Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel

Gene regulation by steroid hormones

1989 • 3,466 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics.

1986 • 1,091 citations

Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

1988 • 470 citations

The glucocorticoid receptor

1991 • 208 citations

Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.

1985 • 194 citations

RU 38486: A potent antiglucocorticoid in vitro and in vivo

1985 • 184 citations

Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism.

1984 • 182 citations

Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone.

1987 • 177 citations

Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16 alpha-carbonitrile regulate de novo synthesis of a common form of cytochrome P-450 in cultures of adult rat hepatocytes and in the liver in vivo.

1984 • 175 citations

Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response

1990 • 171 citations

Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro.

1993 • 167 citations

Influence of Extracellular Matrix Overlay on Phenobarbital-Mediated Induction of CYP2B1, 2B2, and 3A1 Genes in Primary Adult Rat Hepatocyte Culture

1993 • 140 citations

Daily variations in plasma noradrenaline, adrenaline and corticosterone concentrations in rats

1987 • 133 citations

Immunochemical evidence for induction of a common form of hepatic cytochrome P-450 in rats treated with pregnenolone-16 alpha-carbonitrile or other steroidal or non-steroidal agents.

1982 • 132 citations

Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo

1986 • 130 citations

Induction of the hepatic mixed-function oxidase system by synthetic glucocorticoids. Transcriptional and post-transcriptional regulation.

1987 • 128 citations

The effects of dexamethasone on in vitro collagen gene expression.

1987 • 128 citations

Isolation and characterization of the rat tyrosine aminotransferase gene.

1984 • 127 citations

Cytochrome P450 in livers of diabetic rats: Regulation by growth hormone and insulin

1989 • 113 citations

Regulation Of Gene Expression By Glucocorticoids

1989 • 110 citations

Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane.

1990 • 108 citations

Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA.

1986 • 92 citations

Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on matrigel.

1993 • 91 citations

Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species.

1983 • 85 citations

Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy

1988 • 76 citations

Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes.

1990 • 61 citations

Difference in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: phenobarbital-inducible P450IIB2 suppression by thyroid hormone acting directly, but not through the pituitary system.

1991 • 58 citations

Glucocorticoid regulation of a phenobarbital-inducible cytochrome P-450 gene: the presence of a functional glucocorticoid response element in the 5′-flanking region of the CYP2B2 gene

1990 • 54 citations

Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes.

1990 • 52 citations

Circadian rhythm of corticosterone in diabetic rats

1988 • 48 citations

Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids

1986 • 40 citations

Potentiation of 3-methylcholanthrene induction of rat hepatic cytochrome P450IA1 by dexamethasone in vivo.

1989 • 28 citations

RU486, a progestin antagonist, binds to progesterone receptors in a human endometrial cancer cell line and reverses the growth inhibition by progestins

1988 • 27 citations

Dexamethasone negatively regulates phenobarbitone-activated transcription but synergistically enhances cytoplasmic levels of cytochrome P-450b/e messenger RNA.

1990 • 21 citations

Selective induction of cytochrome P450e by kepone (chlordecone) in primary cultures of adult rat hepatocytes.

1991 • 19 citations