Tumor Cell Death Induced by Topoisomerase-Targeting Drugs

Ischemic Cell Death in Brain Neurons

1999 • 2,974 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA TOPOISOMERASES

1996 • 1,771 citations

Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein Family

1997 • 1,751 citations

Store depletion and calcium influx

1997 • 1,422 citations

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 896 citations

Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

1998 • 861 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3

2000 • 848 citations

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

1988 • 843 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

DNA Topoisomerases: Essential Enzymes and Lethal Targets

1994 • 722 citations

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

1999 • 708 citations

A Model for the Mechanism of Human Topoisomerase I

1998 • 686 citations

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

1984 • 559 citations

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1998 • 537 citations

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

1989 • 533 citations

DNA topoisomerase-targeting antitumor drugs can be studied in yeast.

1988 • 490 citations

Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells.

1991 • 450 citations

The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance

1999 • 443 citations

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.

1990 • 427 citations

Secondary leukemias induced by topoisomerase-targeted drugs

1998 • 414 citations

Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia

2000 • 394 citations

Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.

1991 • 392 citations

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

1988 • 391 citations

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases

2000 • 358 citations

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

1999 • 340 citations

Antitumor bisdioxopiperazines inhibit yeast DNAtopoisomerase II by trapping the enzyme in the form of a closed proteinclamp.

1994 • 339 citations

DNA Topoisomerase IIβ and Neural Development

2000 • 338 citations

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1972 • 315 citations

The Bloom's Syndrome Gene Product Interacts with Topoisomerase III

2000 • 313 citations

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity.

1996 • 301 citations

The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin.

1994 • 300 citations

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1987 • 291 citations

Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

1988 • 282 citations

DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors.

1993 • 265 citations

cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment.

1988 • 260 citations

Ubiquitin-dependent Destruction of Topoisomerase I Is Stimulated by the Antitumor Drug Camptothecin

1997 • 259 citations

The Werner Syndrome Gene Product Co-purifies with the DNA Replication Complex and Interacts with PCNA and Topoisomerase I

1999 • 249 citations

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells.

1988 • 244 citations

Isolation of cDNA clones encoding the β isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24

1992 • 237 citations

CAR1, a TNFR–Related Protein, Is a Cellular Receptor for Cytopathic Avian Leukosis–Sarcoma Viruses and Mediates Apoptosis

1996 • 236 citations

DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA.

1989 • 219 citations

Extracellular Acidification Induces Human Neutrophil Activation

1999 • 218 citations

beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin.

1993 • 212 citations

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

1999 • 211 citations

The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B.

1992 • 209 citations

SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

2000 • 208 citations

Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system.

1993 • 207 citations

Effects of Uracil Incorporation, DNA Mismatches, and Abasic Sites on Cleavage and Religation Activities of Mammalian Topoisomerase I

1997 • 199 citations

RecQ Helicase and Topoisomerase III Comprise a Novel DNA Strand Passage Function

1999 • 196 citations

An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis

1999 • 192 citations

Hypersensitivity ofKu80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development

1997 • 183 citations

DNA Cleavage within the MLL Breakpoint Cluster Region Is a Specific Event Which Occurs as Part of Higher-Order Chromatin Fragmentation during the Initial Stages of Apoptosis

1997 • 182 citations

Topoisomerase I inhibitors: selectivity and cellular resistance

1999 • 177 citations

Induction of Reversible Complexes between Eukaryotic DNA Topoisomerase I and DNA-containing Oxidative Base Damages

1999 • 176 citations

Targeted Disruption of the Mouse Topoisomerase I Gene by Camptothecin Selection

1996 • 175 citations

Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives

1992 • 174 citations

The Domain Organization of Human Topoisomerase I

1996 • 173 citations

Trapping of Mammalian Topoisomerase I and Recombinations Induced by Damaged DNA Containing Nicks or Gaps

1997 • 169 citations

Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors

1993 • 169 citations

Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro.

1988 • 168 citations

Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II.

1993 • 167 citations

Treatment of malignant melanoma with camptothecin (NSC-100880).

1972 • 158 citations

Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen.

1995 • 157 citations

Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events.

1994 • 157 citations

Processing of topoisomerase I cleavable complexes into DNA damage by transcription

1997 • 156 citations

Mammalian DNA topoisomerase IIIα is essential in early embryogenesis

1998 • 155 citations

NF-κB Activation by Camptothecin

2000 • 153 citations

New technique for uncoupling the cleavage and religation reactions of Eukaryotic Topoisomerase I.

