PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2003 • 1,175 citations

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

2003 • 1,144 citations

The cellular geography of Aurora kinases

2003 • 1,118 citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2004 • 944 citations

Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

2000 • 847 citations

Aurora-A — A guardian of poles

2005 • 670 citations

Aurora-kinase inhibitors as anticancer agents

2004 • 658 citations

Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases

2002 • 636 citations

Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis

2001 • 616 citations

Structural Basis of Aurora-A Activation by TPX2 at the Mitotic Spindle

2003 • 591 citations

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

2003 • 570 citations

Predictive Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Kinetics in Xenograft Models after Administration of Anticancer Agents

2004 • 461 citations

Borealin

2004 • 432 citations

The Aurora kinases: role in cell transformation and tumorigenesis.

2003 • 387 citations

Aurora kinases link chromosome segregation and cell division to cancer susceptibility

2003 • 341 citations

Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.

2003 • 329 citations

Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215

2004 • 307 citations

Overexpression and Amplification of Aurora-A in Hepatocellular Carcinoma

2004 • 302 citations

Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer.

2003 • 300 citations

Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit

2002 • 295 citations

Mitotic mechanics: the auroras come into view

2003 • 269 citations

Aurora‐C kinase is a novel chromosomal passenger protein that can complement Aurora‐B kinase function in mitotic cells

2004 • 262 citations

Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

1999 • 249 citations

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

2001 • 211 citations

Chfr is required for tumor suppression and Aurora A regulation

2005 • 194 citations

Mitotic Kinase Expression and Colorectal Cancer Progression

1999 • 177 citations

Aurora kinases in spindle assembly and chromosome segregation

2004 • 167 citations

APC/Fizzy‐Related targets Aurora‐A kinase for proteolysis

2002 • 162 citations

Overexpression of Aurora-A Contributes to Malignant Development of Human Esophageal Squamous Cell Carcinoma

2004 • 159 citations

3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 1. Lead Finding

2004 • 153 citations

Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway

2000 • 146 citations

Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition

2005 • 141 citations

Aurora Kinase Inhibitor ZM447439 Blocks Chromosome-induced Spindle Assembly, the Completion of Chromosome Condensation, and the Establishment of the Spindle Integrity Checkpoint inXenopusEgg Extracts

2004 • 126 citations

Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase

2005 • 116 citations

Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function

2002 • 111 citations

Phosphorylation of Histone H3 at Serine 10 Is Indispensable for Neoplastic Cell Transformation

2005 • 104 citations

The D‐Box‐activating domain (DAD) is a new proteolysis signal that stimulates the silent D‐Box sequence of Aurora‐A

2002 • 89 citations

Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells

2004 • 71 citations

Cdc20 associates with the kinase aurora2/Aik

1999 • 68 citations

The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus

2005 • 54 citations

Identification of Aurora Kinases as RasGAP Src Homology 3 Domain-binding Proteins

2002 • 42 citations

The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1

2002 • 39 citations

Phosphorylation of histone and histone-like proteins by aurora kinases during mitosis.

2003 • 35 citations

Divide and Conquer: New Generation of Drugs Targets Mitosis

2005 • 21 citations