IL-7 Administration to Humans Leads to Expansion of CD8+ and CD4+ Cells but a Relative Decrease of CD4+ T-Regulatory Cells

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

1998 • 1,826 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Defective IL7R expression in T-B+NK+ severe combined immunodeficiency

1998 • 805 citations

CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells

2005 • 741 citations

IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients

2005 • 602 citations

Interleukin-7: from bench to clinic

2002 • 496 citations

Increases in CD4 T Lymphocytes with Intermittent Courses of Interleukin-2 in Patients with Human Immunodeficiency Virus Infection — A Preliminary Study

1995 • 430 citations

A potential role for interleukin-7 in T-cell homeostasis

2001 • 415 citations

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

2005 • 378 citations

The main function of IL-2 is to promote the development of T regulatory cells

2003 • 323 citations

IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates

2002 • 244 citations

In vivo expansion of CD4+CD45RO-CD25+ T cells expressing foxP3 in IL-2-treated HIV-infected patients

2005 • 123 citations

Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function

2004 • 100 citations

Development of lymphocytes in interleukin 7‐transgenic mice

1991 • 90 citations

Administration of IL-7 to mice with cyclophosphamide-induced lymphopenia accelerates lymphocyte repopulation.

1991 • 88 citations

A dose effect of IL-7 on thymocyte development

2004 • 78 citations

Lymphoproliferative disorders in IL-7 transgenic mice: expansion of immature B cells which retain macrophage potential

1995 • 70 citations

Prospective immunological profiling in a case of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX)

2004 • 34 citations

Development of CD4 and CD8 single positive T cells in human thymus organ culture: IL-7 promotes human T cell production by supporting immature T cells

1996 • 19 citations

T-Cell Reconstitution by Molecular, Phenotypic, and Functional Analysis in the Thymus, Bone Marrow, Spleen, and Blood Following Split-Dose Polychemotherapy and Therapeutic Activity for Metastatic Breast Cancer in Mice

1993 • 13 citations