1991 • 153 citations

Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene

1987 • 150 citations

Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones.

1997 • 149 citations

Studies on camptothecin. I. Effects of nucleic acid and protein synthesis.

1971 • 146 citations

DNA topoisomerase I is essential in Drosophila melanogaster.

1993 • 144 citations

Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA.

1996 • 143 citations

Multiple roles of Spo11 in meiotic chromosome behavior

2000 • 142 citations

SUMO-1 Conjugation to Human DNA Topoisomerase II Isozymes

2000 • 142 citations

Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta

2000 • 141 citations

Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.

1995 • 138 citations

Localization of specific topoisomerase I interactions within the transcribed region of active heat shock genes by using the inhibitor camptothecin.

1987 • 137 citations

Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription

1990 • 133 citations

Human TOP3: a single-copy gene encoding DNA topoisomerase III.

1996 • 125 citations

Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate

1989 • 124 citations

Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells

1996 • 123 citations

Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI anticancer drug screen: Multifactorial relationships with topoisomerase i, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways

1999 • 123 citations

Identification of a Nucleolin Binding Site in Human Topoisomerase I

1996 • 121 citations

Mitotic chromosome condensation in the rDNA requires TRF4 and DNA topoisomerase I in Saccharomyces cerevisiae.

1996 • 119 citations

Induction of topoisomerase I cleavage complexes by 1-β- <scp>d</scp> -arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells

2000 • 108 citations

The specific interactions of HMG 1 and 2 with negatively supercoiled DNA are modulated by their acidic C-terminal domains and involve cysteine residues in their HMG 1/2 boxes

1993 • 107 citations

Minor Groove-Directed and Intercalative Ligand−DNA Interactions in the Poisoning of Human DNA Topoisomerase I by Protoberberine Analogs

1997 • 107 citations

Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.

1999 • 106 citations

Meiosis-specific formation of joint DNA molecules containing sequences from homologous chromosomes

1994 • 106 citations

Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site.

1990 • 98 citations

Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions

2000 • 97 citations

Camptothecin induction of a time- and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity.

1995 • 96 citations

Effects of camptothecin on RNA synthesis in leukemia L1210 cells

1971 • 94 citations

Murine Transgenic Cells Lacking DNA Topoisomerase IIβ Are Resistant to Acridines and Mitoxantrone: Analysis of Cytotoxicity and Cleavable Complex Formation

1999 • 94 citations

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.

1988 • 93 citations

The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53

1999 • 93 citations

Simian Virus 40 Large T Antigen Binds to Topoisomerase I

1996 • 91 citations

Human Topoisomerase I Poisoning by Protoberberines: Potential Roles for Both Drug−DNA and Drug−Enzyme Interactions

2000 • 87 citations

Camptothecin effects on DNA synthesis in murine leukemia cells

1972 • 87 citations

Maternal diet and infant leukemia: A role for DNA topoisomerase II inhibitors?

1998 • 84 citations

Ribosome Formation is Blocked by Camptothecin, a Reversible Inhibitor of RNA Synthesis

1971 • 83 citations

Mechanism-Based Chemopreventive Strategies Against Etoposide-Induced Acute Myeloid Leukemia: Free Radical/Antioxidant Approach

1999 • 83 citations

The topoisomerase I poison camptothecin generates a Chk1‐dependent DNA damage checkpoint signal in fission yeast

1999 • 74 citations

DNA topoisomerase II is the molecular target of bisdioxopiperazine derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiae.

1995 • 72 citations

Hotspot sites for acridine-induced frameshift mutations in bacteriophage T4 correspond to sites of action of the T4 type II topoisomerase

1988 • 68 citations

Eukaryotic topoisomerase I-DNA interaction is stabilized by helix curvature

1991 • 68 citations

Inhibition of eukaryotic DNA topoisomerase I and II activities by indoloquinolinedione derivatives.

1991 • 64 citations

Acute Myelogenous Leukemia After Treatment for Malignant Germ Cell Tumors in Children

1999 • 64 citations

Benzo[ a ]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages

2000 • 63 citations

DNA Damage Signals Induction of Fas Ligand in Tumor Cells

1999 • 62 citations

Potent topoisomerase I inhibition by novel silatecans eliminates glioma proliferation in vitro and in vivo.

1999 • 61 citations

Spontaneous DNA Damage Stimulates Topoisomerase II-mediated DNA Cleavage

1997 • 59 citations

The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast

1999 • 58 citations

Essential functions of DNA topoisomerase I in Drosophila melanogaster

2000 • 56 citations

Mutations of Human Topoisomerase IIα Affecting Multidrug Resistance and Sensitivity

1999 • 56 citations

Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA.

