Nitric Oxide Modulates Mitochondrial Respiration in Failing Human Heart

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Effect of Amlodipine on Morbidity and Mortality in Severe Chronic Heart Failure

1996 • 1,182 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Reversal of Chronic Ventricular Dilation in Patients With End-Stage Cardiomyopathy by Prolonged Mechanical Unloading

1995 • 431 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells.

1982 • 349 citations

Hypoxemia Is Associated With Mitochondrial DNA Damage and Gene Induction

1991 • 325 citations

Role of nitric oxide in the regulation of oxygen consumption in conscious dogs.

1994 • 320 citations

Reduced Nitric Oxide Production and Altered Myocardial Metabolism During the Decompensation of Pacing-Induced Heart Failure in the Conscious Dog

1998 • 310 citations

Reduced Gene Expression of Vascular Endothelial NO Synthase and Cyclooxygenase-1 in Heart Failure

1996 • 271 citations

Amlodipine Releases Nitric Oxide From Canine Coronary Microvessels

1998 • 268 citations

Nitric Oxide

1995 • 266 citations

Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency

1996 • 263 citations

Nitrite Inhibition of Clostridium botulinum : Electron Spin Resonance Detection of Iron-Nitric Oxide Complexes

1983 • 261 citations

Role of Endothelium-Derived Nitric Oxide in the Modulation of Canine Myocardial Mitochondrial Respiration In Vitro

1996 • 233 citations

Function and Production of Nitric Oxide in the Coronary Circulation of the Conscious Dog During Exercise

1996 • 190 citations

ACE Inhibitors Promote Nitric Oxide Accumulation to Modulate Myocardial Oxygen Consumption

1997 • 188 citations

Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy

1990 • 174 citations

Endogenous Endothelial Nitric Oxide Synthase–Derived Nitric Oxide Is a Physiological Regulator of Myocardial Oxygen Consumption

1999 • 173 citations

Regulation of Nitric Oxide Production in Human Coronary Microvessels and the Contribution of Local Kinin Formation

1996 • 156 citations

Mitochondrial abnormalities in myocardium of dogs with chronic heart failure

1992 • 142 citations

Canine hindlimb blood flow and O2 uptake after inhibition of EDRF/NO synthesis

1994 • 125 citations

Improvement of myocardial mitochondrial function after hemodynamic support with left ventricular assist devices in patients with heart failure

1998 • 121 citations

Role of Nitric Oxide in the Control of Renal Oxygen Consumption and the Regulation of Chemical Work in the Kidney

1998 • 118 citations

Beneficial actions of nitrates in cardiovascular disease

1996 • 116 citations

Effects of long-term therapy with ACE inhibitors, captopril, enalapril and trandolapril, on myocardial energy metabolism in rats with heart failure following myocardial infarction

1995 • 106 citations

Biochemical studies of energy production in the failing human heart.

1966 • 93 citations

Normal Oxidative Phosphorylation in Mitochondria from the Failing Heart

1967 • 80 citations

Regional differences in capillary density and myocyte size in the normal human heart

1982 • 73 citations

Some biochemical studies on subcellular systems isolated from fresh recipient human cardiac tissue obtained during transplantation

1971 • 72 citations

Combined Neutral Endopeptidase and Angiotensin-Converting Enzyme Inhibition in Heart Failure: Role of Natriuretic Peptides and Angiotensin II

1998 • 68 citations

Energy levels at systole vs. diastole in normal hamster hearts vs. myopathic hamster hearts.

1983 • 64 citations

Oxidative phosphorylation and calcium transport of mitochondria isolated from cardiomyopathic hamster hearts

1970 • 61 citations

A 94-kDa protein, identified as neutral endopeptidase-24.11, can inactivate atrial natriuretic peptide in the vascular endothelium.

1992 • 59 citations

Improvement of human myocardial mitochondria after dobutamine: a quantitative ultrastructural study.

1980 • 54 citations

Characterization of neutral endopeptidase in vascular cells, modulation of vasoactive peptide levels

1998 • 51 citations

Cardiomyopathy with mitochondrial DNA mutations

1991 • 46 citations

Angiotensin-Converting Enzyme Inhibitors Promote Nitric Oxide Production in Coronary Microvessels from Failing Explanted Human Hearts

1997 • 38 citations

Role of Nitric Oxide in the Control of Cardiac Oxygen Consumption in B ₂ -Kinin Receptor Knockout Mice

1999 • 34 citations

Neurohormonal Activation and Exercise Function in Patients With Severe Heart Failure and Patients With Left Ventricular Assist System

1995 • 28 citations

Neutral Endopeptidase and Angiotensin-Converting Enzyme Inhibitors Increase Nitric Oxide Production in Isolated Canine Coronary Microvessels by a Kinin-Dependent Mechanism

1998 • 23 citations

Oxidative phosphorylation and respiration by mitochondria from normal, hypertrophied and failing rat hearts

1977 • 20 citations

Myocardial respiratory chain enzyme activities in idiopathic dilated cardiomyopathy, and comparison with those in atherosclerotic coronary artery disease and valvular aortic stenosis

1993 • 20 citations

Alkyl nitrites. XV. The effect of nitrites and nitrates on the oxygen uptake of arterial tissue.

1951 • 14 citations

Increased circulating atrial natriuretic factor concentrations in patients with chronic heart failure after inhibition of neutral endopeptidase: effects on diastolic function

1992 • 14 citations

Effect of nitroglycerin on rat myocardium oxygen consumption, determined by the manometric Warburg procedure.

1991 • 1 citations