Cytosine Arabinoside Lesions Are Position-specific Topoisomerase II Poisons and Stimulate DNA Cleavage Mediated by the Human Type II Enzymes

DNA TOPOISOMERASES

1996 • 1,771 citations

Cleavage of DNA by mammalian DNA topoisomerase II.

1983 • 539 citations

Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme

1998 • 498 citations

Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells.

1991 • 450 citations

Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle.

1988 • 415 citations

Correlation of cytotoxicity with incorporation of ara-C into DNA.

1980 • 362 citations

Ara-C: Cellular and Molecular Pharmacology

1997 • 266 citations

Eukaryotic DNA topoisomerase IIβ

1998 • 233 citations

When good enzymes go bad: Conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

1993 • 203 citations

Lethality of human myeloblasts correlates with the incorporation of arabinofuranosylcytosine into DNA.

1981 • 203 citations

Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-beta-D-arabinofuranosylcytosine.

1991 • 198 citations

Transport and metabolism of deoxycytidine and 1-beta-D-arabinofuranosylcytosine into cultured Novikoff rat hepatoma cells, relationship to phosphorylation, and regulation of triphosphate synthesis.

1978 • 197 citations

Physiological regulation of eukaryotic topoisomerase II

1998 • 188 citations

The abasic site as a challenge to DNA polymerase

1990 • 168 citations

Effect of ara-C incorporation on deoxyribonucleic acid synthesis in cells

1982 • 141 citations

Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form

1987 • 134 citations

Spontaneous DNA Lesions Poison Human Topoisomerase IIα and Stimulate Cleavage Proximal to Leukemic 11q23 Chromosomal Breakpoints

1997 • 119 citations

Functional consequences of the arabinosylcytosine structural lesion in DNA

1988 • 112 citations

Effects of 1-beta-D-arabinofuranosylcytosine incorporation on elongation of specific DNA sequences by DNA polymerase beta.

1988 • 108 citations

Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites.

1995 • 107 citations

Abasic Sites Stimulate Double-stranded DNA Cleavage Mediated by Topoisomerase II

1995 • 105 citations

Effects of 1-beta-D-arabinofuranosylcytosine incorporation on eukaryotic DNA template function.

1984 • 104 citations

Apurinic Sites Are Position-specific Topoisomerase II Poisons

1997 • 99 citations

An abasic site in DNA. Solution conformation determined by proton NMR and molecular mechanics calculations

1987 • 96 citations

NMR studies of abasic sites in DNA duplexes: deoxyadenosine stacks into the helix opposite the cyclic analog of 2-deoxyribose

1988 • 86 citations

Biochemical and cellular pharmacology of cytosine arabinoside.

1985 • 85 citations

Response of L1210 to combinations of cytosine arabinoside and VM-26 or VP16-213

1975 • 85 citations

The response of eukaryotic topoisomerases to DNA damage

1998 • 84 citations

Inhibition of DNA polymerase-α and -β of calf thymus by 1-β-d-arabinofuranosylcytosine-5′-triphosphate

1977 • 84 citations

Refined Solution Structure of a DNA Heteroduplex Containing an Aldehydic Abasic Site

1995 • 80 citations

Sequence-specific effects of ara-5-aza-CTP and ara-CTP on DNA synthesis by purified human DNA polymerases in vitro: visualization of chain elongation on a defined template.

1987 • 75 citations

Structures of Apurinic and Apyrimidinic Sites in Duplex DNAs

1998 • 64 citations

Solution Conformation of an Abasic DNA Undecamer Duplex d(CGCACXCACGC)·d(GCGTGTGTGCG): The Unpaired Thymine Stacks Inside the Helix

1997 • 63 citations

NMR studies of abasic sites in DNA duplexes: deoxyadenosine stacks into the helix opposite acyclic lesions

1989 • 59 citations

Spontaneous DNA Damage Stimulates Topoisomerase II-mediated DNA Cleavage

1997 • 59 citations

Solution Structure of a DNA Dodecamer Containing the Anti-Neoplastic Agent Arabinosylcytosine: Combined Use of NMR, Restrained Molecular Dynamics, and Full Relaxation Matrix Refinement

1994 • 52 citations

Cell-cycle-dependent phosphorylation and activity of Chinese-hamster ovary topoisomerase II

1993 • 48 citations

Aberrant double replication of segments of chromosomal DNA following DNA synthesis inhibition by cytosine arabinoside

1979 • 44 citations

Incorporation of cytosine arabinoside monophosphate into DNA at internucleotide linkages by human DNA polymerase alpha

1992 • 44 citations

Evidence for a new mechanism of cytotoxicity of 1-beta-D arabinofuranosylcytosine.

1979 • 42 citations

Molecular structure of a DNA decamer containing an anticancer nucleoside arabinosylcytosine: conformational perturbation by arabinosylcytosine in B-DNA

1991 • 41 citations

The Effects of Cytosine Arabinoside on RNA-primed DNA Synthesis by DNA Polymerase α-Primase

1995 • 39 citations

The distribution of immunoreactive topoisomerase II Protein in human tissues and neoplasms.

1992 • 34 citations

Position-Specific Effects of Base Mismatch on Mammalian Topoisomerase II DNA Cleaving Activity

1996 • 34 citations

Topoisomerase II-mediated DNA Cleavage and Religation in the Absence of Base Pairing

1998 • 34 citations

Mechanism of 1- -D-arabinofuranosylcytosine-induced cell lethality.

1972 • 31 citations

The effect of 1-beta-D-arabinofuranosylcytosine on cell viability, DNA synthesis, and chromatid breakage in synchronized hamster fibrosarcoma cells.

1976 • 31 citations

Mechanism of DNA synthesis inhibition by arabinosyl cytosine and arabinosyl adenine

1976 • 31 citations

Effect of 1-β-D-arabinofuranosylcytosine (ara-C) on nuclear topoisomerase II activity and on the DNA cleavage and cytotoxicity produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) and etoposide in m-AMSA-sensitive and -resistant human leukemia cells

1987 • 24 citations

High-dose cytosine arabinoside and etoposide: an effective regimen without anthracyclines for refractory childhood acute non-lymphocytic leukemia

1997 • 21 citations

Synthesis and Proton-NMR Studies of Oligonucleotides Containing an Apurinic (AP) Site

1987 • 19 citations

Cytosine arabinoside toxicity: molecular events, biological consequences, and their implications.

1987 • 19 citations

Accumulation of leukemic cell DNA strand breaks with adriamycin and cytosine arabinoside

1983 • 16 citations

Effect of Cytarabine on the NMR Structure of a Model Okazaki Fragment from the SV40 Genome

1999 • 16 citations

Relationship between aberrant DNA replication and loss of cell viability in Chinese hamster ovary CHO-K1 cells.

1982 • 13 citations

A possible role for topoisomerase II in cell death and N-phosphonoacetyl-l-aspartate-resistance frequency and its enhancement by 1-β-d-arabinofuranosyl cytosine and 5-fluoro-2′-deoxyuridine

1997 • 5 citations