RNA Interference Targeting Aurora Kinase A Suppresses Tumor Growth and Enhances the Taxane Chemosensitivity in Human Pancreatic Cancer Cells

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Stable suppression of tumorigenicity by virus-mediated RNA interference

2002 • 1,147 citations

Pancreatic cancer biology and genetics

2002 • 1,105 citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2004 • 944 citations

ZD1839, a Selective Oral Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitor, Is Well Tolerated and Active in Patients With Solid, Malignant Tumors: Results of a Phase I Trial

2002 • 764 citations

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

2003 • 615 citations

Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

2003 • 610 citations

Human TPX2 is required for targeting Aurora-A kinase to the spindle

2002 • 563 citations

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

1997 • 483 citations

Suppression of BRAF(V599E) in human melanoma abrogates transformation.

2003 • 412 citations

Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs

1998 • 380 citations

A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics

2004 • 377 citations

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

2003 • 361 citations

Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast.

1999 • 306 citations

Amplification/Overexpression of a Mitotic Kinase Gene in Human Bladder Cancer

2002 • 303 citations

Overexpression and Amplification of Aurora-A in Hepatocellular Carcinoma

2004 • 302 citations

Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer.

2003 • 300 citations

High-resolution characterization of the pancreatic adenocarcinoma genome

2004 • 279 citations

Focus on pancreas cancer

2002 • 215 citations

Aurora A, Meiosis and Mitosis

2004 • 153 citations

Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma

1997 • 125 citations

A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma

2001 • 92 citations

The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer

2004 • 77 citations

Paclitaxel and concurrent radiation for locally advanced pancreatic cancer

2001 • 67 citations

The Human PMS2L Proteins Do Not Interact with hMLHl, a Major DNA Mismatch Repair Protein

1999 • 51 citations

Establishment of six human pancreatic cancer cell lines and their sensitivities to anti-tumor drugs.

1986 • 47 citations

Phase II Study of Docetaxel in Patients with Pancreatic Cancer Previously Untreated with Cytotoxic Chemotherapy

2002 • 41 citations

Molecular Pathology of Pancreatic Cancer

2004 • 40 citations

[Meiosis and mitosis].

1968 • 24 citations