1993 • 56 citations

Selective use of an alternative stop codon and polyadenylation signal within intron sequences leads to a truncated topoisomerase II alpha messenger RNA and protein in human HL-60 leukemia cells selected for resistance to mitoxantrone.

1995 • 52 citations

DNA topoisomerase II expression, stability, and phosphorylation in two VM-26-resistant human leukemic CEM sublines.

1995 • 52 citations

Interactions between DNA Helicases and Frozen Topoisomerase IV-Quinolone-DNA Ternary Complexes

1999 • 48 citations

Cloning of cDNA Encoding a Novel Mouse DNA Topoisomerase III (Topo IIIβ) Possessing Negatively Supercoiled DNA Relaxing Activity, Whose Message Is Highly Expressed in the Testis

1998 • 48 citations

A new human topoisomerase III that interacts with SGS1 protein

1999 • 47 citations

Cloning and Characterization of DrosophilaTopoisomerase IIIβ

2000 • 46 citations

Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions.

2000 • 44 citations

Induction of Topoisomerase I Cleavage Complexes by the Vinyl Chloride Adduct 1,N 6-Ethenoadenine

1998 • 42 citations

Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen

1998 • 39 citations

Differential Poisoning of Topoisomerases by Menogaril and Nogalamycin Dictated by the Minor Groove-Binding Nogalose Sugar

1997 • 38 citations

P53 Status, DNA Double-strand Break Repair Proficiency, and Radiation Response of Mouse Lymphoid and Myeloid Cell Lines

1994 • 37 citations

A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: A potential mechanism for topoisomerase I poisoning

1997 • 37 citations

Human DNA topoisomerase I-mediated cleavage and recombination of duck hepatitis B virus DNA in vitro

1999 • 35 citations

DNA Abasic Lesions in a Different Light: Solution Structure of an Endogenous Topoisomerase II Poison

1999 • 35 citations

Topoisomerase II-mediated DNA Cleavage and Religation in the Absence of Base Pairing

1998 • 34 citations

Complex response of breast epithelial cell lines to topoisomerase inhibitors.

1998 • 34 citations

Cytosine Arabinoside Lesions Are Position-specific Topoisomerase II Poisons and Stimulate DNA Cleavage Mediated by the Human Type II Enzymes

1999 • 33 citations

Topoisomerase I Associates Specifically with Simian Virus 40 Large-T-Antigen Double Hexamer–Origin Complexes

2000 • 32 citations

Topoisomerase II Site-directed Alkylation of DNA by Psorospermin and Its Effect on Topoisomerase II-mediated DNA Cleavage

1998 • 30 citations

DNA Minor Groove Binding-Directed Poisoning of Human DNA Topoisomerase I by Terbenzimidazoles

1998 • 29 citations

Detection of Apoptosis Induced by Topoisomerase Inhibitors and Serum Deprivation in Syrian Hamster Embryo Cells

2000 • 29 citations

Involvement of intracellular ATP in cytotoxicity of topoisomerase II-targetting antitumor drugs.

1987 • 29 citations

BARRETT'S ESOPHAGUS

1999 • 28 citations

Topoisomerase I-targeting drugs

1998 • 26 citations

DNA Topoisomerase-Mediated Illegitimate Recombination

1994 • 26 citations

Integration of simian virus 40 into cellular DNA occurs at or near topoisomerase II cleavage hot spots induced by VM-26 (teniposide).

1993 • 24 citations

Altered DNA topoisomerase II in multidrug resistance

1993 • 21 citations

Site-Specific Topoisomerase I-Mediated DNA Cleavage Induced by Nogalamycin: A Potential Role of Ligand-Induced DNA Bending at a Distal Site

2000 • 21 citations

Plasmid linking number change induced by topoisomerase I-mediated DNA damage

1999 • 18 citations

Are topoisomerase II inhibitor-induced micronuclei in vitro a predictive marker for the compounds' ability to cause secondary leukemias after treatment?

1999 • 17 citations

Illegitimate recombination induced by benzo[a]pyrene diol epoxide in Escherichia coli.

1988 • 17 citations

DNA nick processing by exonuclease and polymerase activities of bacteriophage T4 DNA polymerase accounts for acridine-induced mutation specificities in T4.

1995 • 16 citations

A role for the amino terminus of human topoisomerase I

1998 • 14 citations

P53 status plays no role in radiosensitizing effects of SN-38, a camptothecin derivative

2000 • 9 citations