The Werner Syndrome Gene Product Co-purifies with the DNA Replication Complex and Interacts with PCNA and Topoisomerase I

Positional Cloning of the Werner's Syndrome Gene

1996 • 1,696 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

1997 • 1,477 citations

A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

1966 • 831 citations

The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.

1994 • 686 citations

Sgs1: A eukaryotic homolog of E. coil RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

1995 • 402 citations

SGS1, a Homologue of the Bloom's and Werner's Syndrome Genes, Is Required for Maintenance of Genome Stability in Saccharomyces cerevisiae

1996 • 380 citations

Human Werner Syndrome DNA Helicase Unwinds Tetrahelical Structures of the Fragile X Syndrome Repeat Sequence d(CGG)

1999 • 362 citations

Functional and Physical Interaction between WRN Helicase and Human Replication Protein A

1999 • 302 citations

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

1998 • 295 citations

A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

1995 • 276 citations

Escherichia coli RecQ protein is a DNA helicase.

1990 • 263 citations

Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen

1998 • 251 citations

Proliferating cell nuclear antigen: More than a clamp for DNA polymerases

1997 • 248 citations

RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli

1997 • 246 citations

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

1992 • 207 citations

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

1997 • 207 citations

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

1996 • 201 citations

p53-Mediated apoptosis is attenuated in Werner syndrome cells

1999 • 175 citations

The gene responsible for Werner syndrome may be a cell division "counting" gene.

1993 • 157 citations

Wiskott–Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases

1996 • 154 citations

Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication

1998 • 152 citations

Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.

1997 • 146 citations

Replication focus-forming activity 1 and the Werner syndrome gene product

1998 • 139 citations

The Expression of Poly(ADP-ribose) Polymerase during Differentiation-Linked DNA Replication Reveals That It Is a Component of the Multiprotein DNA Replication Complex

1996 • 136 citations

Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts

1981 • 109 citations

Differential Effects of Cytotoxic Drugs on Mortal and Immortalized B-Lymphoblastoid Cell Lines from Normal and Werner's Syndrome Patients.

1998 • 71 citations

A 17S multiprotein form of murine cell DNA polymerase mediates polyomavirus DNA replication in vitro

1994 • 50 citations

Werner's syndrome: proliferation in vitro of clones of cells bearing chromosome translocations.

1984 • 45 citations

Effects of topoisomerase II inhibition in lymphoblasts from patients with progeroid and “chromosome instability” syndromes

1996 • 36 citations

Werner’s Syndrome Associated with Malignancies:Five Case Reports with a Survey of Case Histories in Japan

1988 • 34 citations

Cloning of a Mouse Homologue of the Human Werner Syndrome Gene and Assignment to 8A4 by Fluorescencein SituHybridization

1997 • 29 citations

A novel assay for examining the molecular reactions at the eukaryotic replication fork: activities of replication protein A required during elongation

1999 • 21 citations

Stimulation of mouse DNA primase-catalyzed oligoribonucleotide synthesis by mouse DNA helicase B

1995 • 16 citations