic Iron Overload

1998 • 68 citations

Excess iron into hepatocytes is required for activation of collagen type I gene during experimental siderosis

1994 • 65 citations

Kupffer cell depletion partially prevents hepatic heme oxygenase 1 messenger RNA accumulation in systemic inflammation in mice: Role of interleukin 1?

1998 • 58 citations

Rapid induction of hepatic fibrosis in the gerbil after the parenteral administration of iron-dextran complex

1991 • 57 citations

Proline-rich antimicrobial peptide, PR-39 gene transduction altered invasive activity and actin structure in human hepatocellular carcinoma cells

1999 • 56 citations

Adaptive Response of Iron Absorption to Anemia, Increased Erythropoiesis, Iron Deficiency, and Iron Loading in β2-Microglobulin Knockout Mice

1998 • 45 citations

Isolation and culture of Kupffer cells and hepatocytes from single rat livers: with observations on iron-loaded kupffer cells.

1981 • 41 citations

Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel

1994 • 41 citations

Carbonyl-iron supplementation induces hepatocyte nuclear changes in BALB/CJ male mice

1999 • 39 citations

Characterisation of citrate and iron citrate uptake by cultured rat hepatocytes

1998 • 37 citations

Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse

1995 • 36 citations

Hepatic stellate cells are not subjected to oxidant stress during iron-induced fibrogenesis in rodents

1998 • 35 citations

Inhibition of Iron/Ascorbate-Induced Lipid Peroxidation by an N-Terminal Peptide of Bovine Lactoferrin and Its Acylated Derivatives

1999 • 34 citations

Subtilisin-Like Proprotein Convertases, PACE4 and PC8, as Well as Furin, are Endogenous Proalbumin Convertases in HepG2 Cells

1999 • 31 citations

Macrophage-induced inhibition of nitric oxide production in primary rat hepatocyte cultures via prostaglandin E2 release

1998 • 31 citations

Iron Mobilisation and Cellular Protection by a New Synthetic Chelator O-Trensox

1998 • 31 citations

Iron and Infection

1996 • 24 citations

Evidence that an iron chelator regulates collagen synthesis by decreasing the stability of procollagen mRNA

1992 • 22 citations

Haemochromatosis and the liver.

1999 • 22 citations

Subcellular localization of the expressed 18 kDa FGF-2 isoform in corneal endothelial cells.

2000 • 20 citations

Electron microscopy of platelet interactions with heme-octapeptide-labeled fibrinogen

1990 • 20 citations

Complement C4 protein expression by rat hepatic stellate cells.

1996 • 18 citations

Murine Chromosomal Location of Five bHLH-Zip Transcription Factor Genes

1995 • 17 citations

Interaction of the Hemochromatosis Gene Product HFE with Transferrin Receptor Modulates Cellular Iron Metabolism

2009 • 16 citations

Iron and infection.

1987 • 5 citations

Culture Systems for Hepatocytes for Use in Toxicology and Differentiation Studies

1998 • 3 citations