Programmed Death 1 Ligand (PD-L) 1 and PD-L2 Limit Autoimmune Kidney Disease: Distinct Roles

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

2007 • 1,416 citations

Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity

2004 • 1,213 citations

Tissue expression of PD-L1 mediates peripheral T cell tolerance

2006 • 1,145 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

The PD-1–PD-L pathway in immunological tolerance

2006 • 681 citations

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

2004 • 609 citations

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

2003 • 594 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis

2003 • 436 citations

Establishment of NOD-Pdcd1^-/-mice as an efficient animal model of type I diabetes

2005 • 409 citations

Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis

1999 • 265 citations

Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial Cells

2002 • 256 citations

MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells

1990 • 246 citations

Identification and Functional Characterization of Dendritic Cells in the Healthy Murine Kidney and in Experimental Glomerulonephritis

2004 • 241 citations

Programmed Death-1 Targeting Can Promote Allograft Survival

2002 • 236 citations

PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis

2006 • 176 citations

Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice

1997 • 168 citations

Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis

1999 • 167 citations

The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells

2004 • 160 citations

IL-12 Deficiency in MRL-FaslprMice Delays Nephritis and Intrarenal IFN-γ Expression, and Diminishes Systemic Pathology

2003 • 149 citations

Lectin-peroxidase conjugate reactivity in normal human kidney.

1982 • 143 citations

IFN-γ Mediates Crescent Formation and Cell-Mediated Immune Injury in Murine Glomerulonephritis

1999 • 134 citations

Cutting Edge: Programed Death (PD) Ligand-1/PD-1 Interaction Is Required for CD8+ T Cell Tolerance to Tissue Antigens

2006 • 131 citations

Differential Role of Programmed Death-Ligand 1 and Programmed Death-Ligand 2 in Regulating the Susceptibility and Chronic Progression of Experimental Autoimmune Encephalomyelitis

2006 • 115 citations

Renal cell–expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis

2005 • 110 citations

Cross-linking the B7 Family Molecule B7-DC Directly Activates Immune Functions of Dendritic Cells

2002 • 104 citations

Suppressed T-cell activation by IFN- -induced expression of PD-L1 on renal tubular epithelial cells

2004 • 101 citations

A role for P selectin in complement-independent neutrophil-mediated glomerular injury

1994 • 98 citations

Antibody independent crescentic glomerulonephritis in μ chain deficient mice

1997 • 95 citations

Renal cell–expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis

2005 • 93 citations

Anti-CD8 Monoclonal Antibody Therapy Is Effective in the Prevention and Treatment of Experimental Autoimmune Glomerulonephritis

2002 • 91 citations

Negative Role of Colony-Stimulating Factor-1 in Macrophage, T Cell, and B Cell Mediated Autoimmune Disease in MRL-Fas lpr Mice

2004 • 90 citations

IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis

1999 • 87 citations

PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis

2005 • 82 citations

Costimulation by B7-1 and B7-2 Is Required for Autoimmune Disease in MRL-FaslprMice

2000 • 76 citations

Tubular Epithelial Cells: A Critical Cell Type in the Regulation of Renal Inflammatory Processes

1999 • 75 citations

Renal tubular dysgenesis: Delayed onset of oligohydramnios

1989 • 65 citations

Experimental autoimmune Goodpasture's disease: A pathogenetic role for both effector cells and antibody in injury

2005 • 63 citations

Glomerular lesions in nonobese diabetic mouse: before and after the onset of hyperglycemia.

1990 • 62 citations

PD-L1 partially protects renal tubular epithelial cells from the attack of CD8+cytotoxic T cells

2007 • 56 citations

The antigen presentation function of renal tubular epithelial cells.

1993 • 54 citations

Regulatory interactions of αβ and γλ T cells in glomerulonephritis

2000 • 45 citations

TNF-alpha enhances colony-stimulating factor-1-induced macrophage accumulation in autoimmune renal disease.

1996 • 41 citations

Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA

2005 • 34 citations

B7-DC/PD-L2 Cross-Linking Induces NF-κB-Dependent Protection of Dendritic Cells from Cell Death

2007 • 27 citations

Nephritogenic cytokines and disease in MRL-Fas kidneys are dependent on multiple T-cell subsets

2001 • 21 citations