Aurora Kinases as Anticancer Drug Targets

Erlotinib in Previously Treated Non–Small-Cell Lung Cancer

2005 • 5,383 citations

Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma

2007 • 4,669 citations

Patterns of somatic mutation in human cancer genomes

2007 • 2,975 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2003 • 1,175 citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2004 • 944 citations

Aurora-A — A guardian of poles

2005 • 670 citations

Aurora-kinase inhibitors as anticancer agents

2004 • 658 citations

Roles of Aurora Kinases in Mitosis and Tumorigenesis

2007 • 583 citations

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

1997 • 483 citations

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

2007 • 410 citations

MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation

2006 • 369 citations

AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

2007 • 342 citations

Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.

2003 • 329 citations

Cell cycle kinases in cancer

2007 • 329 citations

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

2003 • 318 citations

Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast.

1999 • 306 citations

Amplification/Overexpression of a Mitotic Kinase Gene in Human Bladder Cancer

2002 • 303 citations

Overexpression and Amplification of Aurora-A in Hepatocellular Carcinoma

2004 • 302 citations

Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability.

2002 • 288 citations

The chromosomal passenger complex: guiding Aurora-B through mitosis

2006 • 281 citations

Validating Aurora B as an anti-cancer drug target

2006 • 279 citations

Aurora kinases, aneuploidy and cancer, a coincidence or a real link?

2005 • 268 citations

Aurora‐C kinase is a novel chromosomal passenger protein that can complement Aurora‐B kinase function in mitotic cells

2004 • 262 citations

Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

1999 • 249 citations

Association of centrosomal kinaseSTK15/BTAK mRNA expression with chromosomal instability in human breast cancers

2001 • 231 citations

RNA Interference Targeting Aurora Kinase A Suppresses Tumor Growth and Enhances the Taxane Chemosensitivity in Human Pancreatic Cancer Cells

2005 • 217 citations

A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy

2006 • 216 citations

Current Status and Future Prospects for Satraplatin, an Oral Platinum Analogue

2008 • 208 citations

Aurora B Overexpression Associates with the Thyroid Carcinoma Undifferentiated Phenotype and Is Required for Thyroid Carcinoma Cell Proliferation

2005 • 202 citations

Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle

2004 • 202 citations

Aurora Kinase A Messenger RNA Overexpression Is Correlated with Tumor Progression and Shortened Survival in Head and Neck Squamous Cell Carcinoma

2006 • 190 citations

Targeting Aurora Kinases for the Treatment of Prostate Cancer

2006 • 182 citations

The Aurora Kinase Inhibitor VX-680 Induces Endoreduplication and Apoptosis Preferentially in Cells with Compromised p53-Dependent Postmitotic Checkpoint Function

2006 • 178 citations

Aurora kinases: shining lights on the therapeutic horizon?

2005 • 177 citations

Aurora kinases in spindle assembly and chromosome segregation

2004 • 167 citations

PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity

2006 • 160 citations

Overexpression of Aurora-A Contributes to Malignant Development of Human Esophageal Squamous Cell Carcinoma

2004 • 159 citations

Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability

2005 • 150 citations

Aurora‐A induces cell survival and chemoresistance by activation of Akt through a p53‐dependent manner in ovarian cancer cells

2006 • 146 citations

Overexpression of the Centrosomal Protein Aurora-A Kinase is Associated with Poor Prognosis in Epithelial Ovarian Cancer Patients

2007 • 146 citations

Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas.

2003 • 146 citations

Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis

2006 • 145 citations

Aurora- A/STK15 T + 91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types

2005 • 141 citations

Microarray-Based Screening for Molecular Markers in Medulloblastoma Revealed STK15 as Independent Predictor for Survival

2004 • 140 citations

Aurora B expression directly correlates with prostate cancer malignancy and influence prostate cell proliferation

2005 • 139 citations

Frequent overexpression of aurora B kinase, a novel drug target, in non–small cell lung carcinoma patients

2006 • 126 citations

CDC25B Phosphorylation by Aurora A Occurs at the G2/M Transition and is Inhibited by DNA Damage

2005 • 123 citations

Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase

2005 • 116 citations

“Oncogenic Shock”: Explaining Oncogene Addiction through Differential Signal Attenuation

