Elevated Expression Levels of Inhibitory Receptor Programmed Death 1 on Simian Immunodeficiency Virus-Specific CD8 T Cells during Chronic Infection but Not after Vaccination

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

1999 • 2,206 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Vigorous HIV-1-Specific CD4 ⁺ T Cell Responses Associated with Control of Viremia

1997 • 1,868 citations

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

2005 • 1,746 citations

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

2006 • 1,485 citations

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

1999 • 1,428 citations

HIV preferentially infects HIV-specific CD4+ T cells

2002 • 1,246 citations

Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

2002 • 1,180 citations

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine

2001 • 1,128 citations

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

2002 • 986 citations

Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination

2000 • 901 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

Memory CD8 T-Cell Differentiation during Viral Infection

2004 • 841 citations

The PD-1–PD-L pathway in immunological tolerance

2006 • 681 citations

Reservoirs for HIV-1: Mechanisms for Viral Persistence in the Presence of Antiviral Immune Responses and Antiretroviral Therapy

2000 • 528 citations

T cells and viral persistence: lessons from diverse infections

2005 • 407 citations

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

2006 • 396 citations

Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1–infected subjects with progressive disease: changes after antiretroviral therapy

2003 • 380 citations

Association between Virus-Specific Cytotoxic T-Lymphocyte and Helper Responses in Human Immunodeficiency Virus Type 1 Infection

1999 • 374 citations

Interleukin‐2 receptor common γ‐chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti‐apoptotic (bcl‐2, bcl‐x_L) but not pro‐apoptotic (bax, bcl‐x_S) gene expression

1996 • 367 citations

Programmed Death-1 (PD-1) is a Marker of Germinal Center-associated T Cells and Angioimmunoblastic T-Cell Lymphoma

2006 • 343 citations

Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag

2005 • 269 citations

Vaccine-Induced Cellular Immune Responses Reduce Plasma Viral Concentrations after Repeated Low-Dose Challenge with Pathogenic Simian Immunodeficiency Virus SIVmac239

2006 • 252 citations

T cell vaccines for microbial infections

2005 • 217 citations

Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4⁺T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2

2003 • 198 citations

Sensitive and Robust One-Tube Real-Time Reverse Transcriptase-Polymerase Chain Reaction to Quantify SIV RNA Load: Comparison of One- versus Two-Enzyme Systems

2000 • 171 citations

Effects of in Vivo Cd8+ T Cell Depletion on Virus Replication in Rhesus Macaques Immunized with a Live, Attenuated Simian Immunodeficiency Virus Vaccine

1999 • 159 citations

Containment of Simian Immunodeficiency Virus Infection in Vaccinated Macaques: Correlation with the Magnitude of Virus-Specific Pre- and Postchallenge CD4+ and CD8+ T Cell Responses

2002 • 159 citations

Critical Role for Env as well as Gag-Pol in Control of a Simian-Human Immunodeficiency Virus 89.6P Challenge by a DNA Prime/Recombinant Modified Vaccinia Virus Ankara Vaccine

2002 • 154 citations

Mucosal Priming of Simian Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Responses in Rhesus Macaques by theSalmonellaType III Secretion Antigen Delivery System

2003 • 105 citations

Novel Adeno-Associated Virus Vector Vaccine Restricts Replication of Simian Immunodeficiency Virus in Macaques

2004 • 86 citations

Turning on the off switch: Regulation of anti-viral T cell responses in the liver by the PD-1/PD-L1 pathway

2006 • 50 citations

TeGenero fiasco prompts regulatory rethink

2006 • 50 citations

Biodistribution and persistence of an MVA-vectored candidate HIV vaccine in SIV-infected rhesus macaques and SCID mice

2004 • 41 citations

Signature for Long-Term Vaccine-Mediated Control of a Simian and Human Immunodeficiency Virus 89.6P Challenge: Stable Low-Breadth and Low-Frequency T-Cell Response Capable of Coproducing Gamma Interferon and Interleukin-2

2005 • 30 citations

A Combination DNA and Attenuated Simian Immunodeficiency Virus Vaccine Strategy Provides Enhanced Protection from Simian/Human Immunodeficiency Virus-Induced Disease

2005 • 21 citations