Cytokines and Insulin Induce Cationic Amino Acid Transporter (CAT) Expression in Cardiac Myocytes

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Current protocols in molecular biology

1988 • 2,473 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Regulation of biosynthesis of nitric oxide.

1994 • 1,698 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

1994 • 1,200 citations

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

1994 • 1,173 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Nitric oxide release accounts for insulin's vascular effects in humans.

1994 • 747 citations

Stimulation of insulin secretion by amino acids.

1966 • 707 citations

A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection

1989 • 692 citations

Blood and other body fluids

1961 • 681 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

1993 • 656 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay.

1989 • 580 citations

Transport of cationic amino acids by the mouse ecotropic retrovirus receptor

1991 • 552 citations

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.

1993 • 543 citations

BIOSYNTHESIS AND METABOLISM OF TETRAHYDROBIOPTERIN AND MOLYBDOPTERIN

1985 • 542 citations

Blood and Other Body Fluids

1961 • 528 citations

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output.

1992 • 493 citations

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

1991 • 458 citations

Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium.

1993 • 457 citations

The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine.

1990 • 456 citations

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

1992 • 444 citations

Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter

1991 • 439 citations

Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro.

1994 • 436 citations

Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides

1992 • 415 citations

Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells.

1991 • 403 citations

Nitric Oxide-dependent Parasympathetic Signaling Is Due to Activation of Constitutive Endothelial (Type III) Nitric Oxide Synthase in Cardiac Myocytes

1995 • 381 citations

Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha.

1991 • 369 citations

Regulatory and molecular aspects of mammalian amino acid transport

1994 • 368 citations

Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.

1990 • 356 citations

Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 Kinase

1993 • 277 citations

Biosynthesis of endothelium-derived relaxing factor: A cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase

1989 • 271 citations

Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.

1993 • 266 citations

The cluster-tray method for rapid measurement of solute fluxes in adherent cultured cells

1981 • 263 citations

Regulation of Enzymes of Urea and Arginine Synthesis

1992 • 252 citations

<scp>l</scp>-arginine transport is increased in macrophages generating nitric oxide

1992 • 235 citations

Cloning of a rat kidney cDNA that stimulates dibasic and neutral amino acid transport and has sequence similarity to glucosidases.

1992 • 222 citations

Macrophages can convert citrulline into arginine

1992 • 217 citations

Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production.

1994 • 216 citations

Regulation of Protein Synthesis by Insulin

1994 • 198 citations

Recent Advances in Mammalian Amino Acid Transport

1993 • 194 citations

Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts.

1982 • 185 citations

Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver.

1993 • 185 citations

Regulation of Cytokine-inducible Nitric Oxide Synthase in Cardiac Myocytes and Microvascular Endothelial Cells

1996 • 163 citations

Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes.

1992 • 150 citations

Argininosuccinate synthetase mRNA and activity are induced by immunostimulants in vascular smooth muscle. Role in the regeneration or arginine for nitric oxide synthesis

1994 • 146 citations

Characterization of the third member of the MCAT family of cationic amino acid transporters. Identification of a domain that determines the transport properties of the MCAT proteins.

1993 • 145 citations

Cationic amino acid transport into cultured animal cells. II. Transport system barely perceptible in ordinary hepatocytes, but active in hepatoma cell lines.

1982 • 136 citations

Shortening velocity and ATPase activity of rat skeletal muscle fibers: effects of endurance exercise training

1994 • 134 citations

Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: Relationship to endogenous glucose production and peripheral tissue glucose uptake

1994 • 131 citations

The 4F2 antigen heavy chain induces uptake of neutral and dibasic amino acids in Xenopus oocytes.

1992 • 120 citations

Preproenkephalin mRNA expression in developing rat heart and in cultured ventricular cardiac muscle cells

1989 • 115 citations

GTP Cyclohydrolase I mRNA Is Induced by LPS in Vascular Smooth Muscle: Characterization, Sequence and Relationship to Nitric Oxide Synthase

1993 • 102 citations

Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydrobiopterin biosynthetic pathway.

1991 • 97 citations

Voltage dependence of facilitated arginine flux mediated by the system y+ basic amino acid transporter

1993 • 96 citations

Contractile Responsiveness of Ventricular Myocytes to Isoproterenol Is Regulated by Induction of Nitric Oxide Synthase Activityin Cardiac Microvascular EndothelialCells in Heterotypic Primary Culture

1995 • 90 citations

Dependence of endotoxin‐induced vascular hyporeactivity on extracellular <scp>l</scp>‐arginine

1993 • 87 citations

Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor.

1990 • 85 citations

Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family.

1994 • 78 citations

Hormonal regulation of the gene for the type C ecotropic retrovirus receptor in rat liver cells

1994 • 68 citations

<scp>l</scp>‐Arginine depletion by arginase reduces nitric oxide production in endotoxic shock: an electron paramagnetic resonance study

1995 • 56 citations

Characterization of amino acid transport in human endothelial cells

1993 • 50 citations

Transcriptional regulation in cardiac muscle. Coordinate expression of Id with a neonatal phenotype during development and following a hypertrophic stimulus in adult rat ventricular myocytes in vitro.

1992 • 41 citations

Cloning and expression in Escherichia coli of cDNA for arginase of rat liver

1986 • 29 citations

Growth Factor Regulation of Interleukin-1β-Induced Nitric Oxide Synthase and GTP: Cyclohydrolase Expression in Cultured Smooth Muscle Cells

1993 • 28 citations

Characterization of system L and system y⁺ amino acid transport activity in cultured vascular smooth muscle cells

1993 • 27 citations

Nutritional and hormonal regulation of mRNA abundance for arginine biosynthetic enzymes in kidney

1989 • 27 citations

Molecular cloning of cDNA for rat argininosuccinate lyase and its expression in rat hepatoma cell lines.

1986 • 26 citations

Physiological hyperinsulinemia inhibits myocardial protein degradation in vivo in the canine heart.

1992 • 25 citations

Effects of Pancreatic Hormones and Glucocorticosteroids on Argininosuccinate Synthetase and Argininosuccinase Activities of Rat Liver during the Perinatal Period:In Vivoandin VitroStudies^*

1986 • 16 citations