2006 • 114 citations

Vinflunine: A New Microtubule Inhibitor Agent

2008 • 113 citations

Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer

2007 • 109 citations

Aurora B expression correlates with aggressive behaviour in glioblastoma multiforme

2007 • 106 citations

Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis

2004 • 103 citations

High Expression of Aurora-B/Aurora and Ipl1-Like Midbody-Associated Protein (AIM-1) in Astrocytomas

2004 • 95 citations

Newer Cytotoxic Agents: Attacking Cancer Broadly

2008 • 95 citations

Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152

2007 • 84 citations

Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States)

2006 • 82 citations

High copy amplification of the aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers

2007 • 81 citations

Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion

2004 • 75 citations

STK15/Aurora‐A expression in primary breast tumors is correlated with nuclear grade but not with prognosis

2003 • 74 citations

Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells

2004 • 71 citations

Predictive Value of Aurora-A/STK15 Expression for Late Stage Epithelial Ovarian Cancer Patients Treated by Adjuvant Chemotherapy

2007 • 68 citations

Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast.

2003 • 68 citations

Two Functional Coding Single Nucleotide Polymorphisms in STK15 (Aurora-A) Coordinately Increase Esophageal Cancer Risk

2005 • 68 citations

Breast cancer risk associated with genotypic polymorphism of the mitosis‐regulating gene Aurora‐A/STK15/BTAK

2005 • 67 citations

Aurora kinase inhibition downregulates NF-κB and sensitises tumour cells to chemotherapeutic agents

2006 • 66 citations

The Epothilones: Translating from the Laboratory to the Clinic

2008 • 63 citations

Aurora kinases A and B and familial breast cancer risk

2006 • 62 citations

The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas

2003 • 59 citations

DNA methylation promotes Aurora-B-driven phosphorylation of histone H3 in chromosomal subdomains

2006 • 57 citations

Overexpression and amplification of STK15 in human gliomas

2004 • 57 citations

Amplification and overexpression of Aurora-A in esophageal squamous cell carcinoma

2007 • 56 citations

The Suppression of Aurora-A/STK15/BTAK Expression Enhances Chemosensitivity to Docetaxel in Human Esophageal Squamous Cell Carcinoma

2007 • 53 citations

Phase I and pharmacological study of the novel aurora kinase inhibitor AZD1152

2006 • 51 citations

A phase I clinical and pharmacokinetic (PK) trial of the aurora kinase (AK) inhibitor MK-0457 in cancer patients

2006 • 48 citations

Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells

2006 • 47 citations

Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians

2006 • 47 citations

Aurora-A/STK-15 is a predictive factor for recurrent behaviour in non-invasive bladder carcinoma: a study of 128 cases of non-invasive neoplasms

2007 • 42 citations

Aurora A and B Overexpression and Centrosome Amplification in Early Estrogen-Induced Tumor Foci in the Syrian Hamster Kidney: Implications for Chromosomal Instability, Aneuploidy, and Neoplasia

2007 • 42 citations

Functional polymorphism 57Val>Ile of aurora kinase A associated with increased risk of gastric cancer progression

2006 • 40 citations

Association between Aurora-A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population

2007 • 36 citations

Significance of Aurora-A expression in renal cell carcinoma

2007 • 35 citations

Expression of serine threonine kinase 15 is associated with poor differentiation in lung squamous cell carcinoma and adenocarcinoma

2006 • 34 citations

Preferential amplification ofAURKA 91A (Ile31) in familial colorectal cancers

2005 • 34 citations

Aurora-A amplification associated with BRCA2 mutation in breast tumours

2006 • 33 citations

Breast cancer risk associated with AURKA 91T→A polymorphism in relation to BRCA mutations

2006 • 31 citations

Phase I clinical trial of MLN8054, a selective inhibitor of Aurora A kinase

2007 • 13 citations

Preclinical pharmacodynamic studies of Aurora A inhibition by MLN8054

2006 • 9 citations

27 ORAL Phase I dose escalation study of the aurora kinase inhibitor PHA-739358 administered as a 6-hour infusion on days 1, 8 and 15 every 4 weeks in patients with advanced/metastatic solid tumors

2006 • 7 citations

[Mutation of p53 and overexpression of STK15 in laryngeal squamous-cell carcinoma].

2005 • 5 citations

[Deletion of p15 and p16 genes and overexpression of STK15 gene in human laryngeal squamous cell carcinoma].

2003 • 5 citations