Role of the Pre-S2 Domain of the Large Envelope Protein in Hepatitis B Virus Assembly and Infectivity

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

1979 • 1,305 citations

Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.

1987 • 1,098 citations

Large surface proteins of hepatitis B virus containing the pre-s sequence

1984 • 812 citations

The role of envelope proteins in hepatitis B virus assembly.

1991 • 389 citations

Production of hepatitis B virus by a differentiated human hepatoma cell line after transfection with cloned circular HBV DNA

1986 • 350 citations

Hepatitis B virus infection of adult human hepatocytes cultured in the presence of dimethyl sulfoxide

1988 • 249 citations

Isolated and cultured hepatocytes

1986 • 222 citations

Post-translational alterations in transmembrane topology of the hepatitis B virus large envelope protein.

1994 • 202 citations

Myristylation of the Hepatitis B Virus Large Surface Protein Is Essential for Viral Infectivity

1995 • 187 citations

Novel transmembrane topology of the hepatitis B virus envelope proteins.

1995 • 184 citations

The preS1 protein of hepatitis B virus is acylated at its amino terminus with myristic acid

1987 • 169 citations

Reproducible High Level Infection of Cultured Adult Human Hepatocytes by Hepatitis B Virus: Effect of Polyethylene Glycol on Adsorption and Penetration

1993 • 163 citations

A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis.

1994 • 150 citations

Infectious Hepatitis B Virus Variant Defective in Pre-S2 Protein Expression in a Chronic Carrier

1993 • 139 citations

Hepadnavirus infection requires interaction between the viral pre-S domain and a specific hepatocellular receptor

1993 • 119 citations

Hepatitis B virus RNA element that facilitates accumulation of surface gene transcripts in the cytoplasm

1994 • 113 citations

Myristylation of the Large Surface Protein Is Required for Hepatitis B Virusin VitroInfectivity

1996 • 111 citations

Both Pre-S1 and S Domains of Hepatitis B Virus Envelope Proteins Interact with the Core Particle

1997 • 95 citations

Mapping a region of the large envelope protein required for hepatitis B virion maturation

1994 • 93 citations

Novel N-Terminal Amino Acid Sequence Required for Retention of a Hepatitis B Virus Glycoprotein in the Endoplasmic Reticulum

1989 • 82 citations

The N-terminal (pre-S2) domain of a hepatitis B virus surface glycoprotein is translocated across membranes by downstream signal sequences

1990 • 77 citations

The pre-S domain of the large viral envelope protein determines host range in avian hepatitis B viruses.

1995 • 71 citations

Hepatitis B virus (HBV) binding factor in human serum: candidate for a soluble form of hepatocyte HBV receptor

1993 • 46 citations

Long‐term productive episomal hepatitis B virus replication in primary cultures of adult human hepatocytes infected in vitro

1996 • 32 citations