Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.

1987 • 2,266 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

ISCN 1995 An international system for human cytogenetic nomenclature

1995 • 1,900 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

1988 • 843 citations

Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization

1981 • 836 citations

Type II DNA topoisomerases: Enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break

1980 • 547 citations

DNA topoisomerase-targeting antitumor drugs can be studied in yeast.

1988 • 490 citations

Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA

1987 • 426 citations

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

1988 • 391 citations

Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.

1987 • 345 citations

Inhibitors of DNA topoisomerases

1988 • 340 citations

DNA Topoisomerases: Enzymes That Control DNA Conformation

1985 • 337 citations

An Activity from Mammalian Cells That Untwists Superhelical DNA—A Possible Swivel For DNA Replication

1972 • 332 citations

Recent studies of DNA topoisomerases

1987 • 323 citations

Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro.

1987 • 293 citations

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1987 • 291 citations

cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment.

1988 • 260 citations

Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks.

1988 • 214 citations

DNA topoisomerases as targets for cancer therapy

1985 • 197 citations

Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene.

1985 • 193 citations

Identification of a vaccinia virus gene encoding a type I DNA topoisomerase.

1987 • 148 citations

Topoisomerase Inhibitors Can Selectively Interfere with Different Stages of Simian Virus 40 DNA Replication

1986 • 135 citations

The nucleotide sequence of the fission yeast DNA topoisomerase II gene: structural and functional relationships to other DNA topoisomerases.

1986 • 119 citations

Complete nucleotide sequence of the topA gene encoding Escherichia coli DNA topoisomerase I

1986 • 94 citations

Characterization of a camptothecin-resistant human DNA topoisomerase I.

1988 • 82 citations

Topoisomerase inhibitors can selectively interfere with different stages of simian virus 40 DNA replication.

1986 • 80 citations

Nucleic Acids and Molecular Biology

1987 • 79 citations

Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli.

1987 • 66 citations

The gene encoding the T-cell surface protein T4 is located on human chromosome 12.

1986 • 62 citations

Camptothecin, A Specific Inhibitor of Type I DNA Topoisomerase, Induces DNA Breakage at Replication Forks

1988 • 59 citations

Intercalator-induced, toposiomerase II-mediated DNA cleavage and its modification by antineoplastic antimetabolites

1986 • 21 citations