Expression of cytochromes P-450 in rat hepatoma cells. Analysis by monoclonal antibodies specific for cytochromes P-450 from rat liver induced by 3-methylcholanthrene or phenobarbital

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

Multiplicity of mammalian microsomal cytochromes P-45.

1979 • 633 citations

An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1978 • 618 citations

Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms.

1975 • 456 citations

Chromosome tests with 134 compounds on Chinese hamster cells in vitro — A screening for chemical carcinogens

1977 • 445 citations

Characterization of differentiated and dedifferentiated clones from a rat hepatoma

1975 • 381 citations

Aryl hydrocarbon (benzo[a]pyrene) hydroxylase in microsomes from rat tissues: Differential inhibition and stimulation by benzoflavones and organic solvents

1971 • 374 citations

HEPATOMAS IN TISSUE CULTURE COMPARED WITH ADAPTING LIVER IN VIVO.

1964 • 314 citations

Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes

1982 • 265 citations

A Transplantable Bile-Secreting Hepatocellular Carcinoma in the Rat<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1961 • 248 citations

Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells.

1978 • 245 citations

Purification of cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydratase from a single preparation of rat liver microsomes

1980 • 228 citations

Isolation and purification of cytochrome P-450, and the existence of multiple forms

1979 • 210 citations

Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity.

1983 • 200 citations

DNA repair synthesis of cultured human cells as a rapid bioassay for chemical carcinogens

1975 • 176 citations

Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450.

1982 • 170 citations

Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones.

1982 • 160 citations

Purification and characterization of two constitutive forms of rat liver microsomal cytochrome P-450.

1982 • 156 citations

Multiple forms of cytochrome P-450 in phenobarbital- and 3-methylcholanthrene-treated rats. Separation and spectral properties.

1975 • 150 citations

Dedifferentiated variants of a rat hepatoma: Reversion analysis

1980 • 129 citations

Aldrin epoxidation, a highly sensitive indicator specific for cytochrome P-450-dependent mono-oxygenase activities.

1979 • 126 citations

Immunofluorescence analysis of the time-course of extinction, reexpression, and activation of albumin production in rat hepatoma-mouse fibroblast heterokaryons and hybrids.

1981 • 114 citations

Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Stimulation of "cytochrome P1-450-associated" enzyme activity by many inducing compounds.

1975 • 109 citations

Monoclonal antibodies to phenobarbital-induced rat liver cytochrome P-450

1984 • 108 citations

Dedifferentiated variants of a rat hepatoma: Analysis by cell hybridization

1979 • 106 citations

Selective Induction of Two Different Molecular Species of Cytochrome P-450 by Phenobarbital and 3-Methylcholanthrene

1981 • 95 citations

Regio- and stereoselectivity of various forms of purified cytochrome P -450 in the metabolism of benzo[ a ]pyrene and (-) trans -7,8-dihydroxy-7,8-dihydrobenzo[ a ]pyrene as shown by product formation and binding to DNA

1978 • 91 citations

Activation of xenobiotics by monooxygenases: cultures of mammalian cells as analytical tool

1977 • 85 citations

Position-specific oxygenation of benzo(a)pyrene by different forms of purified cytochrome P-450 from rabbit liver.

1975 • 69 citations

STUDIES ON THE MECHANISM OF ARYL HYDROCARBON HYDROXYLASE INDUCTION AND ITS ROLE IN CYTOTOXICITY AND TUMORIGENICITY

1971 • 62 citations

Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture—IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver

1973 • 62 citations

Metabolism of polycyclic hydrocarbons in mammalian cell cultures

1971 • 59 citations

Presence of cytochrome P-450- and cytochrome P-448-dependent monooxygenase functions in hepatoma cell lines

1980 • 54 citations

Aldrin Epoxidation Catalyzed by Purified Rat‐Liver Cytochromes P‐450 and P‐448 High Selectivity for Cytochrome P‐450

1980 • 52 citations

Mutagenicity of dimethylnitrosamine to mammalian cells as determined by the use of mouse liver microsomes

1975 • 49 citations

Comparison of different forms of liver, kidney, and lung microsomal cytochrome P-450 by immunological inhibition of regio- and stereoselective metabolism of warfarin.

1979 • 46 citations

Biochemical Basis of Chemical Carcinogenesis

1985 • 41 citations

Association and dissociation of the Ah locus with the metabolism of aflatoxin B1 by mouse liver. Co-segregation of aflatoxin B1 hydroxylase induction with aryl hydrocarbon (benzo(a)pyrene) hydroxylase induction.

1978 • 38 citations

Hydrocarbon-metabolizing activity of various mammalian cells in culture

1974 • 37 citations

Multiplicity of Cytochrome P-450 in Primary Fetal Hepatocytes in Culture

1981 • 31 citations

Identification of the cyanopregnenolone-inducible form of hepatic cytochrome P-450 as a catalyst of aldrin epoxidation

1983 • 30 citations

Differences in responses of 4 adult rat-liver epithelial cell lines to a spectrum of chemical mutagens

1984 • 30 citations

Immunological and enzymatic comparison of hepatic cytochrome P-450 fractions from phenobarbital-, 3-methylcholanthrene-, β-naphtoflavone- and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats

1983 • 27 citations

Monooxygenase and UDP-glucuronyltransferase activities in established cell cultures

1980 • 26 citations

Geno- and cytotoxicity of nitrosamines, aflatoxin B₁, and benzo[a]-pyrene in continuous cultures of rat hepatoma cells

1982 • 25 citations

In vitro interactions of di-, tetra- and hexa-chlorobiphenyl with rabbit liver monooxygenase

1977 • 24 citations

Mutagen-Metabolizing Enzymes in Mammalian Cell Cultures: Possibilities and Limitations for Mutagenicity Screening

1980 • 24 citations

Hydroxylation and sulfation of bile acids in rat hepatoma cultures under the influence of a glucocorticoid

1979 • 23 citations

Differential inducibility of chromosome aberrations and sister-chromatid exchanges by indirect mutagens in various mammalian cell lines

1981 • 20 citations

Enhancement of aflatoxin B1 cytotoxicity in differentiated rat hepatoma cultures by a prior glucocorticoid treatment of the monolayer

1979 • 19 citations

The capacity of rat hepatoma cell lines for O⁶-methylguanine-DNA repair correlates with their status of differentiation

1984 • 14 citations

No neoplastic alteration of metabolically competent rat liver cells in vitro by chemical carcinogens: 3-methylcholanthrene, dimethylnitrosamine and Natulan.

1978 • 5 citations

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