Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

DNA Topoisomerases

1981 • 977 citations

DNA Gyrase and the Supercoiling of DNA

1980 • 713 citations

DNA Modification and Cancer

1981 • 688 citations

Type II DNA topoisomerases: Enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break

1980 • 547 citations

Cleavage of DNA by mammalian DNA topoisomerase II.

1983 • 539 citations

Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino)methanesulfon-m-anisidide and adriamycin

1981 • 382 citations

A homogeneous type II DNA topoisomerase from HeLa cell nuclei.

1981 • 361 citations

Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster.

1983 • 284 citations

Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents

1977 • 258 citations

Qualitative and quantitative aspects of intercalator-induced DNA strand breaks

1979 • 244 citations

Protein-associated DNA breaks in cells treated with adriamycin or ellipticine

1978 • 234 citations

Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases

1981 • 231 citations

DNA Topoisomerases-Enzymes that Catalyse the Breaking and Rejoining of DNA

1983 • 216 citations

DNA double-strand breaks in mammalian cells after exposure to intercalating agents

1981 • 160 citations

The experimental antitumour properties of three congeners of the acridylmethanesulphonanilide (AMSA) series

1974 • 155 citations

Interaction of the antitumor drug 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines with nucleic acids.

1981 • 98 citations

Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide.

1982 • 97 citations

Protein-associated deoxyribonucleic acid strand breaks produced in mouse leukemia L1210 cells by ellipticine and 2-methyl-9-hydroxyellipticinium

1982 • 90 citations

The binding of gyrase to DNA: analysis by retention by nitrocellulose filters

1982 • 80 citations

Cell-Cycle-Specific Chromosome Damage Following Treatment of Cultured Chinese Hamster Cells With 4′-[(9-Acridinyl-amino] methanesulphon-m-anisidide-HCl2

1978 • 56 citations

Induction of limited DNA damage by the antitumor agent Cain's acridine.

1978 • 46 citations

Ellipticine and derivatives induce breakage of L1210 cells DNA in vitro

1979 • 41 citations

On the mechanism of action of 4′-[(9-acridinyl)-amino] methanesulphon-m-anisidide

1980 • 26 citations

Blocked 5′-termini in the fragments of chromosomal DNA produced in cells exposed to the antitumour drug 4′-[(9-acridinyl)-amino]methanesulphon-m-anisidide (mAMSA)

1983 • 20 citations

Lethal activity and kinetic response of cultured human cells to 4'-(9-acridinylamino)methanesulfon-m-anisidine.

1982 • 14 citations