Cytokines and T-cell homeostasis

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

2005 • 1,167 citations

Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

2005 • 919 citations

Interleukin-10 determines viral clearance or persistence in vivo

2006 • 888 citations

Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

2006 • 843 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

2006 • 770 citations

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

2006 • 769 citations

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function

2005 • 684 citations

Signals required for programming effector and memory development by CD8⁺ T cells

2006 • 574 citations

Resolution of a chronic viral infection after interleukin-10 receptor blockade

2006 • 538 citations

T Cell Memory

2002 • 529 citations

Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

2004 • 472 citations

HIV-1 Viremia Prevents the Establishment of Interleukin 2–producing HIV-specific Memory CD4+ T Cells Endowed with Proliferative Capacity

2003 • 443 citations

Converting IL-15 to a superagonist by binding to soluble IL-15Rα

2006 • 388 citations

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

2003 • 384 citations

Combined IL-15/IL-15Rα Immunotherapy Maximizes IL-15 Activity In Vivo

2006 • 349 citations

Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation

2006 • 323 citations

Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection

2005 • 314 citations

Functional signatures of protective antiviral T‐cell immunity in human virus infections

2006 • 276 citations

Homeostasis of memory T cells

2006 • 275 citations

Bone Marrow Is a Preferred Site for Homeostatic Proliferation of Memory CD8 T Cells

2005 • 273 citations

Direct Stimulation of T Cells by Type I IFN Enhances the CD8+ T Cell Response during Cross-Priming

2006 • 269 citations

Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool

2005 • 224 citations

Cutting Edge: The Direct Action of Type I IFN on CD4 T Cells Is Critical for Sustaining Clonal Expansion in Response to a Viral but Not a Bacterial Infection

2006 • 206 citations

Epigenetic Remodeling of theIL-2andIFN-γ Loci in Memory CD8 T Cells Is Influenced by CD4 T Cells

2006 • 206 citations

Innate Inflammatory Signals Induced by Various Pathogens Differentially Dictate the IFN-I Dependence of CD8 T Cells for Clonal Expansion and Memory Formation

2006 • 199 citations

IL-7 regulates basal homeostatic proliferation of antiviral CD4 ⁺ T cell memory

2004 • 197 citations

IL-15-Dependent Induction of 4-1BB Promotes Antigen-Independent CD8 Memory T Cell Survival

2006 • 140 citations

Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease

2006 • 139 citations

IL-2 Regulates Perforin and Granzyme Gene Expression in CD8+ T Cells Independently of Its Effects on Survival and Proliferation

2005 • 138 citations

CD8 Cell Division Maintaining Cytotoxic Memory Occurs Predominantly in the Bone Marrow

2005 • 134 citations

T cell homeostasis: Keeping useful T cells alive and live T cells useful

2005 • 124 citations

IFN-Induced Attrition of CD8 T Cells in the Presence or Absence of Cognate Antigen during the Early Stages of Viral Infections

2006 • 117 citations

IL-15 Regulates CD8+ T Cell Contraction during Primary Infection

2006 • 112 citations

IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques

2004 • 105 citations

Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells

2005 • 105 citations

Cutting Edge: Bcl-3 Up-Regulation by Signal 3 Cytokine (IL-12) Prolongs Survival of Antigen-Activated CD8 T Cells

2005 • 98 citations

IL-10 Is Required for Optimal CD8 T Cell Memory followingListeria monocytogenesInfection

2006 • 96 citations

SOCS-1 regulates IL-15–driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential

2005 • 87 citations

Homeostasis and T cell regulation

2004 • 81 citations

Cutting Edge: IL-7-Independent Regulation of IL-7 Receptor α Expression and Memory CD8 T Cell Development

2006 • 75 citations

IL-2 In Vivo Activities and Antitumor Efficacy Enhanced by an Anti-IL-2 mAb

2006 • 66 citations

IL-12 Priming during In Vitro Antigenic Stimulation Changes Properties of CD8 T Cells and Increases Generation of Effector and Memory Cells

2004 • 66 citations

IL-2 Is Required for the Activation of Memory CD8+ T Cells via Antigen Cross-Presentation

2006 • 62 citations

A major histocompatibility complex class I–dependent subset of memory phenotype CD8+ cells

2006 • 58 citations

Augmented IL-7 Signaling during Viral Infection Drives Greater Expansion of Effector T Cells but Does Not Enhance Memory

2006 • 57 citations

Cutting Edge: Early IFN-γ Signaling Directly Enhances Primary Antiviral CD4+ T Cell Responses

2005 • 55 citations

IL-12-Programmed Long-Term CD8+ T Cell Responses Require STAT4

2006 • 50 citations

Priming in the Presence of IL-10 Results in Direct Enhancement of CD8+ T Cell Primary Responses and Inhibition of Secondary Responses

2005 • 49 citations

A Major Role for Memory CD4 T Cells in the Control of Lymphopenia-Induced Proliferation of Naive CD4 T Cells

2005 • 48 citations

Suppressor of Cytokine Signaling 1 Stringently Regulates Distinct Functions of IL-7 and IL-15 In Vivo during T Lymphocyte Development and Homeostasis

2006 • 47 citations

Not all CD4⁺ memory T cells are long lived

2006 • 42 citations

Enhanced TCR-induced Apoptosis in Interferon Regulatory Factor 4–deficient CD4+ Th Cells

2004 • 36 citations

CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4

2006 • 23 citations

Duration of CTL activation regulates IL‐2 production required for autonomous clonal expansion

2006 • 18 citations